Nanocomposites: From Fabrications to Electrochemical Bioapplications

Nanostructured materials including nanoparticles, nanowires, nanobands and carbon nanotubes (CNT) have been intensively investigated due to their fantastic ‘size effect’ and superior chemical and physical properties and functions. Nanocomposites can be fabricated not only with different nanostructured materials, but also with various biomolecules and conducting polymers to possess unique hybrid properties characteristic of neither the incorporated components nor the host matrices. The nanocomposites may be confined in nanoscale domains in one, two, or three dimensions for the unusual size-dependent behavior. The synergistic effects of the components lead to broad bioapplications of the nanocomposites such as biosensors, drug delivery systems and biofuel cells. A review of studies on nanocomposites from design, fabrication to their biocompatibility and electrochemical bioapplications is presented.

[1]  T. A. Desai,et al.  Micro- and nanoscale structures for tissue engineering constructs. , 2000, Medical engineering & physics.

[2]  Characterization of zinc oxide crystal nanowires grown by thermal evaporation of ZnS powders , 2003 .

[3]  Shengshui Hu,et al.  A multiwall carbon nanotubes film-modified carbon fiber ultramicroelectrode for the determination of nitric oxide radical in liver mitochondria. , 2005, Bioelectrochemistry.

[4]  Hua Dong,et al.  New nanocomposite materials reinforced with flax cellulose nanocrystals in waterborne polyurethane. , 2007, Biomacromolecules.

[5]  R. Kane,et al.  Polymer-nanotube-enzyme composites as active antifouling films. , 2007, Small.

[6]  G. S. Wilson,et al.  Electrochemical biosensors: recommended definitions and classification. , 2001, Biosensors & bioelectronics.

[7]  B. Mattiasson,et al.  Minimal-Fouling enzyme electrode for continuous flow measurement of whole blood lactate. , 1997, Biosensors & bioelectronics.

[8]  Félix Pariente,et al.  Design and characterization of a lactate biosensor based on immobilized lactate oxidase onto gold surfaces , 2006 .

[9]  Zhongfan Liu,et al.  Surfactant-directed polypyrrole/CNT nanocables: synthesis, characterization, and enhanced electrical properties. , 2004, Chemphyschem : a European journal of chemical physics and physical chemistry.

[10]  A. Ramanavičius,et al.  Redox enzyme – glucose oxidase – initiated synthesis of polypyrrole , 2006 .

[11]  H. P. Bennetto,et al.  Microbial fuel-cells , 1993 .

[12]  C. Melhuish,et al.  Comparative study of three types of microbial fuel cell , 2005 .

[13]  D. Gough,et al.  Simulations of the frequency response of implantable glucose sensors. , 2000, Analytical chemistry.

[14]  Qingji Xie,et al.  Electrochemical quartz crystal impedance study on the overoxidation of polypyrrole-carbon nanotubes composite film for amperometric detection of dopamine. , 2007, Biosensors & bioelectronics.

[15]  Lei Zhang,et al.  A review of anode catalysis in the direct methanol fuel cell , 2006 .

[16]  Donghua Zhang,et al.  Synthesis and applications of one-dimensional nano-structured polyaniline: An overview , 2006 .

[17]  V. Bulović,et al.  Electroluminescence from single monolayers of nanocrystals in molecular organic devices , 2002, Nature.

[18]  G. S. Wilson,et al.  Elimination of the acetaminophen interference in an implantable glucose sensor. , 1994, Analytical chemistry.

[19]  S. Nie,et al.  Quantum dot bioconjugates for ultrasensitive nonisotopic detection. , 1998, Science.

[20]  V. Zucolotto,et al.  Electroactive Nanostructured Membranes (ENM): Synthesis and Electrochemical Properties of Redox Mediator‐Modified Gold Nanoparticles Using a Dendrimer Layer‐by‐Layer Approach , 2007 .

[21]  Yu Chuan Liu,et al.  Strategy for the syntheses of isolated fine silver nanoparticles and polypyrrole/silver nanocomposites on gold substrates , 2006 .

[22]  C. Selomulya,et al.  Flame-sprayed superparamagnetic bare and silica-coated maghemite nanoparticles : Synthesis, characterization, and protein adsorption-desorption , 2006 .

[23]  G Burnstock,et al.  Receptors for purines and pyrimidines. , 1998, Pharmacological reviews.

