Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages.

[1]  R. Rintoul,et al.  Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer. , 2023, Cancer cell.

[2]  Hu Li,et al.  Senescent alveolar macrophages promote early-stage lung tumorigenesis. , 2023, Cancer cell.

[3]  M. Karin,et al.  An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory , 2022, Nature Cell Biology.

[4]  M. Gorospe,et al.  Nuclear morphology is a deep learning biomarker of cellular senescence , 2022, Nature Aging.

[5]  M. Wadsworth,et al.  Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis , 2022, bioRxiv.

[6]  Yanqing Xu,et al.  Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis. , 2022, Cell reports.

[7]  Richard M. Giadone,et al.  Expression Levels of Lamin A or C Are Critical to Nuclear Maturation, Functional Responses, and Gene Expression Profiles in Differentiating Mouse Neutrophils , 2022, ImmunoHorizons.

[8]  B. Becher,et al.  Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice , 2021, Nature Aging.

[9]  B. Gelfand,et al.  A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling , 2021, Nature Communications.

[10]  J. Galon,et al.  Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion , 2021, Cell.

[11]  M. Piel,et al.  Nuclear deformations, from signaling to perturbation and damage. , 2021, Current opinion in cell biology.

[12]  E. Kenigsberg,et al.  Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells , 2021, Nature.

[13]  N. LaRusso,et al.  An aged immune system drives senescence and ageing of solid organs , 2021, Nature.

[14]  J. Hoeijmakers,et al.  The central role of DNA damage in the ageing process , 2021, Nature.

[15]  A. Sharpe,et al.  The aging lung: Physiology, disease, and immunity , 2021, Cell.

[16]  D. Aran,et al.  Molecular programs of fibrotic change in aging human lung , 2021, Nature Communications.

[17]  P. Kubes,et al.  Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis , 2020, Cell.

[18]  C. Rius,et al.  Lamin A/C and the Immune System: One Intermediate Filament, Many Faces , 2020, International journal of molecular sciences.

[19]  B. Fierz,et al.  BAF restricts cGAS on nuclear DNA to prevent innate immune activation , 2020, Science.

[20]  Irving L. Weissman,et al.  A single-cell transcriptomic atlas characterizes ageing tissues in the mouse , 2020, Nature.

[21]  T. Mustelin,et al.  Distal lung epithelial progenitor cell function declines with age , 2020, Scientific Reports.

[22]  V. Werth,et al.  Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly , 2020, EMBO reports.

[23]  R. Superfine,et al.  Nuclear Deformation Causes DNA Damage by Increasing Replication Stress , 2020, Current Biology.

[24]  M. Desco,et al.  T cells with dysfunctional mitochondria induce multimorbidity and premature senescence , 2020, Science.

[25]  Y. Kluger,et al.  Single-cell connectomic analysis of adult mammalian lungs , 2019, Science Advances.

[26]  L. Laurent,et al.  Mechanisms of nuclear content loading to exosomes , 2019, Science Advances.

[27]  C. Schmitt,et al.  Cellular Senescence: Defining a Path Forward , 2019, Cell.

[28]  F. Ginhoux,et al.  Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells , 2019, Cell.

[29]  I. Amit,et al.  Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner , 2019, Cell.

[30]  R. Greenberg,et al.  Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest , 2019, bioRxiv.

[31]  D. Wagner,et al.  NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture , 2019, Proceedings of the National Academy of Sciences.

[32]  Y. Dor,et al.  Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3 , 2019, Cell reports.

[33]  T. Angelini,et al.  Repair of nuclear ruptures requires barrier-to-autointegration factor , 2019, The Journal of cell biology.

[34]  F. Ginhoux,et al.  Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches , 2019, Science.

[35]  M. Piel,et al.  Reconstitution of cell migration at a glance , 2019, Journal of Cell Science.

[36]  N. Manel,et al.  The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus , 2019, Cell reports.

[37]  C. Plass,et al.  LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells , 2018, Genome Biology.

[38]  Lucas R. Smith,et al.  Nuclear rupture at sites of high curvature compromises retention of DNA repair factors , 2018, The Journal of cell biology.

[39]  B. Ryffel,et al.  Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice , 2018, Scientific Reports.

[40]  L. Wallrath,et al.  Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells , 2018, bioRxiv.

[41]  Fabian J Theis,et al.  An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics , 2018, Nature Communications.

[42]  K. M. Choi,et al.  Aging and anatomical variations in lung tissue stiffness. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[43]  O. Lantz,et al.  Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node , 2018, Nature Communications.

