Optimization of the modelling of longitudinal dose distributions for double-scattered proton beams in a commercially-available treatment planning system

The configuration of a treatment planning system (TPS) for double-scattering-based proton therapy requires many user inputs. Most of these are either gathered during the routine collection of commissioning data, or can be supplied by the equipment vendor; however, this is not true of all. In this study we developed a technique both to (a) expedite the extraction of those undetermined TPS parameters related to the range modulator wheels that can only otherwise be obtained by the time-consuming process of trial-and-error, and (b) demonstrate how, for a commonly-employed, commercially-available TPS, the judicious determination of such parameters can be used to optimize the resultant modelling of longitudinal dose distributions delivered by a double scattering proton therapy system. Our technique is simple to implement, robust in nature and also provides insight allowing parameters that must be contrived in that model to be related directly to physical aspects of the beam delivery system.

[1]  M Goitein,et al.  A pencil beam algorithm for proton dose calculations. , 1996, Physics in medicine and biology.

[2]  E Grusell,et al.  A general solution to charged particle beam flattening using an optimized dual-scattering-foil technique, with application to proton therapy beams. , 1994, Physics in medicine and biology.

[3]  J M Slater,et al.  The proton treatment center at Loma Linda University Medical Center: rationale for and description of its development. , 1992, International journal of radiation oncology, biology, physics.

[4]  Harald Paganetti,et al.  Relative biological effectiveness (RBE) values for proton beam therapy. , 2002, International journal of radiation oncology, biology, physics.

[5]  A. Kacperek Clinical Proton Dosimetry Part I: Beam Production, Beam Delivery and Measurement of Absorbed Dose (ICRU Report 59) , 2000 .

[6]  E. Pedroni,et al.  Dose calculation models for proton treatment planning using a dynamic beam delivery system: an attempt to include density heterogeneity effects in the analytical dose calculation. , 1999, Physics in medicine and biology.

[7]  Robert J. Schneider,et al.  Range modulators for protons and heavy ions , 1975 .

[8]  Hsiao-Ming Lu,et al.  Optimization of current modulation function for proton spread-out Bragg peak fields. , 2006, Medical physics.

[9]  B. Schaffner Proton dose calculation based on in-air fluence measurements , 2008, Physics in medicine and biology.

[10]  S. V. Bulanov Laser ion acceleration for hadron therapy , 2014, 2014 International Conference Laser Optics.

[11]  A M Koehler,et al.  Flattening of proton dose distributions for large-field radiotherapy. , 1977, Medical physics.