TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice

[1]  M. Staufenbiel,et al.  Innate immune memory in the brain shapes neurological disease hallmarks , 2018, Nature.

[2]  L. Leocani,et al.  AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[3]  R. Weinberg,et al.  TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching , 2017, bioRxiv.

[4]  R. Morita,et al.  MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1 , 2017, Nature Medicine.

[5]  S. Gupton,et al.  Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches , 2016, Developmental neurobiology.

[6]  S. Goldman,et al.  Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. , 2016, Cell stem cell.

[7]  S. Goldman,et al.  3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice , 2016, Nature Medicine.

[8]  Á. Chamorro,et al.  Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation , 2016, The Lancet Neurology.

[9]  Reid H. J. Olsen,et al.  Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory , 2016, The Journal of Neuroscience.

[10]  S. Gupton,et al.  Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis. , 2016, Journal of visualized experiments : JoVE.

[11]  Sripriya Ravindra Kumar,et al.  Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain , 2015, Nature Biotechnology.

[12]  Huiqing Liu,et al.  NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species , 2015, International journal of biological sciences.

[13]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[14]  T. Maniatis,et al.  An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex , 2014, The Journal of Neuroscience.

[15]  A. García-Sastre,et al.  Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9 , 2014, Nature Communications.

[16]  S. Gupton,et al.  A novel Netrin-1–sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching , 2014, The Journal of cell biology.

[17]  Lexiao Li,et al.  Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke , 2014, PloS one.

[18]  M. Schwartz,et al.  The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus , 2014, The EMBO journal.

[19]  J. Griffin,et al.  Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats , 2013, Stroke.

[20]  Wei Zhou,et al.  Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke , 2013, The Journal of Neuroscience.

[21]  D. Lowy,et al.  Isolation of Mouse Embryo Fibroblasts. , 2013, Bio-protocol.

[22]  Wei Shi,et al.  featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..

[23]  D. Cai,et al.  Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH , 2013, Nature.

[24]  Bruce A. Yankner,et al.  Inflammation links ageing to the brain , 2013, Nature.

[25]  S. Goldman,et al.  An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR1-Akt Pathway , 2013, The Journal of Neuroscience.

[26]  T. Dandekar,et al.  Identification of New Therapeutic Targets by Genome-Wide Analysis of Gene Expression in the Ipsilateral Cortex of Aged Rats after Stroke , 2012, PloS one.

[27]  P. Tak,et al.  The resolution of inflammation , 2012, Nature Reviews Immunology.

[28]  M. Chopp,et al.  An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents , 2012, Stroke.

[29]  Á. Chamorro,et al.  The immunology of acute stroke , 2012, Nature Reviews Neurology.

[30]  R. Morita,et al.  Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain , 2012, Nature Medicine.

[31]  Ann M. Stowe,et al.  CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke , 2012, Journal of Neuroinflammation.

[32]  E. Ringelstein,et al.  Monocyte Chemoattractant Protein-1-Deficiency Impairs the Expression of IL-6, IL-1β and G-CSF after Transient Focal Ischemia in Mice , 2011, PloS one.

[33]  P. Fagenholz,et al.  Hypoxia and inflammation. , 2011, The New England journal of medicine.

[34]  C. Iadecola,et al.  The immunology of stroke: from mechanisms to translation , 2011, Nature Medicine.

[35]  Z. Kokaia,et al.  Perturbed cellular response to brain injury during aging , 2011, Ageing Research Reviews.

[36]  D. Geschwind,et al.  Prospective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting , 2010, The Journal of Neuroscience.

[37]  J. Liao,et al.  NF‐κB and innate immunity in ischemic stroke , 2010, Annals of the New York Academy of Sciences.

[38]  Cori Bargmann,et al.  The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. , 2010, Developmental cell.

[39]  M. Farrer,et al.  Missing pieces in the Parkinson's disease puzzle , 2010, Nature Medicine.

[40]  Guohong Li,et al.  Inflammatory mechanisms in ischemic stroke: role of inflammatory cells , 2010, Journal of leukocyte biology.

[41]  A. Kakita,et al.  TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies , 2010, Neurobiology of Disease.

[42]  M. Tansey,et al.  Neuroinflammation in Parkinson’s Disease , 2009, Journal of Neuroimmune Pharmacology.

[43]  E. Hirsch,et al.  Neuroinflammation in Parkinson's disease: a target for neuroprotection? , 2009, The Lancet Neurology.

[44]  L. McCullough,et al.  Changes in Experimental Stroke Outcome across the Life Span , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[45]  C. Sommer,et al.  Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke , 2009, Nature Medicine.

[46]  B. Hoffer,et al.  Gene expression patterns in mouse cortical penumbra after focal ischemic brain injury and reperfusion , 2008, Journal of neuroscience research.

[47]  M. Pagano,et al.  Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer , 2008, Nature Reviews Cancer.

[48]  Kimberly A. Houser,et al.  Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats , 2008, Neurobiology of Aging.

[49]  T. Suuronen,et al.  Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging , 2008, Ageing Research Reviews.

[50]  S. Shioda,et al.  Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[51]  G. Donnan,et al.  1,026 Experimental treatments in acute stroke , 2006, Annals of neurology.

[52]  Gang Wang,et al.  Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity , 2006, Nature Medicine.

[53]  M. T. Hasan,et al.  IKK mediates ischemia-induced neuronal death , 2005, Nature Medicine.

[54]  M. Rausch,et al.  Recovery and brain reorganization after stroke in adult and aged rats , 2005, Annals of neurology.

[55]  C. Rosen,et al.  Influence of age on stroke outcome following transient focal ischemia. , 2005, Journal of neurosurgery.

[56]  M. Moskowitz,et al.  Exciting, radical, suicidal: how brain cells die after stroke. , 2005, Stroke.

[57]  K. Jin,et al.  Ischemia‐induced neurogenesis is preserved but reduced in the aged rodent brain , 2004, Aging cell.

[58]  Claudio L Bassetti,et al.  VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. , 2004, Brain : a journal of neurology.

[59]  P. Mcgeer,et al.  Inflammation and neurodegeneration in Parkinson's disease. , 2004, Parkinsonism & related disorders.

[60]  A. Reymond,et al.  TRIM9 is specifically expressed in the embryonic and adult nervous system , 2002, Mechanisms of Development.

[61]  Konrad Jamrozik,et al.  Long-Term Disability After First-Ever Stroke and Related Prognostic Factors in the Perth Community Stroke Study, 1989–1990 , 2002, Stroke.

[62]  T. Kadar,et al.  Aging has a complex effect on a rat model of ischemic stroke , 2002, Brain Research.

[63]  D. Stephenson,et al.  Transcription Factor Nuclear Factor-Kappa B is Activated in Neurons after Focal Cerebral Ischemia , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[64]  R. Maki,et al.  Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. , 1999, Trends in pharmacological sciences.

[65]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[66]  J. Flanagan,et al.  RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. , 2012, The Journal of molecular diagnostics : JMD.

[67]  Nature Neurology,et al.  Ischemic stroke in the elderly: an overview of evidence , 2010 .

[68]  M. Herrero,et al.  Parkinson's disease and inflammatory changes , 2009, Neurotoxicity Research.

[69]  Zhijian J. Chen Ubiquitin signalling in the NF-kappaB pathway. , 2005, Nature cell biology.

[70]  M. Mattson,et al.  NF-kappaB in neuronal plasticity and neurodegenerative disorders. , 2001, The Journal of clinical investigation.