A genetic model for cardiac pattern formation and cell fate determination

[1]  K. Ocorr,et al.  Cardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila , 2000, Genesis.

[2]  R. Schulz,et al.  The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. , 1999, Development.

[3]  R. Bodmer,et al.  The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision. , 1999, Development.

[4]  S. Izumo,et al.  The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. , 1999, Development.

[5]  F. Grosveld,et al.  The transcription factor GATA6 is essential for early extraembryonic development. , 1999, Development.

[6]  Stephen S. Gisselbrecht,et al.  Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm. , 1998, Genes & development.

[7]  P. Krieg,et al.  Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. , 1998, Developmental biology.

[8]  E. Morrisey,et al.  GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. , 1998, Genes & development.

[9]  Wei Yan,et al.  Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. , 1998, Development.

[10]  D. Elliott,et al.  Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. , 1998, Development.

[11]  M. Fishman,et al.  Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Y. Jan,et al.  Asymmetric cell division: lessons from flies and worms. , 1998, Current opinion in genetics & development.

[13]  M. Frasch,et al.  Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. , 1998, Genes & development.

[14]  J. Seidman,et al.  Congenital heart disease caused by mutations in the transcription factor NKX2-5. , 1998, Science.

[15]  R. Bodmer,et al.  Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo , 1998, Mechanisms of Development.

[16]  R. Schwartz,et al.  GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression , 1998, Molecular and Cellular Biology.

[17]  Youngsook Lee,et al.  The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression , 1998, Molecular and Cellular Biology.

[18]  J. Seidman,et al.  Reduced penetrance, variable expressivity, and genetic heterogeneity of familial atrial septal defects. , 1998, Circulation.

[19]  H. Bellen,et al.  The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. , 1998, Development.

[20]  C. Doe,et al.  Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. , 1998, Development.

[21]  W. Chia,et al.  Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. , 1998, Genes & development.

[22]  Y. Jiang,et al.  Common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis. , 1998, Developmental genetics.

[23]  M. Frasch,et al.  Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. , 1998, Developmental genetics.

[24]  D. Durocher,et al.  Combinatorial interactions regulating cardiac transcription. , 1998, Developmental genetics.

[25]  G. Lyons,et al.  Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. , 1998, Developmental genetics.

[26]  P. Krieg,et al.  tinman-related genes expressed during heart development in Xenopus. , 1998, Developmental genetics.

[27]  R. Bodmer,et al.  Dual role for the zeste-white3/shaggy-encoded kinase in mesoderm and heart development of Drosophila. , 1998, Developmental genetics.

[28]  M. Frasch,et al.  Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. , 1997, Development.

[29]  M. Bate,et al.  Segregation of myogenic lineages in Drosophila requires numb. , 1997, Development.

[30]  M. Fishman,et al.  Parsing the Heart: Genetic Modules for Organ Assembly , 1997, Cell.

[31]  D. Durocher,et al.  The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors , 1997, The EMBO journal.

[32]  M. Frasch,et al.  ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors. , 1997, Development.

[33]  G. Eichele,et al.  Chicken Nkx-2.8: a novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm. , 1997, Developmental biology.

[34]  M. Leptin,et al.  Control of cell fates and segmentation in the Drosophila mesoderm. , 1997, Development.

[35]  M. Nemer,et al.  Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. , 1997, Development.

[36]  M. Fishman,et al.  Fashioning the vertebrate heart: earliest embryonic decisions. , 1997, Development.

[37]  C. Biben,et al.  Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. , 1997, Genes & development.

[38]  Y. Jan,et al.  Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. , 1997, Development.

[39]  E. Olson,et al.  Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. , 1997, Genes & development.

[40]  K Sigrist,et al.  GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. , 1997, Genes & development.

[41]  E. Morrisey,et al.  GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. , 1997, Developmental biology.

[42]  A. Lassar,et al.  A role for bone morphogenetic proteins in the induction of cardiac myogenesis. , 1997, Genes & development.

[43]  Y. Zou,et al.  CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. , 1997, Development.

[44]  A. Ghysen,et al.  Cell fate determination in Drosophila , 1997, Current Opinion in Neurobiology.

