Effect of magnesium sulfate on the hemodynamic changes by laryngoscopy and endotracheal intubation

Background: Air way management by direct laryngoscopy and endotracheal intubation cause hemodynamic changes during analgesia. The researchers tried to reduce its effects that each of them has different success rate and still try to find a method or medicine to reduce these effects. Therefore, purpose of this study is to investigate Effect of magnesium sulfate on the hemodynamic changes by laryngoscopy and endotracheal intubation. Method: 90 patients in the age range 20-41 years old who were candid for elective surgery were selected in double blinded randomized, clinical trial study. All patients were is ASA class I and II. Patients were divided randomly to study and control groups then magnesium sulfate 20 (for study group) or normal saline (for control group) was administred. Systolic and diastolic blood pressure and pulse rate before and after analgesia and after laryngoscopy were recorded and then measured every 1 to 3 minutes. Data analysis was done by SPSS software. Results: There was no significant difference for change in diastolic blood pressure, systolic blood pressure and heart rate between the two groups(p>0.05), except in diastolic blood pressure after laryngoscopy(p=0.002). Conclusion: magnesium sulfate cannot prevent hemodynamic responses caused by laryngoscopy and intubation.

[1]  Suhrita Paul,et al.  Effects of magnesium sulfate on hemodynamic response to carbon dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy , 2013, Anesthesia, essays and researches.

[2]  Mohammad Amin Alipour,et al.  Hemodynamic changes occurring with tracheal intubation by direct laryngoscopy compared with intubating laryngeal mask airway in adults: A randomized comparison trial , 2013 .

[3]  N. Bharti,et al.  Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients. , 2013, Journal of clinical anesthesia.

[4]  S. Mohajerani,et al.  Effects of Intravenous Magnesium Sulfate and Lidocaine on Hemodynamic Variables Following Direct Laryngoscopy and Intubation in Elective Surgery Patients , 2013, Tanaffos.

[5]  G. N. Bashandy,et al.  Air-Q the Intubating Laryngeal Airway: Comparative study of hemodynamic stress responses to tracheal intubation via Air-Q and direct laryngoscopy , 2012 .

[6]  P. Rahimzadeh,et al.  Effects of Premedication with Metoprolol on Bleeding and Induced Hypotension in Nasal Surgery , 2012, Anesthesiology and pain medicine.

[7]  Sathees B. C. Chandra,et al.  Low-dose esmolol: hemodynamic response to endotracheal intubation in normotensive patients - , 2012 .

[8]  Y. Shin,et al.  Evaluation of dose effects of magnesium sulfate on rocuronium injection pain and hemodynamic changes by laryngoscopy and endotracheal intubation , 2011, Korean journal of anesthesiology.

[9]  N. Chatterjee,et al.  Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study , 2010, Indian journal of anaesthesia.

[10]  J. Henderson.  Airway Management in the Adult , 2010 .

[11]  C. Lee,et al.  Magnesium sulphate attenuates arterial pressure increase during laparoscopic cholecystectomy. , 2009, British journal of anaesthesia.

[12]  Wanchun Tang,et al.  Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation* , 2009, Critical care medicine.

[13]  Wang Shi-duan.  Effect of magnesium sulfate on the cardiovascular response and the stress response to endotracheal intubation , 2009 .

[14]  K. Yoo,et al.  Cardiovascular and arousal responses to laryngoscopy and tracheal intubation in patients with complete spinal cord injury. , 2009, British journal of anaesthesia.

[15]  Sathees B. C. Chandra,et al.  Clinical research Low-dose fentanyl: hemodynamic response to endotracheal intubation in normotensive patients , 2008 .

[16]  F. Xue,et al.  Different small‐dose remifentanil blunting the cardiovascular response to laryngoscopy and intubation in children: a randomized double‐blind comparison , 2008, European journal of anaesthesiology.

[17]  B. Uğur,et al.  Effects of Esmolol, Lidocaine and Fentanyl on Haemodynamic Responses to Endotracheal Intubation , 2007, Clinical drug investigation.

[18]  J. Takeda,et al.  Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction. , 2006, Acta anaesthesiologica Belgica.

[19]  Ranvinder Kaur,et al.  Comparative evaluation of different doses of propofol preceded by fentanyl on intubating conditions and pressor response during tracheal intubation without muscle relaxants , 2006, Paediatric anaesthesia.

[20]  N. Turgut,et al.  Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery. , 2005, British journal of anaesthesia.

[21]  C. Mazer,et al.  Comparison of bolus remifentanil versus bolus fentanyl for induction of anesthesia and tracheal intubation in patients with cardiac disease. , 2004, Journal of cardiothoracic and vascular anesthesia.

[22]  S. Lischinsky,et al.  Hemodynamic and catecholamine response to tracheal intubation: direct laryngoscopy compared with fiberoptic intubation. , 2003, Journal of clinical anesthesia.

[23]  Z. Salihoğlu,et al.  Comparison of effects of remifentanil, alfentanil and fentanyl on cardiovascular responses to tracheal intubation in morbidly obese patients. , 2002, European journal of anaesthesiology.

[24]  S. Bansal,et al.  Haemodynamic responses to laryngoscopy and intubation in patients with pregnancy-induced hypertension: effect of intravenous esmolol with or without lidocaine. , 2002, International journal of obstetric anesthesia.

[25]  Y. Hamaya,et al.  Differences in Cardiovascular Response to Airway Stimulation at Different Sites and Blockade of the Responses by Lidocaine , 2000, Anesthesiology.

[26]  D. Choi,et al.  Bupivacaine‐Sparing Effect of Fentanyl in Spinal Anesthesia for Cesarean Delivery , 2000, Regional anesthesia and pain medicine.