Acute liver failure is regulated by MYC- and microbiome-dependent programs

[1]  M. Mann,et al.  A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver , 2020, Omics : a journal of integrative biology.

[2]  L. Bolund,et al.  Single-Cell Transcriptome Atlas of Murine Endothelial Cells , 2020, Cell.

[3]  C. Ponting,et al.  Resolving the fibrotic niche of human liver cirrhosis at single cell level , 2019, Nature.

[4]  F. Tacke,et al.  Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis , 2019, Cells.

[5]  R. Schwabe,et al.  The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. , 2019, The Journal of clinical investigation.

[6]  V. Brunton,et al.  The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype , 2018, Science Advances.

[7]  Christoph Hafemeister,et al.  Comprehensive integration of single cell data , 2018, bioRxiv.

[8]  Francesco Asnicar,et al.  QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science , 2018 .

[9]  Gary D Bader,et al.  Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations , 2018, Nature Communications.

[10]  J. Zhong,et al.  TAK1 mediates excessive autophagy via p38 and ERK in cisplatin‐induced acute kidney injury , 2018, Journal of cellular and molecular medicine.

[11]  K. Messer,et al.  Proteomic Analysis Reveals IRAK4 As a Therapeutic Target in Chronic Lymphocytic Leukemia , 2017 .

[12]  F. Tacke,et al.  Liver macrophages in tissue homeostasis and disease , 2017, Nature Reviews Immunology.

[13]  A. Phillips,et al.  Immunofluorescence identifies distinct subsets of endothelial cells in the human liver , 2017, Scientific Reports.

[14]  H. Jaeschke,et al.  The impact of sterile inflammation in acute liver injury , 2017, Journal of clinical and translational research.

[15]  I. Amit,et al.  Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations , 2016, Cell.

[16]  I. N. Crispe,et al.  Infiltrating monocytes in liver injury and repair , 2016, Clinical & translational immunology.

[17]  Stefan Rose-John,et al.  IL-6 pathway in the liver: From physiopathology to therapy. , 2016, Journal of hepatology.

[18]  S. Dooley,et al.  TGF‐β signalling and liver disease , 2016, The FEBS journal.

[19]  W. Lieb,et al.  Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis , 2016, Gut.

[20]  O. Soehnlein,et al.  Neutrophil heterogeneity: implications for homeostasis and pathogenesis. , 2016, Blood.

[21]  A. Eliopoulos,et al.  TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury , 2016, The Journal of Immunology.

[22]  D. Ciocan,et al.  Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease , 2015, Gut.

[23]  Fabian J. Theis,et al.  destiny: diffusion maps for large-scale single-cell data in R , 2015, Bioinform..

[24]  Michelle C. Schaeffer,et al.  Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase , 2015, Cell Death Discovery.

[25]  Piero Carninci,et al.  A draft network of ligand–receptor-mediated multicellular signalling in human , 2015, Nature Communications.

[26]  J. Lieberman,et al.  Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2 , 2015, Cell reports.

[27]  M. Damaj,et al.  A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference* , 2015, The Journal of Biological Chemistry.

[28]  R. Schwabe,et al.  High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers , 2015, Nature Protocols.

[29]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[30]  P. Vogt,et al.  Inhibitor of MYC identified in a Kröhnke pyridine library , 2014, Proceedings of the National Academy of Sciences.

[31]  T. Mayadas,et al.  The multifaceted functions of neutrophils. , 2014, Annual review of pathology.

[32]  M. Netea,et al.  CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver , 2013, PloS one.

[33]  R. Hanzlik,et al.  Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. , 2012, Chemical research in toxicology.

[34]  Raul Rabadan,et al.  Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. , 2012, Cancer cell.

[35]  E. Seki,et al.  Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms , 2012, Front. Physio..

[36]  Richard A. Flavell,et al.  Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.

[37]  Richard A. Flavell,et al.  NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis , 2011, Cell.

[38]  B. Neel,et al.  MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. , 2011, The Journal of clinical investigation.

[39]  Hartmut Jaeschke,et al.  Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts , 2011, Journal of gastroenterology and hepatology.

[40]  P. Kubes,et al.  Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation , 2010, Science.

[41]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[42]  C. B. Pickett,et al.  The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress* , 2009, Journal of Biological Chemistry.

[43]  M. Frederick,et al.  Potent and Broad-Spectrum Antimicrobial Activity of CXCL14 Suggests an Immediate Role in Skin Infections1 , 2009, The Journal of Immunology.

[44]  D. Koller,et al.  The Immunological Genome Project: networks of gene expression in immune cells , 2008, Nature Immunology.

[45]  Yosuke Osawa,et al.  TLR4 enhances TGF-β signaling and hepatic fibrosis , 2007, Nature Medicine.

[46]  J. Campisi,et al.  Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.

[47]  J. Lindon,et al.  Pharmaco-metabonomic phenotyping and personalized drug treatment , 2006, Nature.

[48]  K. Nakahira,et al.  A Protective Role of Interleukin 11 on Hepatic Injury in Acute Endotoxemia , 2004, Shock.

[49]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[50]  D. Laskin,et al.  Role of CCR2 in macrophage migration into the liver during acetaminophen‐induced hepatotoxicity in the mouse , 2002, Hepatology.

[51]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[52]  T. Thomas,et al.  Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension , 2002, Gut.

[53]  Richard Moreau,et al.  Liver sinusoidal endothelial cells: Physiology and role in liver diseases. , 2017, Journal of hepatology.

[54]  K. Böker,et al.  Akutes Leberversagen , 2001, Der Internist.