Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants
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J. Bond | M. Greenblatt | J. G. Beaudet | J. Gump | K. Godin | L. Trombley | J. Koh | M S Greenblatt | J P Bond | J G Beaudet | J R Gump | K S Godin | L Trombley | J Koh | J. Beaudet | JG Beaudet | JR Gump | KS Godin | JP Bond
[1] E. Hovig,et al. CDKN2A (p16INK4A) somatic and germline mutations , 1996, Human mutation.
[2] N. Hayward,et al. Functional reassessment of P16 variants using a transfection‐based assay , 1999, International journal of cancer.
[3] Z. Yang,et al. Approximate methods for estimating the pattern of nucleotide substitution and the variation of substitution rates among sites. , 1996, Molecular biology and evolution.
[4] Y. Ina,et al. New methods for estimating the numbers of synonymous and nonsynonymous substitutions , 1995, Journal of Molecular Evolution.
[5] J. Struewing,et al. A single genetic origin for the G101W CDKN2A mutation in 20 melanoma-prone families. , 2000, American journal of human genetics.
[6] W. Yarbrough,et al. Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors. , 1999, Journal of the National Cancer Institute.
[7] S Henikoff,et al. Performance evaluation of amino acid substitution matrices , 1993, Proteins.
[8] M. Miller,et al. Understanding human disease mutations through the use of interspecific genetic variation. , 2001, Human molecular genetics.
[9] J. V. Moran,et al. Initial sequencing and analysis of the human genome. , 2001, Nature.
[10] R. DePinho,et al. The INK4A/ARF locus and its two gene products. , 1999, Current opinion in genetics & development.
[11] D. Cooper,et al. Determinants of the factor IX mutational spectrum in haemophilia B: an analysis of missense mutations using a multi-domain molecular model of the activated protein , 1994, Human Genetics.
[12] G. Peters,et al. Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information , 1999, Oncogene.
[13] Wojciech Makalowski,et al. Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features , 1999, Oncogene.
[14] M. Boguski,et al. Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[15] Philip D. Jeffrey,et al. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a , 1998, Nature.
[16] P. Pollock,et al. Compilation of somatic mutations of the CDKN2 gene in human cancers: Non‐random distribution of base substitutions , 1996, Genes, chromosomes & cancer.