Cardiotoxicity with Modern Local Anaesthetics

[1]  J. Plummer,et al.  Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep , 2001, British journal of pharmacology.

[2]  A. Decaux,et al.  Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart. , 2000, Anesthesiology.

[3]  P. Frascarolo,et al.  A Comparison of the Electrocardiographic Cardiotoxic Effects of Racemic Bupivacaine, Levobupivacaine, and Ropivacaine in Anesthetized Swine , 2000, Anesthesia and analgesia.

[4]  S. Alahuhta,et al.  Two instances of central nervous system toxicity in the same patient following repeated ropivacaine‐induced brachial plexus block , 2000, Acta anaesthesiologica Scandinavica.

[5]  G. Edelman,et al.  Bupivacaine Inhibits Acylcarnitine Exchange in Cardiac Mitochondria , 2000, Anesthesiology.

[6]  A. C. Primavesi ? Tolerability of Large-Dose Intravenous Levobupivacaine in Sheep , 2000 .

[7]  D. Kopacz,et al.  Accidental intravenous levobupivacaine. , 1999, Anesthesia and analgesia.

[8]  G. Hempelmann,et al.  Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve. , 1999, Anesthesiology.

[9]  G. Lyons,et al.  Relative potencies of bupivacaine and ropivacaine for analgesia in labour. , 1999, British journal of anaesthesia.

[10]  M. Columb,et al.  Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. , 1998, Anesthesiology.

[11]  R. Gristwood,et al.  A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. , 2002, British journal of clinical pharmacology.

[12]  A. Bindoli,et al.  Mitochondrial effects of L-ropivacaine, a new local anesthetic. , 1998, Biochemical pharmacology.

[13]  G. Lyons,et al.  Epidural pain relief in labour: potencies of levobupivacaine and racemic bupivacaine. , 1998, British journal of anaesthesia.

[14]  V. Wilson,et al.  Rilmenidine reveals differences in the pharmacological characteristics of prejunctional α2‐adrenoceptors in the guinea‐pig, rat and pig , 1998, British journal of pharmacology.

[15]  M. Jiang,et al.  Differential Effects of Bupivacaine on Cardiac K Channels: Role of Channel Inactivation and Subunit Composition in Drug—Channel Interaction , 1998, Journal of cardiovascular electrophysiology.

[16]  R. Gristwood,et al.  Comparison of the Cardiotioxic Effects of Bupivacaine, Levobupivacaine and Ropivacaine.an in vitro Study in Guinea-Pig and Human Cardiac Muscle , 1998, Regional Anesthesia & Pain Medicine.

[17]  J. Mazat,et al.  Comparison of the Effects of Bupivacaine and Ropivacaine on Heart Cell Mitochondrial Bioenergetics , 1998, Anesthesiology.

[18]  B. Veering,et al.  Cardiovascular and Central Nervous System Effects of Intravenous Levobupivacaine and Bupivacaine in Sheep , 1998, Anesthesia and analgesia.

[19]  B. Veering,et al.  Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. , 1998 .

[20]  L. Mather,et al.  Central Nervous System Toxicity Attributable to Epidural Ropivacaine Hydrochloride , 1998, Anaesthesia and intensive care.

[21]  K.,et al.  Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. , 1997, British journal of anaesthesia.

[22]  J. Tamargo,et al.  Effects of Ropivacaine on a Potassium Channel (hKv1.5) Cloned from Human Ventricle , 1997, Anesthesiology.

[23]  L. Fernandes,et al.  S(−) Bupivacaine and RS(±)Bupivacaine: A Comparison of Effects on the Right and Left Atria of the Rat. , 1997, Regional Anesthesia & Pain Medicine.

[24]  B. Graf,et al.  Stereospecific Effect of Bupivacaine Isomers on Atrioventricular Conduction in the Isolated Perfused Guinea Pig Heart , 1997, Anesthesiology.

[25]  Q. Hogan,et al.  Local Anesthetic Toxicity: An Update , 1996, Regional Anesthesia & Pain Medicine.

[26]  J. Tamargo,et al.  Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. , 1995, Circulation.

[27]  J. Tamargo,et al.  Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. , 1995, Biophysical journal.

[28]  K. Samii,et al.  Myocardial uptake of bupivacaine: II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart. , 1993, Anesthesia and analgesia.

[29]  J. Kantelip,et al.  Myocardial uptake of bupivacaine: I. Pharmacokinetics and pharmacodynamics of lidocaine and bupivacaine in the isolated perfused rabbit heart. , 1993, Anesthesia and Analgesia.

[30]  H. Wulf,et al.  [The potential dependence of the effect of bupivacaine and ropivacaine on the heart. In-vitro studies on the effect of local anesthetics on the force of contraction and the action potential in left guinea pig atria]. , 1993, Der Anaesthesist.

[31]  R. Prielipp,et al.  Bupivacaine Inhibits Cyclic‐3', 5'‐Adenosine Monophosphate Production A Possible Contributing Factor to Cardiovascular Toxicity , 1993, Anesthesiology.