[24]  Jinhan Cho,et al.  Nanostructured Electrochemical Sensor Based on Dense Gold Nanoparticle Films , 2003 .

[25]  J. Jansen,et al.  Biocompatibility evaluation of sol-gel coatings for subcutaneously implantable glucose sensors. , 2000, Biomaterials.

[26]  Chang Ming Li,et al.  Highly sensitive and selective method to detect dopamine in the presence of ascorbic acid by a new polymeric composite film. , 2007, Analytical biochemistry.

[27]  Charles M. Lieber,et al.  Covalently functionalized nanotubes as nanometre- sized probes in chemistry and biology , 1998, Nature.

[28]  X. Bian,et al.  Ultralight conductive carbon-nanotube-polymer composite. , 2007, Small.

[29]  Louis E. Brus,et al.  Binding of an Anti-Fullerene IgG Monoclonal Antibody to Single Wall Carbon Nanotubes , 2001 .

[30]  Paul Mulvaney,et al.  Solvent Refractive Index and Core Charge Influences on the Surface Plasmon Absorbance of Alkanethiolate Monolayer-Protected Gold Clusters , 2000 .

[31]  O. Wolfbeis,et al.  A Polyaniline with Near-Infrared Optical Response to Saccharides , 1999 .

[32]  S. Garg,et al.  Improved glucose excursions using an implantable real-time continuous glucose sensor in adults with type 1 diabetes. , 2004, Diabetes care.

[33]  Jianfeng Zang,et al.  Biocatalytic Generation of Ppy-Enzyme-CNT Nanocomposite: From Network Assembly to Film Growth , 2007 .

[34]  F. Bedioui,et al.  Electrochemical Nitric Oxide Sensors for Biological Samples – Principle, Selected Examples and Applications , 2003 .

[35]  Aiguo Wu,et al.  A method to construct a third-generation horseradish peroxidase biosensor: self-assembling gold nanoparticles to three-dimensional sol-gel network. , 2002, Analytical chemistry.

[36]  John H. T. Luong,et al.  Electrochemical detection of carbohydrates using copper nanoparticles and carbon nanotubes , 2004 .

[37]  Horst Weller,et al.  Biofunctionalization of Silica-Coated CdTe and Gold Nanocrystals , 2002 .

[38]  Guo-Li Shen,et al.  Amperometric glucose biosensor based on a surface treated nanoporous ZrO2/Chitosan composite film as immobilization matrix , 2004 .

[39]  Hua Dong,et al.  In situ studies of protein adsorptions on poly(pyrrole-co-pyrrole propylic acid) film by electrochemical surface plasmon resonance. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[40]  V. Zucolotto,et al.  Using Electrochemical Data to Obtain Energy Diagrams forLayer-By-Layer Films from Metallic Phthalocyanines , 2006, International Journal of Electrochemical Science.

[41]  Qiang Zhao,et al.  Electrochemical sensors based on carbon nanotubes , 2002 .

[42]  Chunzhong Li,et al.  Sensitive Biosensors Based on (Dendrimer Encapsulated Pt Nanoparticles)/Enzyme Multilayers , 2007 .

[43]  Klavs F. Jensen,et al.  Full Color Emission from II–VI Semiconductor Quantum Dot–Polymer Composites , 2000 .

[44]  Hans C. Fischer,et al.  Design and characterization of lysine cross-linked mercapto-acid biocompatible quantum dots , 2006 .

[45]  Jong-Ru Rau,et al.  Characterization of a polypyrrole microsensor for nitrate and nitrite ions , 1994 .

[46]  M. Freund,et al.  Potentiometric sensors based on the inductive effect on the pK(a) of poly(aniline): a nonenzymatic glucose sensor. , 2001, Journal of the American Chemical Society.

[47]  Wei Chen,et al.  Impedance labelless detection-based polypyrrole protein biosensor. , 2005, Frontiers in bioscience : a journal and virtual library.

[48]  Avelino Corma,et al.  From Microporous to Mesoporous Molecular Sieve Materials and Their Use in Catalysis. , 1997, Chemical reviews.

[49]  C. M. Li,et al.  Electrochemical Detection of Nitric Oxide on a SWCNT/RTIL Composite Gel Microelectrode , 2006 .

[50]  Gyoujin Cho,et al.  Comparative Investigation of Energy Relaxation Dynamics of Gold Nanoparticles and Gold−Polypyrrole Encapsulated Nanoparticles , 2003 .

