Characterizing the risk interplay between alcohol intake and body mass index on cirrhosis morbidity

It is thought that alcohol intake and body mass index (BMI) interact supra‐additively to modulate the risk of cirrhosis, but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI on the incidence of cirrhosis morbidity for participants of the United Kingdom Biobank (UKB) study.

[1]  Mary E. Haas,et al.  Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study. , 2020, Gastroenterology.

[2]  D. Böhning,et al.  The combined effect of alcohol and body mass index on risk of chronic liver disease: A systematic review and meta‐analysis of cohort studies , 2020, Liver international : official journal of the International Association for the Study of the Liver.

[3]  H. Innes,et al.  Late diagnosis of chronic liver disease in a community cohort (UK biobank): determinants and impact on subsequent survival. , 2020, Public health.

[4]  T. H. Nguyen,et al.  The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2020, The lancet. Gastroenterology & hepatology.

[5]  M. Färkkilä,et al.  Interaction between alcohol use and metabolic risk factors for liver disease: a critical review of epidemiological studies. , 2019, Alcoholism, clinical and experimental research.

[6]  S. Sharp,et al.  Impact of follow-up time and analytical approaches to account for reverse causality on the association between physical activity and health outcomes in UK Biobank , 2019, International journal of epidemiology.

[7]  J. Rehm,et al.  Immediate impact of minimum unit pricing on alcohol purchases in Scotland: controlled interrupted time series analysis for 2015-18 , 2019, BMJ.

[8]  J. Lazarus,et al.  Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies. , 2018, Journal of hepatology.

[9]  A. Jula,et al.  Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population , 2018, Hepatology.

[10]  Q. Anstee,et al.  The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease. , 2018, Journal of hepatology.

[11]  C. Sudlow,et al.  Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population , 2017, American journal of epidemiology.

[12]  K. Jager,et al.  Relative risk versus absolute risk: one cannot be interpreted without the other: Clinical Epidemiology in Nephrology , 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[13]  Phil Clayton,et al.  STCOMLIST: Stata module to list cumulative function in presence of competing risks , 2017 .

[14]  Laurent Castera,et al.  Screening for liver fibrosis in the general population: a call for action. , 2016, The lancet. Gastroenterology & hepatology.

[15]  V. Beral,et al.  Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents , 2016, The Lancet.

[16]  A. Walker,et al.  Causes of Death in People with Liver Cirrhosis in England Compared with the General Population: A Population-Based Cohort Study , 2015, The American Journal of Gastroenterology.

[17]  Y. Ben-Shlomo,et al.  Life course trajectories of alcohol consumption in the United Kingdom using longitudinal data from nine cohort studies , 2015, BMC Medicine.

[18]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[19]  M. Bellis,et al.  Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis , 2014, The Lancet.

[20]  Chien-Jen Chen,et al.  Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. , 2013, American journal of epidemiology.

[21]  E. Coviello STCOMPET: Stata module to generate cumulative incidence in presence of competing events , 2012 .

[22]  T. Spector,et al.  Longitudinal study of variation in body mass index in middle-aged UK females , 2012, AGE.

[23]  Chien-Jen Chen,et al.  Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. , 2010, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[24]  E. Barrett-Connor,et al.  Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study , 2009, Alimentary pharmacology & therapeutics.

[25]  George Davey Smith,et al.  Supplementary Table S1 , 2008 .