Type 17 T helper cells—origins, features and possible roles in rheumatic disease

[1]  C. Baecher-Allan,et al.  IL-17-producing human peripheral regulatory T cells retain suppressive function. , 2009, Blood.

[2]  D. Bending,et al.  Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. , 2009, The Journal of clinical investigation.

[3]  J. Renauld,et al.  Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. , 2009, Arthritis and rheumatism.

[4]  C. Tato,et al.  Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22 , 2009, The Journal of experimental medicine.

[5]  M. Veldhoen,et al.  Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells , 2009, The Journal of experimental medicine.

[6]  C. Elson,et al.  Late developmental plasticity in the T helper 17 lineage. , 2009, Immunity.

[7]  Yi-hong Wang,et al.  Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells , 2009, European journal of immunology.

[8]  L. Cosmi,et al.  TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells , 2009, European journal of immunology.

[9]  M. Huber,et al.  IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype , 2008, Proceedings of the National Academy of Sciences.

[10]  C. Dong Regulation and pro‐inflammatory function of interleukin‐17 family cytokines , 2008, Immunological reviews.

[11]  J. Kolls,et al.  Th17 cytokines and mucosal immunity , 2008, Immunological reviews.

[12]  D. Vignali,et al.  Interleukin‐35: odd one out or part of the family? , 2008, Immunological reviews.

[13]  T. Naka,et al.  Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. , 2008, Arthritis and rheumatism.

[14]  M. Oukka Th17 cells in immunity and autoimmunity , 2008, Annals of the rheumatic diseases.

[15]  S. Alzabin,et al.  Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells , 2008, The Journal of experimental medicine.

[16]  Irma Joosten,et al.  Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. , 2008, Blood.

[17]  L. Cosmi,et al.  Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor , 2008, The Journal of experimental medicine.

[18]  A. Fischer,et al.  Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells , 2008, The Journal of experimental medicine.

[19]  S. Tangye,et al.  Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 , 2008, The Journal of experimental medicine.

[20]  B. Segal,et al.  IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition , 2008, The Journal of experimental medicine.

[21]  David E. Anderson,et al.  IL-21 and TGF-β are required for differentiation of human TH17 cells , 2008, Nature.

[22]  Stefan Jenisch,et al.  Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. , 2008, The Journal of investigative dermatology.

[23]  Y. Iwakura,et al.  Development of Proteoglycan-Induced Arthritis Is Independent of IL-171 , 2008, The Journal of Immunology.

[24]  E. Barillot,et al.  A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses , 2008, Nature Immunology.

[25]  M. Lebwohl,et al.  Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2) , 2008, The Lancet.

[26]  A. Kimball,et al.  Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) , 2008, The Lancet.

[27]  D. Littman,et al.  The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.

[28]  Y. Iwakura,et al.  Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category , 2008, The Journal of experimental medicine.

[29]  Jay K Kolls,et al.  The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation , 2022 .

[30]  W. Paul,et al.  Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome , 2008, Nature.

[31]  E. Wawrousek,et al.  Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells1 , 2008, The Journal of Immunology.

[32]  E. Lubberts,et al.  IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? , 2008, Cytokine.

[33]  Lisa C. Zaba,et al.  Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses , 2007, The Journal of experimental medicine.

[34]  J. O’Shea,et al.  Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. , 2007, Seminars in immunology.

[35]  R. Misra,et al.  Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. , 2007, The Journal of rheumatology.

[36]  D. Hommes,et al.  Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. , 2007, Immunity.

[37]  Graham M Lord,et al.  Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes , 2007, Proceedings of the National Academy of Sciences.

[38]  Kathleen M. Smith,et al.  Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.

[39]  P. Gisondi,et al.  Lower limb enthesopathy in patients with psoriasis without clinical signs of arthropathy: a hospital-based case–control study , 2007, Annals of the rheumatic diseases.

[40]  L. Cosmi,et al.  Phenotypic and functional features of human Th17 cells , 2007, The Journal of experimental medicine.

[41]  F. Sallusto,et al.  Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells , 2007, Nature Immunology.

[42]  Frank O. Nestle,et al.  Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis , 2007, Human Genetics.

[43]  W. Strober,et al.  Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.

[44]  D. G. Zisoulis,et al.  Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1 , 2007, The Journal of Immunology.

[45]  J. Kolls,et al.  After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease? , 2007, International immunopharmacology.

[46]  M. Hegen,et al.  Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. , 2007, Arthritis and rheumatism.

[47]  P. Schirmacher,et al.  Targeting of the Transcription Factor STAT4 by Antisense Phosphorothioate Oligonucleotides Suppresses Collagen-Induced Arthritis1 , 2007, The Journal of Immunology.

[48]  P. Valdez,et al.  Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis , 2007, Nature.

[49]  Satoshi Tanaka,et al.  T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis , 2007, The Journal of experimental medicine.

[50]  Akira Yamaguchi,et al.  Regulation of osteoclast differentiation and function by the CaMK-CREB pathway , 2006, Nature Medicine.

[51]  Judy H. Cho,et al.  A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene , 2006, Science.

[52]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[53]  I. Frazer God's gift to women: the human papillomavirus vaccine. , 2006, Immunity.

[54]  S. Nakae,et al.  IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis1 , 2006, The Journal of Immunology.

[55]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[56]  J. Edmonds,et al.  Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). , 2006, Arthritis and rheumatism.

[57]  J. Bos,et al.  In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin , 2006, The Journal of Immunology.

[58]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[59]  M. Neurath,et al.  Both IL‐12p70 and IL‐23 are synthesized during active Crohn's disease and are down‐regulated by treatment with anti‐IL‐12 p40 monoclonal antibody , 2006, Inflammatory bowel diseases.

[60]  R. Gold,et al.  Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. , 2005, Cellular immunology.

[61]  T. Mcclanahan,et al.  Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation , 2003, The Journal of experimental medicine.

[62]  S. Nakae,et al.  Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1 , 2003, The Journal of Immunology.

[63]  S. Nakae,et al.  IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[64]  R. Kastelein,et al.  Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain , 2003, Nature.

[65]  B. Kirkham,et al.  Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. , 2002, Arthritis and rheumatism.

[66]  H. Kikutani,et al.  Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. , 2001, Blood.

[67]  P. Miossec,et al.  IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. , 1999, Journal of immunology.

[68]  S. Romagnani,et al.  The Th1/Th2 paradigm. , 1997, Immunology today.

[69]  J. Banchereau,et al.  T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines , 1996, The Journal of experimental medicine.

[70]  M. Seldin,et al.  Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. , 1995, Journal of immunology.

[71]  S. Romagnani Human TH1 and TH2 subsets: doubt no more. , 1991, Immunology today.

[72]  R. Jonsson,et al.  Treatment with gamma-interferon triggers the onset of collagen arthritis in mice. , 1988, Arthritis and rheumatism.

[73]  S. Sriram,et al.  Suppression of murine collagen-induced arthritis with monoclonal anti-Ia antibodies and augmentation with IFN-gamma. , 1988, Journal of immunology.

[74]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[75]  G. Galbraith Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome , 2009 .

[76]  David E. Anderson,et al.  OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells , 2008 .

[77]  A. Andoh,et al.  Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. , 2004, Clinical immunology.

[78]  L Adorini,et al.  The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. , 1998, Annual review of immunology.