[51]  Ya‐Ping Sun,et al.  Attaching Proteins to Carbon Nanotubes via Diimide-Activated Amidation , 2002 .

[52]  X. W. Sun,et al.  Enzymatic glucose biosensor based on ZnO nanorod array grown by hydrothermal decomposition , 2006 .

[53]  Gyu-Tae Kim,et al.  V2O5 nanofibre sheet actuators , 2003, Nature materials.

[54]  Galo J. A. A. Soler-Illia,et al.  Titania/Polypyrrole Hybrid Nanocomposites Built from In‐Situ Generated Organically Functionalized Nanoanatase Building Blocks , 2003 .

[55]  Qin Zhou,et al.  Template-synthesized cobalt porphyrin/polypyrrole nanocomposite and its electrocatalysis for oxygen reduction in neutral medium , 2007 .

[56]  G. Sukhorukov,et al.  Toward Encoding Combinatorial Libraries: Charge‐Driven Microencapsulation of Semiconductor Nanocrystals Luminescing in the Visible and Near IR , 2002 .

[57]  Zhiyong Tang,et al.  Nanostructured artificial nacre , 2003, Nature materials.

[58]  Huangxian Ju,et al.  Glucose sensor for flow injection analysis of serum glucose based on immobilization of glucose oxidase in titania sol-gel membrane. , 2003, Biosensors & bioelectronics.

[59]  Joseph Wang,et al.  Carbon nanotube--conducting-polymer composite nanowires. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[60]  Jian Wang,et al.  Covalent immobilization of glucose oxidase on conducting ultrananocrystalline diamond thin films , 2006 .

[61]  F. Béguin,et al.  Supercapacitors based on conducting polymers/nanotubes composites , 2006 .

[62]  Sejin Park,et al.  Nonenzymatic glucose detection using mesoporous platinum. , 2003, Analytical chemistry.

[63]  Itamar Willner,et al.  Long-range electrical contacting of redox enzymes by SWCNT connectors. , 2004, Angewandte Chemie.

[64]  James R. Durrant,et al.  Immobilisation and bioelectrochemistry of proteins on nanoporous TiO2 and ZnO films , 2001 .

[65]  Itamar Willner,et al.  "Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle , 2003, Science.

[66]  A. Ramanavičius,et al.  Polypyrrole-coated glucose oxidase nanoparticles for biosensor design , 2005 .

[67]  Qian Wang,et al.  An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. , 2004, Journal of the American Chemical Society.

[68]  M. Karim,et al.  RADIOLYTIC SYNTHESIS OF CONDUCTING POLYPYRROLE/CARBON NANOTUBE COMPOSITES , 2007 .

[69]  C. Koval,et al.  Electrode catalysis of the four-electron reduction of oxygen to water by dicobalt face-to-face porphyrins , 1980 .

[70]  Zhengdong Sun,et al.  Immobilization of uricase on ZnO nanorods for a reagentless uric acid biosensor , 2004 .

[71]  M. Meyerhoff,et al.  Thrombogenic properties of untreated and poly(ethylene oxide)-modified polymeric matrices useful for preparing intraarterial ion-selective electrodes. , 1995, Analytical chemistry.

[72]  Ludmila Buzhansky,et al.  Magnetically responsive carboxylated magnetite-polydipyrrole/polydicarbazole nanocomposites of core-shell morphology. Preparation, characterization, and use in DNA hybridization. , 2005, Journal of the American Chemical Society.

[73]  F C Walsh,et al.  Biofuel cells and their development. , 2006, Biosensors & bioelectronics.

[74]  C. M. Li,et al.  Synthesis and Electrical Transport of Novel Channel‐Structured β‐AgVO3 , 2007 .

[75]  Xiangqin Lin,et al.  Electrodeposition of Pt–Fe(III) nanoparticle on glassy carbon electrode for electrochemical nitric oxide sensor , 2005 .

[76]  J. Ying,et al.  Synthesis and Cell‐Imaging Applications of Glutathione‐Capped CdTe Quantum Dots , 2007 .

[77]  Gerald J. Meyer,et al.  Biological applications of high aspect ratio nanoparticles , 2004 .

[78]  H. Dai,et al.  Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. , 2001, Journal of the American Chemical Society.

[79]  Fwu-Shan Sheu,et al.  Selective and sensitive electrochemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites. , 2007, Analytica chimica acta.

