HeartBioPortal: an internet-of-omics for human cardiovascular disease data

Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17M deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, the state-of-the-art in computational infrastructure to study datasets associated with CVD has lagged far behind public resources widely available in the oncology field, where improved data science and visualization methods have led to the development of large-scale cancer genomics resources like MSKCC9s cBioPortal or NCI9s Genomic Data Commons (GDC) Portal. Developing a similar user-friendly computational platform could significantly lower the barriers between complex CVD data and researchers who want rapid, intuitive, and high-quality visual access to molecular profiles and clinical attributes from existing CVD projects. Here we present HeartBioPortal: a publicly available web application that provides intuitive visualization, analysis, and downloads of large-scale CVD data currently focused on gene expression, genetic association, and ancestry information. By democratizing access to anonymized CVD data, HeartBioPortal9s aim is to integrate relevant omics and clinical information across the biological dataverse to support CVD clinicians and researchers.