Role of necroptosis in spinal cord injury and its therapeutic implications

[1]  W. Lai,et al.  Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells. , 2022, Chemical research in toxicology.

[2]  R. Shroff,et al.  Current and emerging therapies for advanced biliary tract cancers. , 2021, The lancet. Gastroenterology & hepatology.

[3]  Xinli Hu,et al.  GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation , 2021, Oxidative medicine and cellular longevity.

[4]  T. Kanneganti,et al.  Programming inflammatory cell death for therapy. , 2021, Pharmacology & therapeutics.

[5]  W. Su,et al.  Necroptosis: A Novel Pathway in Neuroinflammation , 2021, Frontiers in Pharmacology.

[6]  R. Elisei,et al.  Thyroid Cancers: From Surgery to Current and Future Systemic Therapies through Their Molecular Identities , 2021, International journal of molecular sciences.

[7]  B. Fiani,et al.  Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration , 2021, Neurospine.

[8]  Su Zhongren,et al.  Jia-Ji Electro-Acupuncture Improves Locomotor Function With Spinal Cord Injury by Regulation of Autophagy Flux and Inhibition of Necroptosis , 2021, Frontiers in Neuroscience.

[9]  T. Motawi,et al.  Ameliorative Effect of Necrosulfonamide in a Rat Model of Alzheimer's Disease: Targeting Mixed Lineage Kinase Domain-like Protein-Mediated Necroptosis. , 2020, ACS chemical neuroscience.

[10]  A. Buchan,et al.  Growth Differentiation Factor-11 Causes Neurotoxicity During Ischemia in vitro , 2020, Frontiers in Neurology.

[11]  J. Klubo-Gwiezdzinska,et al.  Novel Targeted Therapies for Metastatic Thyroid Cancer—A Comprehensive Review , 2020, Cancers.

[12]  L. McCullough,et al.  Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice , 2020, Aging.

[13]  Xiao-Jing Wang,et al.  The neuroprotective and neurorestorative effects of growth differentiation factor 11 in cerebral ischemic injury , 2020, Brain Research.

[14]  W. Ding,et al.  Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibition. , 2020, European review for medical and pharmacological sciences.

[15]  Hongxiang Chen,et al.  Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation , 2020, Cell Death & Disease.

[16]  Yang Wang,et al.  Necrosulfonamide Ameliorates Neurological Impairment in Spinal Cord Injury by Improving Antioxidative Capacity , 2020, Frontiers in Pharmacology.

[17]  E. Itoi,et al.  B-RAFV600E Inhibitor Dabrafenib Attenuates RIPK3-Mediated Necroptosis and Promotes Functional Recovery after Spinal Cord Injury , 2019, Cells.

[18]  Xin-hua Yin,et al.  Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats , 2019, Journal of Neuroinflammation.

[19]  N. Frangogiannis,et al.  The Role of the TGF-β Superfamily in Myocardial Infarction , 2019, Front. Cardiovasc. Med..

[20]  Yang Wang,et al.  RIP3 inhibition protects locomotion function through ameliorating mitochondrial antioxidative capacity after spinal cord injury. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[21]  Chao Yang,et al.  The role of necroptosis in cancer biology and therapy , 2019, Molecular Cancer.

[22]  M. Tremblay,et al.  Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury , 2019, Nature Communications.

[23]  N. Yang,et al.  RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice , 2018, Journal of Translational Medicine.

[24]  Jingcheng Wang,et al.  Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition. , 2018, World neurosurgery.

[25]  M. Lipinski,et al.  Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis , 2018, Cell Death & Disease.

[26]  Junying Yuan,et al.  Necroptosis in development and diseases , 2018, Genes & development.

[27]  Lei Zheng,et al.  Pyroptosis and its relationship to atherosclerosis. , 2018, Clinica chimica acta; international journal of clinical chemistry.

[28]  Jin Wu,et al.  Necrostatin-1 Mitigates Endoplasmic Reticulum Stress After Spinal Cord Injury , 2017, Neurochemical Research.

[29]  M. Sofroniew,et al.  Cell biology of spinal cord injury and repair. , 2017, The Journal of clinical investigation.

[30]  A. Ronkainen,et al.  Traumatic cervical spinal cord injury: a prospective clinical study of laryngeal penetration and aspiration , 2017, Spinal Cord.

[31]  Peter Vandenabeele,et al.  Initiation and execution mechanisms of necroptosis: an overview , 2017, Cell Death and Differentiation.

[32]  Yonghua Liu,et al.  Upregulation of PSMB4 is Associated with the Necroptosis after Spinal Cord Injury , 2016, Neurochemical Research.

[33]  B. Padanilam,et al.  Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis? , 2016, Cellular and Molecular Life Sciences.

[34]  Heng Ma,et al.  Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury , 2016, Molecular Neurodegeneration.

[35]  L. Zhu,et al.  Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury , 2016, Spinal Cord.

