Patient-specific atrium models for training and pre-procedure surgical planning

Minimally invasive cardiac procedures requiring a trans-septal puncture such as atrial ablation and MitraClip® mitral valve repair are becoming increasingly common. These procedures are performed on the beating heart, and require clinicians to rely on image-guided techniques. For cases of complex or diseased anatomy, in which fluoroscopic and echocardiography images can be difficult to interpret, clinicians may benefit from patient-specific atrial models that can be used for training, surgical planning, and the validation of new devices and guidance techniques. Computed tomography (CT) images of a patient’s heart were segmented and used to generate geometric models to create a patient-specific atrial phantom. Using rapid prototyping, the geometric models were converted into physical representations and used to build a mold. The atria were then molded using tissue-mimicking materials and imaged using CT. The resulting images were segmented and used to generate a point cloud data set that could be registered to the original patient data. The absolute distance of the two point clouds was compared and evaluated to determine the model’s accuracy. The result when comparing the molded model point cloud to the original data set, resulted in a maximum Euclidean distance error of 4.5 mm, an average error of 0.5 mm and a standard deviation of 0.6 mm. Using our workflow for creating atrial models, potential complications, particularly for complex repairs, may be accounted for in pre-operative planning. The information gained by clinicians involved in planning and performing the procedure should lead to shorter procedural times and better outcomes for patients.

[1]  Ralf Sodian,et al.  Three-dimensional printing in cardiac surgery and interventional cardiology: a single-centre experience. , 2015, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[2]  F. Rybicki,et al.  Applications of 3D printing in cardiovascular diseases , 2016, Nature Reviews Cardiology.

[3]  J. Maessen,et al.  Preoperative planning with three-dimensional reconstruction of patient's anatomy, rapid prototyping and simulation for endoscopic mitral valve repair. , 2016, Interactive cardiovascular and thoracic surgery.

[4]  Stefan Weber,et al.  Three-dimensional printing of models for preoperative planning and simulation of transcatheter valve replacement. , 2012, The Annals of thoracic surgery.

[5]  J. Gorman,et al.  Three-dimensional ultrasound-derived physical mitral valve modeling. , 2014, The Annals of thoracic surgery.

[6]  Gabriel Taubin,et al.  A signal processing approach to fair surface design , 1995, SIGGRAPH.

[7]  D. Ross,et al.  The rapid prototyping of anatomic models in pulmonary atresia. , 2006, The Journal of thoracic and cardiovascular surgery.

[8]  Alberto Redaelli,et al.  Is it possible to assess the best mitral valve repair in the individual patient? Preliminary results of a finite element study from magnetic resonance imaging data. , 2014, The Journal of thoracic and cardiovascular surgery.

[9]  Martin O Culjat,et al.  A review of tissue substitutes for ultrasound imaging. , 2010, Ultrasound in medicine & biology.

[10]  Israel Valverde,et al.  Three-dimensional printed models in congenital heart disease , 2016, The International Journal of Cardiovascular Imaging.

[11]  W. Manning,et al.  Three-dimensional printing of mitral valve using echocardiographic data. , 2015, JACC. Cardiovascular imaging.

[12]  Marija Vukicevic,et al.  3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions , 2017, Annals of Biomedical Engineering.

[13]  Stefan Weber,et al.  Stereolithographic models for surgical planning in congenital heart surgery. , 2007, The Annals of thoracic surgery.

[14]  Mark D. Huffman,et al.  AHA Statistical Update Heart Disease and Stroke Statistics — 2012 Update A Report From the American Heart Association WRITING GROUP MEMBERS , 2010 .

[15]  Matthew S. Jackson,et al.  Replicating Patient-Specific Severe Aortic Valve Stenosis With Functional 3D Modeling , 2015, Circulation. Cardiovascular imaging.

[16]  T. Peters,et al.  Poly(vinyl alcohol) cryogel phantoms for use in ultrasound and MR imaging , 2004, Physics in medicine and biology.

[17]  Masayuki Fukuzawa,et al.  Simulative operation on congenital heart disease using rubber-like urethane stereolithographic biomodels based on 3D datasets of multislice computed tomography. , 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[18]  Paul J. Besl,et al.  A Method for Registration of 3-D Shapes , 1992, IEEE Trans. Pattern Anal. Mach. Intell..

[19]  M. Biase,et al.  Left Atrial Appendage Closure Guided by 3D Printed Cardiac Reconstruction: Emerging Directions and Future Trends , 2016, Journal of cardiovascular electrophysiology.

[20]  Catherine Klersy,et al.  Correction of mitral regurgitation in nonresponders to cardiac resynchronization therapy by MitraClip improves symptoms and promotes reverse remodeling. , 2011, Journal of the American College of Cardiology.