A comparative study of semi- and self-supervised semantic segmentation of biomedical microscopy data

In recent years, Convolutional Neural Networks (CNNs) have become the state-of-the-art method for biomedical image analysis. However, these networks are usually trained in a supervised manner, requiring large amounts of labelled training data. These labelled data sets are often difficult to acquire in the biomedical domain. In this work, we validate alternative ways to train CNNs with fewer labels for biomedical image segmentation using. We adapt two semi- and self-supervised image classification methods and analyse their performance for semantic segmentation of biomedical microscopy images.

[1]  Nathalie Harder,et al.  An Objective Comparison of Cell Tracking Algorithms , 2017, Nature Methods.

[2]  Quoc V. Le,et al.  Randaugment: Practical automated data augmentation with a reduced search space , 2019, 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW).

[3]  Quoc V. Le,et al.  AutoAugment: Learning Augmentation Strategies From Data , 2019, 2019 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).

[4]  Alan C. Evans,et al.  BigBrain: An Ultrahigh-Resolution 3D Human Brain Model , 2013, Science.

[5]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[6]  Nathalie Harder,et al.  A benchmark for comparison of cell tracking algorithms , 2014, Bioinform..

[7]  Seyed-Ahmad Ahmadi,et al.  V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation , 2016, 2016 Fourth International Conference on 3D Vision (3DV).

[8]  Quoc V. Le,et al.  Unsupervised Data Augmentation for Consistency Training , 2019, NeurIPS.

[9]  Peter Bankhead,et al.  QuPath: Open source software for digital pathology image analysis , 2017, Scientific Reports.

[10]  Demis Hassabis,et al.  A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play , 2018, Science.

[11]  Xu Ji,et al.  Invariant Information Clustering for Unsupervised Image Classification and Segmentation , 2018, 2019 IEEE/CVF International Conference on Computer Vision (ICCV).

[12]  Huaiyu Zhu On Information and Sufficiency , 1997 .

[13]  Anne E Carpenter,et al.  Annotated high-throughput microscopy image sets for validation , 2012, Nature Methods.

[14]  Sébastien Ourselin,et al.  Generalised Dice overlap as a deep learning loss function for highly unbalanced segmentations , 2017, DLMIA/ML-CDS@MICCAI.

[15]  Masoumeh Haghpanahi,et al.  Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network , 2019, Nature Medicine.