Thyroid, bradycardic and hypothermic effects of perfluoro-n-decanoic acid in rats.

A single ip injection of perfluoro-n-decanoic acid (PFDA) to male Wistar rats resulted in an initially rapid, then gradual decrease in food consumption and a parallel loss of body weight. Body temperatures and resting heart rates were significantly depressed by PFDA treatment. As early as 12 h following a single dose of PFDA, serum thyroxine (T4) levels were significantly reduced and remained depressed throughout the 8 day study. Serum triiodothyronine (T3) was reduced by 35% 12 h following PFDA treatment and remained at that level throughout the study. These preliminary data suggest that an action on the thyroid axis may be an early primary response to PFDA and that some of the observed subsequent effects may in part be secondary to the change in thyroid hormone levels.

[1]  M E Andersen,et al.  The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids. , 1983, Toxicology and applied pharmacology.

[2]  H. Kohno,et al.  Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats , 1982, Pharmacology Biochemistry and Behavior.

[3]  S. Suzuki,et al.  Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Peterson,et al.  2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Weight Loss: A Proposed Mechanism , 1983 .

[5]  E. Braunwald,et al.  Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium. , 1967, The Journal of clinical investigation.

[6]  F. A. Ubel,et al.  Health status of plant workers exposed to fluorochemicals--a preliminary report. , 1980, American Industrial Hygiene Association journal.

[7]  F. Ismail-Beigi,et al.  Thyroid thermogenesis and active sodium transport. , 1974, Recent progress in hormone research.

[8]  S. Mccann,et al.  Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH). , 1977, Endocrinology.

[9]  A. Schonbrunn,et al.  Mechanism of thyroid hormone inhibition of thyrotropin-releasing hormone action. , 1981, Endocrinology.

[10]  I. Sipes,et al.  Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration. , 1983, Toxicology and applied pharmacology.

[11]  H. Bryce.  CHAPTER 4 – Industrial and Utilitarian Aspects of Fluorine Chemistry , 1964 .