[80]  Scott A. Miller,et al.  Rapid and efficient enzyme encapsulation in a dendrimer silica nanocomposite. , 2006, Macromolecular bioscience.

[81]  R. Lerner,et al.  Activation Volumes for Solid-Solid Transformations in Nanocrystals , 2001, Science.

[82]  D. Park,et al.  Improved fuel cell and electrode designs for producing electricity from microbial degradation. , 2003, Biotechnology and bioengineering.

[83]  J. Brennan,et al.  Fluorescence and physical characterization of sol–gel-derived nanocomposite films suitable for the entrapment of biomolecules , 2002 .

[84]  Chang Ming Li,et al.  Highly sensitive lactate biosensor by engineering chitosan/PVI-Os/CNT/LOD network nanocomposite. , 2007, Biosensors & bioelectronics.

[85]  Chang Q. Sun,et al.  Electrochemical thin film deposition of polypyrrole on different substrates , 2005 .

[86]  C. M. Li,et al.  Carbon nanotube/polyaniline composite as anode material for microbial fuel cells , 2007 .

[87]  Qiangbin Wang,et al.  Synthesis of deep-red-emitting cdse quantum dots and general non-inverse-square behavior of quantum confinement in CdSe quantum dots , 2006 .

[88]  Galen D. Stucky,et al.  MESOPOROUS SILICATE SEQUESTRATION AND RELEASE OF PROTEINS , 1999 .

[89]  Yuehe Lin,et al.  Low-potential stable NADH detection at carbon-nanotube-modified glassy carbon electrodes , 2002 .

[90]  T. Ebbesen,et al.  Helical Crystallization of Proteins on Carbon Nanotubes: A First Step towards the Development of New Biosensors. , 1999, Angewandte Chemie.

[91]  Weidong Yang,et al.  Shape control of CdSe nanocrystals , 2000, Nature.

[92]  R. Ramaraj,et al.  Electrochemically deposited nanostructured platinum on Nafion coated electrode for sensor applications , 2005 .

[93]  P. Vadgama,et al.  Open flow microperfusion: approach toin vivo glucose monitoring , 1995, Medical and Biological Engineering and Computing.

[94]  A. Dalmia,et al.  Electrochemical behavior of gold electrodes modified with self-assembled monolayers with an acidic end group for selective detection of dopamine , 1997 .

[95]  Xinyu Zhang,et al.  Synthesis of polyaniline nanofibers by "nanofiber seeding". , 2004, Journal of the American Chemical Society.

[96]  R Polzius,et al.  Optimization of biosensing using grating couplers: immobilization on tantalum oxide waveguides. , 1996, Biosensors & bioelectronics.

[97]  Cees Dekker,et al.  Nanotechnology: Carbon nanotubes with DNA recognition , 2002, Nature.

[98]  A. Bard,et al.  Fabrication and characterization of self-assembled spherical gold ultramicroelectrodes. , 1997, Analytical chemistry.

[99]  W. Verstraete,et al.  Microbial fuel cells: novel biotechnology for energy generation. , 2005, Trends in biotechnology.

[100]  C. Huber,et al.  Microengineered conducting composites from nanochannel templates , 1995 .

[101]  J. Justin Gooding,et al.  Achieving Direct Electrical Connection to Glucose Oxidase Using Aligned Single Walled Carbon Nanotube Arrays , 2005 .

[102]  Rudolf Wessel,et al.  Poly(pyrrole-metallodeuteroporphyrin)electrodes: towards electrochemical biomimetic devices , 2000 .

[103]  Paul M. George,et al.  Electrically Controlled Drug Delivery from Biotin‐Doped Conductive Polypyrrole , 2006 .

[104]  G. Bang,et al.  Electrocatalytic oxidation of sugars on silver-UPD single crystal gold electrodes in alkaline solutions , 2003 .

[105]  T. Mallouk,et al.  Combinatorial discovery of alloy electrocatalysts for amperometric glucose sensors. , 2001, Analytical chemistry.

[106]  M. Popall,et al.  Applications of hybrid organic–inorganic nanocomposites , 2005 .

[107]  Vahid Mottaghitalab,et al.  The influence of carbon nanotubes on mechanical and electrical properties of polyaniline fibers , 2005 .

[108]  Charles R. Martin,et al.  Template synthesis of polymeric and metal microtubules , 1991 .