[45]  Kyu-Ho Lee,et al.  A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. , 1996, Developmental biology.

[46]  P. Lawrence,et al.  Segmentation and specification of the Drosophila mesoderm. , 1996, Genes & development.

[47]  B. Shilo,et al.  Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. , 1996, Genes & development.

[48]  Stephen S. Gisselbrecht,et al.  heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. , 1996, Genes & development.

[49]  R. Harvey.  NK-2 homeobox genes and heart development. , 1996, Developmental biology.

[50]  Sara Jacob,et al.  Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate , 1996, Current Biology.

[51]  J. Axelrod,et al.  The wingless signaling pathway is directly involved in Drosophila heart development. , 1996, Developmental biology.

[52]  E. Morrisey,et al.  GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. , 1996, Developmental biology.

[53]  Y. Jan,et al.  Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis , 1996, Neuron.

[54]  Y. Jan,et al.  Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch , 1996, Neuron.

[55]  C. Doe,et al.  Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates , 1996, Neuron.

[56]  D. Srivastava,et al.  Molecular Pathways Controlling Heart Development , 1996, Science.

[57]  Y. Jiang,et al.  The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. , 1996, Developmental biology.

[58]  A. Lassar,et al.  Induction of avian cardiac myogenesis by anterior endoderm. , 1995, Development.

[59]  P. Lawrence,et al.  Segmental patterning of heart precursors in Drosophila. , 1995, Development.

[60]  C. Goodman,et al.  Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. , 1995, Development.

[61]  N. Papalopulu,et al.  tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. , 1995, Development.

[62]  H. Lehrach,et al.  Expression of a Drosophila GATA Transcription Factor in Multiple Tissues in the Developing Embryos , 1995, The Journal of Biological Chemistry.

[63]  R. Bodmer,et al.  How many signals does it take? , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[64]  R. Bodmer,et al.  Origin and specification of type II sensory neurons in Drosophila. , 1995, Development.

[65]  Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. , 1995, Molecular and cellular biology.

[66]  Yoshiki Sasai,et al.  A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin , 1995, Nature.

[67]  Ruili Li,et al.  Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. , 1995, Genes & development.

[68]  R. Bodmer,et al.  Heart development in Drosophila requires the segment polarity gene wingless. , 1995, Developmental biology.

[69]  M. Frasch,et al.  Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo , 1995, Nature.

[70]  E. Bier,et al.  Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation , 1995, Cell.

[71]  Michael Bate,et al.  dpp induces mesodermal gene expression in Drosophila , 1994, Nature.

[72]  D. Wilson,et al.  The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells , 1994, Molecular and cellular biology.

[73]  D. Wilson,et al.  Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. , 1994, Developmental biology.

[74]  M. Nemer,et al.  A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription , 1994, Molecular and cellular biology.

[75]  T. Lints,et al.  XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. , 1994, Developmental biology.

[76]  Y. Jan,et al.  Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells , 1994, Cell.

[77]  P. Simpson,et al.  pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. , 1993, Development.

[78]  A. Michelson,et al.  A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. , 1993, Development.

[79]  L Hartley,et al.  Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. , 1993, Development.

[80]  I. Komuro,et al.  Csx: a murine homeobox-containing gene specifically expressed in the developing heart. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[81]  M. Frasch,et al.  tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. , 1993, Genes & development.

[82]  L. Zon,et al.  GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. , 1993, Development.

[83]  R. Bodmer.  The gene tinman is required for specification of the heart and visceral muscles in Drosophila. , 1993, Development.

[84]  W. Gelbart,et al.  Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[85]  A. Simcox,et al.  Allocation of the thoracic imaginal primordia in the Drosophila embryo. , 1993, Development.

[86]  S. Higashijima,et al.  Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. , 1993, Development.

[87]  C. Nüsslein-Volhard,et al.  The origin of pattern and polarity in the Drosophila embryo , 1992, Cell.

[88]  Gerald M. Rubin,et al.  The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins , 1991, Mechanisms of Development.

[89]  Y. Jan,et al.  A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. , 1990, Development.

[90]  Y. Jan,et al.  numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos , 1989, Cell.