[44]  Denis Torre,et al.  eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks , 2018, Nucleic Acids Res..

[45]  A. Shilatifard,et al.  Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span , 2017, The Journal of experimental medicine.

[46]  S. Gollnick,et al.  p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli , 2017, Aging.

[47]  N. Kaminski,et al.  Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice , 2017, The Journal of Immunology.

[48]  L. Zender,et al.  Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence , 2017, Nature Cell Biology.

[49]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[50]  Zhijian J. Chen,et al.  cGAS is essential for cellular senescence , 2017, Proceedings of the National Academy of Sciences.

[51]  Andrea J. Liu,et al.  DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration , 2017, Current Biology.

[52]  J. Gilhodes,et al.  Quantification of Pulmonary Fibrosis in a Bleomycin Mouse Model Using Automated Histological Image Analysis , 2017, PloS one.

[53]  Grace X. Y. Zheng,et al.  Massively parallel digital transcriptional profiling of single cells , 2016, Nature Communications.

[54]  Jan Lammerding,et al.  Nuclear envelope rupture and repair during cancer cell migration , 2016, Science.

[55]  R. Voituriez,et al.  ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death , 2016, Science.

[56]  Peter J. Campbell,et al.  Chromothripsis and Kataegis Induced by Telomere Crisis , 2015, Cell.

[57]  P. Linsley,et al.  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data , 2015, Genome Biology.

[58]  Tony T. Jiang,et al.  Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna Dhe mice , 2015, Aging cell.

[59]  R. Foisner,et al.  Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation. , 2015, Annual review of biochemistry.

[60]  K. Ishii,et al.  Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells. , 2015, Cell reports.

[61]  A. Regev,et al.  Spatial reconstruction of single-cell gene expression , 2015, Nature Biotechnology.

[62]  S. Nobs,et al.  The development and function of lung-resident macrophages and dendritic cells , 2014, Nature Immunology.

[63]  N. Hacohen,et al.  Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. , 2014, Cell reports.

[64]  K. Karjalainen,et al.  Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity , 2014, European journal of immunology.

[65]  Alex K. Heer,et al.  Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection , 2014, PLoS pathogens.

[66]  A. Prince,et al.  Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity , 2014, Nature.

[67]  M. Sieweke,et al.  Beyond Stem Cells: Self-Renewal of Differentiated Macrophages , 2013, Science.

[68]  C. Bassing,et al.  Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations , 2013, Cell cycle.

[69]  Youngjo Kim,et al.  Generation and characterization of a conditional deletion allele for Lmna in mice. , 2013, Biochemical and biophysical research communications.

[70]  Dennis E. Discher,et al.  Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation , 2013, Science.

[71]  Peter D. Adams,et al.  Lysosome-mediated processing of chromatin in senescence , 2013, The Journal of cell biology.

[72]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[73]  M. Cybulsky,et al.  Faculty Opinions recommendation of Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. , 2013 .

[74]  David J. Arenillas,et al.  oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets , 2012, G3: Genes | Genomes | Genetics.

[75]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[76]  Björn Schumacher,et al.  The p53 network: cellular and systemic DNA damage responses in aging and cancer. , 2012, Trends in genetics : TIG.

[77]  M. Hetzer,et al.  Transient nuclear envelope rupturing during interphase in human cancer cells , 2012, Nucleus.

[78]  W. D. De Vos,et al.  Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. , 2011, Human molecular genetics.

[79]  Hussein Mansour,et al.  Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats , 2011, PloS one.

[80]  Judith Klumperman,et al.  Trafficking and function of the tetraspanin CD63. , 2009, Experimental cell research.

[81]  M. Sixt,et al.  Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels , 2009, The Journal of experimental medicine.

[82]  D. Sinclair,et al.  Aging: past, present and future , 2009, Aging.

[83]  Y. Hiraoka,et al.  Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly , 2008, Journal of Cell Science.

[84]  H. Worman,et al.  "Laminopathies": a wide spectrum of human diseases. , 2007, Experimental cell research.

[85]  Frédérick A. Mallette,et al.  DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. , 2006, Molecular biology of the cell.

[86]  R. Alon,et al.  Immune cell migration in inflammation: present and future therapeutic targets , 2005, Nature Immunology.

[87]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[88]  Mark Coles,et al.  Transgenic mice with hematopoietic and lymphoid specific expression of Cre , 2003, European journal of immunology.

[89]  A. Berns,et al.  Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer , 2001, Nature Genetics.

[90]  J. Nikolich-Žugich The twilight of immunity: emerging concepts in aging of the immune system , 2017, Nature Immunology.