[109]  J. Svendsen,et al.  The medicinal chemistry of short lactoferricin-based antibacterial peptides. , 2007, Current medicinal chemistry.

[110]  A. Ciszewski,et al.  Electrochemical detection of nitric oxide using polymer modified electrodes. , 2003, Talanta.

[111]  M. Devoret,et al.  Single-electron transfer in metallic nanostructures , 1992, Nature.

[112]  E. Song,et al.  Ion transport in conducting polymers doped with electroactive anions examined by EQCM , 2000 .

[113]  Hanxi Yang,et al.  Improved performances of E. coli-catalyzed microbial fuel cells with composite graphite/PTFE anodes , 2007 .

[114]  Chang Ming Li,et al.  Electrochemical impedance characterization of antibody-antigen interaction with signal amplification based on polypyrrole-streptavidin. , 2007, Biosensors & bioelectronics.

[115]  J. Vincent,et al.  Serial blood lactate levels can predict the development of multiple organ failure following septic shock. , 1996, American journal of surgery.

[116]  G. Chen,et al.  Electrochemical Capacitance of a Nanoporous Composite of Carbon Nanotubes and Polypyrrole , 2002 .

[117]  A Heller,et al.  "Wired" enzyme electrodes for amperometric determination of glucose or lactate in the presence of interfering substances. , 1994, Analytical chemistry.

[118]  J. Miltat,et al.  Small Is Beautiful , 1999, Science.

[119]  M. Shim,et al.  Functionalization of Carbon Nanotubes for Biocompatibility and Biomolecular Recognition , 2002 .

[120]  T. Swager,et al.  Conjugated polymer-based chemical sensors. , 2000, Chemical reviews.

[121]  T. Aida,et al.  Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles. , 2003 .

[122]  David Gough,et al.  A Continuous, Implantable Lactate Sensor , 1995 .

[123]  R Langer,et al.  Stimulation of neurite outgrowth using an electrically conducting polymer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[124]  S. E. San,et al.  Temperature dependency of electrical behaviors in single walled carbon nanotube/conducting polymer composites , 2007 .

[125]  C. Batt,et al.  Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[126]  S. Pearton,et al.  ZnO: growth, doping & processing , 2004 .

[127]  M. Darder,et al.  Relevance of polymer– and biopolymer–clay nanocomposites in electrochemical and electroanalytical applications , 2006 .

[128]  Bruce E. Logan,et al.  Microbial Fuel Cells , 2006 .

[129]  C. McNeil,et al.  Sensor-based measurements of the role and interactions of free radicals in cellular systems. , 2002, Journal of biotechnology.

[130]  P. Zambonin,et al.  Electrosynthesis and characterisation of nanostructured palladium–polypyrrole composites , 2000 .

[131]  L. Dao,et al.  A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide. , 2004, Biomaterials.

[132]  Younan Xia,et al.  One‐Dimensional Nanostructures: Synthesis, Characterization, and Applications , 2003 .

[133]  R. Hopkins,et al.  Initial postoperative serum lactate levels predict survival in children after open heart surgery , 1996, Intensive Care Medicine.

[134]  F Moussy,et al.  A ferric chloride pre-treatment to prevent calcification of Nafion membrane used for implantable biosensors. , 1999, Biosensors & bioelectronics.

[135]  John R. Reynolds,et al.  Use of Conducting Electroactive Polymers for Drug Delivery and Sensing of Bioactive Molecules. A Redox Chemistry Approach , 2000 .

[136]  Dusan Losic,et al.  Protein electrochemistry using aligned carbon nanotube arrays. , 2003, Journal of the American Chemical Society.

[137]  A. Walcarius,et al.  Voltammetric in situ investigation of an MCM-41-modified carbon paste electrode—a new sensor , 1998 .

[138]  M. Egashira,et al.  Effects of the surface treatment of the Al2O3 filler on the lithium electrode/solid polymer electrolyte interface properties , 2006 .

[139]  Qin Zhou,et al.  Efficient probe immobilization on poly (dimethylsiloxane) for sensitive detection of proteins. , 2005, Frontiers in bioscience : a journal and virtual library.

[140]  P. C. Biswas,et al.  Electro-oxidation of CO and methanol on graphite-based platinum electrodes combined with oxide-supported ultrafine gold particles , 1995 .

[141]  P. Zambonin,et al.  Flow injection analysis of L-lactate in milk and yoghurt by on-line microdialysis and amperometric detection at a disposable biosensor. , 2001, The Analyst.

