Influence of Sublethal Lead Concentrations on Glucose, Serum Enzymes and Ion Levels in Tilapia (Oreochromis mossambicus)

In this study, alterations in glucose, blood enzymes (alkaline phosphatase (ALP), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate aminotransferase (AST)) and serum ion (P, Mg, Cl, Ca, Fe) levels were investigated in Tilapia (Oreochromis mossambicus), which were semi-statically exposed to different lead concentrations in vivo. The fish were exposed to low (0.5 mg/L), medium (2.5 mg/L) and high (5 mg/L) concentrations of lead during 14 days. At the end of the experiment, biochemical blood parameters such as glucose, ALP, LDH, AST, chloride and magnesium increased (p<0.05). While, LDL and calcium levels decreased (p<0.05); ALT, cholesterol, albumin, iron and phosphor were fluctuated (p<0.05). Consequently, it was found that exposure of O. mossambicus to lead concentrations affected serum biochemical parameters negatively.

[1]  M. Yousef,et al.  Study of the protective effect of ascorbic acid against the toxicity of stannous chloride on oxidative damage, antioxidant enzymes and biochemical parameters in rabbits. , 2007, Toxicology.

[2]  C. Landriscina,et al.  Changes in liver enzyme activity in the teleost Sparus aurata in response to cadmium intoxication. , 1999, Ecotoxicology and environmental safety.

[3]  L. Tamer,et al.  Copper and Lead Accumulation in Tissues of a Freshwater Fish Tilapia zillii and Its Effects on the Branchial Na,K-ATPase Activity , 1999, Bulletin of environmental contamination and toxicology.

[4]  A. Dangé Changes in carbohydrate metabolism in tilapia, Oreochromis (Sarotherodon) mossambicus, during short-term exposure to different types of pollutants , 1986 .

[5]  C. Wood,et al.  Renal responses to acute lead waterborne exposure in the freshwater rainbow trout (Oncorhynchus mykiss). , 2006, Aquatic toxicology.

[6]  K. Jamil,et al.  ACID AND ALKALINE PHOSPHATASE ACTIVITIES IN A NOVEL PHOSPHOROTHIONATE (RPR-11) TREATED MALE AND FEMALE RATS. EVIDENCE OF DOSE AND TIME-DEPENDENT RESPONSE , 2000, Drug and chemical toxicology.

[7]  W. Marshall,et al.  Na(+), Cl(-), Ca(2+) and Zn(2+) transport by fish gills: retrospective review and prospective synthesis. , 2002, The Journal of experimental zoology.

[8]  K. Subhadra,et al.  In vivo effects of cadmium on some enzyme activities in tissues of the freshwater catfish, Heteropneustes fossilis. , 1985, Environmental research.

[9]  N. Smith,et al.  Acute and chronic toxicity of lead to rainbow trout salmo gairdneri, in hard and soft water , 1976 .

[10]  M. Johansson-Sjöbeck,et al.  Effects of inorganic lead on delta-aminolevulinic acid dehydratase activity and hematological variables in the rainbow trout,Salmo gairdnerii , 1979, Archives of environmental contamination and toxicology.

[11]  Ȧ. Larsson,et al.  A field study of physiological effects on fish in lead‐contaminated lakes , 1986 .

[12]  S. Yılmaz,et al.  Impacts of sublethal lead exposure on the hemato-immunological parameters in tilapia (Oreochromis mossambicus) , 2013 .

[13]  H. Kay Environmental Health Criteria , 1980 .

[14]  C. Wood,et al.  Ionoregulatory disruption as the acute toxic mechanism for lead in the rainbow trout (Oncorhynchus mykiss). , 2003, Aquatic toxicology.

[15]  M. Akbulut,et al.  Effects of Waterborne Lead Exposure in Mozambique Tilapia: Oxidative Stress, Osmoregulatory Responses, and Tissue Accumulation. , 2015, Journal of aquatic animal health.

[16]  Murray Logan,et al.  Biostatistical design and analysis using R: a practical guide , 2012 .

[17]  Richard D Handy,et al.  Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects. , 2007, Aquatic toxicology.

[18]  D. Bruno,et al.  Susceptibility of Atlantic halibut, Hippoglossus hippoglossus (L.) to infection with typical and atypical Aeromonas salmonicida , 1999 .