[32]  G. Strichartz,et al.  Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action? , 1992, Anesthesiology.

[33]  P. Peray,et al.  Experimental evidence in favor of role of intracellular actions of bupivacaine in myocardial depression. , 1992, Anesthesia and analgesia.

[34]  M. Behbehani,et al.  Enantiomer-Specific Effects of an Intravenously Administered Arrhythmogenic Dose of Bupivacaine on Neurons of the Nucleus Tractus Solitarius and the Cardiovascular System in the Anesthetized Rat , 1992, Regional Anesthesia & Pain Medicine.

[35]  B. Covino,et al.  Chronotropic and Inotropic Effects of Ropivacaine, Bupivacaine, and Lidocaine in the Spontaneously Beating and Electrically Paced Isolated, Perfused Rabbit Heart , 1992, Regional Anesthesia & Pain Medicine.

[36]  B. Covino,et al.  Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. , 1991, Anesthesia and analgesia.

[37]  L. Mather Disposition of mepivacaine and bupivacaine enantiomers in sheep. , 1991, British journal of anaesthesia.

[38]  E. Carmeliet,et al.  Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea‐pig papillary muscle , 1991, British journal of pharmacology.

[39]  B. Covino,et al.  Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. , 1990, Anesthesiology.

[40]  B. Covino,et al.  Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog , 1989, Anesthesia and analgesia.

[41]  J. Brugada,et al.  In Vitro Study on Mechanisms of Bupivacaine‐Induced Depression of Myocardial Contractility , 1989, Anesthesia and analgesia.

[42]  Alistair Lee,et al.  Acute Toxicity of Ropivacaine Compared with That of Bupivacaine , 1989, Anesthesia and analgesia.

[43]  M. Berman ROPIVACAINE AND THE CARDIAC SODIUM CURRENT , 1989 .

[44]  W. Runciman,et al.  Myocardial and Cerebral Drug Concentrations and the Mechanisms of Death after Fatal Intravenous Doses of Lidocaine, Bupivacaine, and Ropivacaine in the Sheep , 1989, Anesthesia and analgesia.

[45]  W. Runciman,et al.  Hemodynamic and Central Nervous System Effects of Intravenous Bolus Doses of Lidocaine, Bupivacaine, and Ropivacaine in Sheep , 1989, Anesthesia and analgesia.

[46]  P. Allen,et al.  Contractility Effects of Local Anesthetics in the Presence of Sodium Channel Blockade , 1989, Regional anesthesia and pain medicine.

[47]  J. Sánchez-Chapula Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes. , 1988, European journal of pharmacology.

[48]  B. Akerman,et al.  Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103) , 1988, Acta anaesthesiologica Scandinavica.

[49]  P. Arlock Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (Vmax). , 1988, Pharmacology & toxicology.

[50]  G. Kasten,et al.  Comparison of Resuscitation of Sheep and Dogs after Bupivacaine‐Induced Cardiovascular Collapse , 1986, Anesthesia and analgesia.

[51]  S. Reiz,et al.  Cardiotoxicity of local anaesthetic agents. , 1986, British journal of anaesthesia.

[52]  C. Lynch Depression of Myocardial Contractility In Vitro by Bupivacaine, Etidocaine, and Lidocaine , 1986, Anesthesia and analgesia.

[53]  P. Honerjäger The contribution of Na channel block to the negative inotropic effect of antiarrhythmic drugs. , 1986, Basic research in cardiology.

[54]  H. Feldman,et al.  Direct Chronotropic and Inotropic Effects of Local Anesthetic Agents in Isolated Guinea Pig Atria , 1982, Regional Anesthesia & Pain Medicine.

[55]  B. Covino,et al.  Effect of Local Anesthetic Agents on Cardiac Conduction and Contractility , 1981, Regional Anesthesia & Pain Medicine.

[56]  J. Prentiss Cardiac arrest following caudal anesthesia. , 1979, Anesthesiology.

[57]  G A Albright,et al.  Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. , 1979, Anesthesiology.

[58]  G. Tucker,et al.  Cardiovascular and Subjective Central Nervous System Effects of Long-Acting Local Anaesthetics in Man , 1979, Anaesthesia and intensive care.

[59]  K. Dhunér,et al.  Studies on the duration of local anaesthesia: structure/activity relationships in a series of homologous local anaesthetics. , 2009, Acta pharmacologica et toxicologica.

[60]  L. Mather,et al.  Bupivacaine (Marcaine®): An Evaluation of its Tissue and Systemic Toxicity in Humans , 1977, Acta anaesthesiologica Scandinavica.

[61]  G. Åberg Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. , 1972, Acta pharmacologica et toxicologica.

[62]  L. Mather,et al.  The intravenous toxicity and clearance of bupivacaine in man , 1971, Clinical pharmacology and therapeutics.

[63]  L. Jorfeldt,et al.  THE EFFECT OF LOCAL ANAESTHETICS ON THE CENTRAL CIRCULATION AND RESPIRATION IN MAN AND DOG1),2) , 1968, Acta anaesthesiologica Scandinavica.