[36]  D. Green,et al.  Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis , 2015, Cell Death and Differentiation.

[37]  J. Wang,et al.  Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury , 2015, Neuroscience.

[38]  E. Itoi,et al.  Upregulation of the receptor-interacting protein 3 expression and involvement in neural tissue damage after spinal cord injury in mice , 2015, BMC Neuroscience.

[39]  H. Yang,et al.  Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury , 2015, Neuroscience.

[40]  Paul G Ekert,et al.  The molecular relationships between apoptosis, autophagy and necroptosis. , 2015, Seminars in cell & developmental biology.

[41]  S. Elkabes,et al.  Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord , 2014, Brain, Behavior, and Immunity.

[42]  W. Alexander,et al.  Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death , 2014, Proceedings of the National Academy of Sciences.

[43]  B. Festoff.  Designing drugs that encourage spinal cord injury healing , 2014, Expert opinion on drug discovery.

[44]  J. Schwab,et al.  The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury , 2014, Experimental Neurology.

[45]  Z. Miao,et al.  The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury , 2014, Cell Death and Disease.

[46]  S. Zhang,et al.  Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury , 2014, Neuroscience.

[47]  G. Ju,et al.  Spinal cord contusion , 2014, Neural regeneration research.

[48]  Jiahuai Han,et al.  Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death , 2013, Cell Research.

[49]  W. Tzaan,et al.  Effects of the combined administration of vitamins C and E on the oxidative stress status and programmed cell death pathways after experimental spinal cord injury , 2013, Spinal Cord.

[50]  V. Bracchi-Ricard,et al.  Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression , 2014, Journal of Neuroinflammation.

[51]  S. Fulda.  The mechanism of necroptosis in normal and cancer cells , 2013, Cancer biology & therapy.

[52]  Tracy J. Yuen,et al.  M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination , 2013, Nature Neuroscience.

[53]  A. Pant,et al.  Dietary Antioxidant, Quercetin, Protects Sertoli‐Germ Cell Coculture from Atrazine‐Induced Oxidative Damage , 2012, Journal of biochemical and molecular toxicology.

[54]  F. Northington,et al.  Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia–ischemia , 2012, Neuroscience.

[55]  Kenta Moriwaki,et al.  The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis , 2012, Cell.

[56]  R. Ransohoff,et al.  Innate immunity in the central nervous system. , 2012, The Journal of clinical investigation.

[57]  Xiaodong Wang,et al.  Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase , 2012, Cell.

[58]  Yuqiong Liang,et al.  Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway , 2011, Proceedings of the National Academy of Sciences.

[59]  Zsuzsanna A. Dunai,et al.  Necroptosis: Biochemical, Physiological and Pathological Aspects , 2011, Pathology & Oncology Research.

[60]  Wei Zhang,et al.  An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide , 2011, Neuroscience Research.

[61]  Hongxin Dong,et al.  Bone Marrow Mesenchymal Stem Cells and Electroacupuncture Downregulate the Inhibitor Molecules and Promote the Axonal Regeneration in the Transected Spinal Cord of Rats , 2011, Cell transplantation.

[62]  Xingshun Xu,et al.  Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury , 2010, Brain Research.

[63]  Xiuxiu Sun,et al.  Effects of grape pomace antioxidant extract on oxidative stress and inflammation in diet induced obese mice. , 2010, Journal of agricultural and food chemistry.

[64]  Jessica K. Alexander,et al.  Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord , 2009, The Journal of Neuroscience.

[65]  Alexei Degterev,et al.  Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway , 2008, Cell.

[66]  A. Bast,et al.  Health effects of quercetin: from antioxidant to nutraceutical. , 2008, European journal of pharmacology.

[67]  Alexei Degterev,et al.  Identification of RIP1 kinase as a specific cellular target of necrostatins. , 2008, Nature chemical biology.

[68]  D. Yellon,et al.  Necrostatin: A Potentially Novel Cardioprotective Agent? , 2007, Cardiovascular Drugs and Therapy.

[69]  P. Popovich,et al.  Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury , 2007, Journal of neurochemistry.

[70]  Jianhong Luo,et al.  Shikonin circumvents cancer drug resistance by induction of a necroptotic death , 2007, Molecular Cancer Therapeutics.

[71]  S. L. Mehta,et al.  Molecular targets in cerebral ischemia for developing novel therapeutics , 2007, Brain Research Reviews.

[72]  G. Barton,et al.  Emerging roles of pseudokinases. , 2006, Trends in cell biology.

[73]  Jeh-Ping Liu.  The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord , 2006, Development.

[74]  Alexei Degterev,et al.  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury , 2005, Nature chemical biology.

[75]  M. Beattie,et al.  Cell death in models of spinal cord injury. , 2002, Progress in brain research.

[76]  Brian Seed,et al.  Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule , 2000, Nature Immunology.

[77]  Se-Jin Lee,et al.  Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11 , 1999, Nature Genetics.