[142]  Won Jun Sung,et al.  Glucose oxidase, lactate oxidase, and galactose oxidase enzyme electrode based on polypyrrole with polyanion/PEG/enzyme conjugate dopant , 2006 .

[143]  Yongfa Zhu,et al.  Size dependence of SiO2 particles enhanced glucose biosensor. , 2006, Talanta.

[144]  Zhiwei Zhu,et al.  Selective detection of dopamine in the presence of ascorbic acid and uric acid by a carbon nanotubes-ionic liquid gel modified electrode. , 2005, Talanta.

[145]  G. Gigli,et al.  Bright White‐Light‐Emitting Device from Ternary Nanocrystal Composites , 2006 .

[146]  D. Gough,et al.  Two-dimensional enzyme electrode sensor for glucose. , 1985, Analytical chemistry.

[147]  P Rolfe,et al.  Development of a haemocompatible pO2 sensor with phospholipid-based copolymer membrane. , 1996, Biosensors & bioelectronics.

[148]  G. Whitesides The 'right' size in nanobiotechnology , 2003, Nature Biotechnology.

[149]  C. M. Li,et al.  Tailoring Zinc Oxide Nanowires for High Performance Amperometric Glucose Sensor , 2007 .

[150]  C. M. Li,et al.  Nanostructured polyaniline/titanium dioxide composite anode for microbial fuel cells. , 2008, ACS nano.

[151]  V. S. Lee,et al.  Preparation of nano-tentacle polypyrrole with pseudo-molecular template for ATP incorporation. , 2007, Journal of biomedical materials research. Part A.

[152]  Zhongze Gu,et al.  Electrochemical Study on Synergistic Effect of the Blending of Nano TiO2 and PLA Polymer on the Interaction of Antitumor Drug with DNA , 2006 .

[153]  G. Ozin Nanochemistry: Synthesis in diminishing dimensions , 1992 .

[154]  Jing Zhao,et al.  Preparation and Defluorination Performance of Activated Cerium(IV) Oxide/SiMCM-41 Adsorbent in Water. , 2001, Journal of colloid and interface science.

[155]  Robert C. Haddon,et al.  Proton exchange membrane fuel cells with carbon nanotube based electrodes , 2004 .

[156]  C. M. Li,et al.  Morphology and electrochemistry of LiMn2O4 optimized by using different Mn-sources , 2007 .

[157]  S. Iijima Helical microtubules of graphitic carbon , 1991, Nature.

[158]  R. Smolenski,et al.  Purines, lactate and phosphate release from child and adult heart during cardioplegic arrest. , 1990, Clinica chimica acta; international journal of clinical chemistry.

[159]  E. Conte,et al.  Voltammetric peak separation of dopamine from uric acid in the presence of ascorbic acid at greater than ambient solution temperatures. , 2004, Analytical chemistry.

[160]  Chang Ming Li,et al.  Fabrication of Strongly Fluorescent Quantum Dot−Polymer Composite in Aqueous Solution , 2007 .

[161]  C. R. Martin,et al.  Smart nanotubes for bioseparations and biocatalysis. , 2002, Journal of the American Chemical Society.

[162]  Z. Pászti,et al.  Electronic structure of gold nanoparticles deposited on SiOx/Si(100) , 2002 .

[163]  Milo S. P. Shaffer,et al.  Carbon Nanotube and Polypyrrole Composites: Coating and Doping , 2000 .

[164]  G. Mayer,et al.  New classes of tough composite materials—Lessons from natural rigid biological systems , 2006 .

[165]  V. Zucolotto,et al.  Enhanced charge transport and incorporation of redox mediators in layer-by-layer films containing PAMAM-encapsulated gold nanoparticles. , 2006, The journal of physical chemistry. B.

[166]  Fwu-Shan Sheu,et al.  Nonenzymatic glucose detection using multi-walled carbon nanotube electrodes , 2004 .

[167]  S. Moncada,et al.  Vascular endothelial cells synthesize nitric oxide from L-arginine , 1988, Nature.

[168]  T. C. Chuang,et al.  Synthesis and Characterization of Gold/Polypyrrole Core−Shell Nanocomposites and Elemental Gold Nanoparticles Based on the Gold-Containing Nanocomplexes Prepared by Electrochemical Methods in Aqueous Solutions , 2003 .

[169]  J. Oni,et al.  Pyrrole functionalised metalloporphyrins as electrocatalysts for the oxidation of nitric oxide. , 2003, Talanta.

[170]  A. Patil,et al.  Fabrication of functional protein–organoclay lamellar nanocomposites by biomolecule-induced assembly of exfoliated aminopropyl-functionalized magnesium phyllosilicates , 2005 .

[171]  D. Park,et al.  Electricity Generation in Microbial Fuel Cells Using Neutral Red as an Electronophore , 2000, Applied and Environmental Microbiology.

[172]  D. Lovley,et al.  Electricity generation by direct oxidation of glucose in mediatorless microbial fuel cells , 2003, Nature Biotechnology.

[173]  Joseph Wang Carbon‐Nanotube Based Electrochemical Biosensors: A Review , 2005 .

[174]  J. A. Hubbell,et al.  Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors. , 1995, Biomaterials.

[175]  Qiang Zhao,et al.  Direct proteins electrochemistry based on ionic liquid mediated carbon nanotube modified glassy carbon electrode. , 2005, Frontiers in bioscience : a journal and virtual library.

[176]  Serge Cosnier,et al.  Affinity Biosensors Based on Electropolymerized Films , 2005 .

[177]  X. W. Sun,et al.  Zinc oxide nanocomb biosensor for glucose detection , 2006 .

[178]  Q. Bao,et al.  Functionalized multi-walled carbon nanotubes as affinity ligands , 2007 .

[179]  Zhongfan Liu,et al.  Conducting polymer/carbon nanotube composite films made by in situ electropolymerization using an ionic surfactant as the supporting electrolyte , 2005 .

[180]  Stefano Freguia,et al.  Microbial fuel cells: methodology and technology. , 2006, Environmental science & technology.

[181]  Xiaogang Peng,et al.  Stabilization of inorganic nanocrystals by organic dendrons. , 2002, Journal of the American Chemical Society.

[182]  K. Ramanathan,et al.  Bioaffinity sensing using biologically functionalized conducting-polymer nanowire. , 2005, Journal of the American Chemical Society.

[183]  Zhongfan Liu,et al.  Controllable synthesis of conducting polypyrrole nanostructures. , 2006, The journal of physical chemistry. B.

[184]  B. Ogorevc,et al.  Simultaneous measurement of dopamine and ascorbate at their physiological levels using voltammetric microprobe based on overoxidized poly(1,2-phenylenediamine)-coated carbon fiber. , 2001, Analytical chemistry.

[185]  Iqbal Gill,et al.  Bio-doped Nanocomposite Polymers: Sol-Gel Bioencapsulates , 2001 .

[186]  Qin Zhou,et al.  Covalently linked DNA/protein multilayered film for controlled DNA release. , 2007, Journal of colloid and interface science.

[187]  Xueji Zhang Real time and in vivo monitoring of nitric oxide by electrochemical sensors--from dream to reality. , 2004, Frontiers in bioscience : a journal and virtual library.

[188]  G. Maracas,et al.  Impedance labelless detection-based polypyrrole DNA biosensor. , 2005, Frontiers in bioscience : a journal and virtual library.

[189]  Derek R. Lovley,et al.  Bug juice: harvesting electricity with microorganisms , 2006, Nature Reviews Microbiology.

[190]  G. Ozin,et al.  Electroactive Mesoporous Yttria Stabilized Zirconia Containing Platinum or Nickel Oxide Nanoclusters: A New Class of Solid Oxide Fuel Cell Electrode Materials , 2001 .

[191]  S. Higson,et al.  Selective membranes for the construction and optimization of an amperometric oxalate enzyme electrode. , 1994, The Analyst.

[192]  R. Langer,et al.  Polyhistidine-PEG:DNA nanocomposites for gene delivery. , 2003, Biomaterials.

[193]  Na Li,et al.  New Antibody Immobilization Strategy Based on Gold Nanoparticles and Azure I/Multi-Walled Carbon Nanotube Composite Membranes for an Amperometric Enzyme Immunosensor , 2007 .

[194]  Itamar Willner,et al.  Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity. , 2005, Analytical chemistry.

[195]  Uri Banin,et al.  Growth and Properties of Semiconductor Core/Shell Nanocrystals with InAs Cores , 2000 .

[196]  Itamar Willner,et al.  Synthesis of Nanowires Using Dip‐Pen Nanolithography and Biocatalytic Inks , 2006 .