Mechanism and regulation of immunoglobulin isotype switching.

[1]  F. Alt,et al.  Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. de Waal Malefyt,et al.  Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[3]  K. Rajewsky,et al.  Shutdown of class switch recombination by deletion of a switch region control element , 1993, Science.

[4]  G. Hertz,et al.  DNA sequences at immunoglobulin switch region recombination sites. , 1993, Nucleic acids research.

[5]  S. Gerondakis,et al.  The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1. , 1993, International immunology.

[6]  C. Snapper,et al.  IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching. , 1993, Journal of immunology.

[7]  T. Maniatis,et al.  Spliced leader RNAs from lower eukaryotes are trans- spliced in mammalian cells , 1992, Nature.

[8]  C. Maliszewski,et al.  Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion , 1992, The Journal of experimental medicine.

[9]  J. Stavnezer,et al.  Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements. , 1992, Journal of immunology.

[10]  Andreas Radbruch,et al.  DNA binding sites 5' of the IgG1 switch region comprising IL4 inducibility and B cell specificity. , 1992, Molecular immunology.

[11]  A. Aguzzi,et al.  Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. , 1992, Genes & development.

[12]  Andreas Radbruch,et al.  Demethylation of the constant region genes of immunoglobulins reflects the differentiation state of the B cell. , 1992, Molecular immunology.

[13]  H. P. Fell,et al.  Cognate interaction between T helper cells and B cells. VII. Role of contact and lymphokines in the expression of germ-line and mature gamma 1 transcripts. , 1992, Journal of Immunology.

[14]  K. Marcu,et al.  Properties of B cell stage specific and ubiquitous nuclear factors binding to immunoglobulin heavy chain gene switch regions. , 1992, International immunology.

[15]  W. Paul,et al.  Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[16]  F. Finkelman,et al.  Ig mu-epsilon isotype switch in IL-4-treated human B lymphoblastoid cells. Evidence for a sequential switch. , 1992, Journal of immunology.

[17]  G. Merkulov,et al.  Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins , 1992, The Journal of experimental medicine.

[18]  M. Wabl,et al.  The murine IgG1/IgE class switch program , 1992, European journal of immunology.

[19]  F. Alt,et al.  T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells. , 1992, Journal of immunology.

[20]  G. Juliusson,et al.  Transcription of unrearranged Ig H chain genes in human B cell malignancies. Biased expression of genes encoded within the first duplication unit of the Ig H chain locus. , 1992, Journal of immunology.

[21]  G. Harriman,et al.  Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation. , 1992, Journal of immunology.

[22]  H. Arakawa,et al.  Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide , 1992, The Journal of experimental medicine.

[23]  E. Clark,et al.  Molecular and biological characterization of a murine ligand for CD40 , 1992, Nature.

[24]  F. Alt,et al.  Function and Control of Recombination‐Activating Gene Activity a , 1992, Annals of the New York Academy of Sciences.

[25]  N. Maizels,et al.  Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[26]  B. Birshtein,et al.  A nuclear DNA-binding protein expressed during early stages of B cell differentiation interacts with diverse segments within and 3' of the Ig H chain gene cluster. , 1992, Journal of immunology.

[27]  C. Snapper,et al.  Induction of IgG3 secretion by interferon gamma: a model for T cell- independent class switching in response to T cell-independent type 2 antigens , 1992, The Journal of experimental medicine.

[28]  J. D. de Vries,et al.  Transforming growth factor-beta directs IgA switching in human B cells. , 1992, Journal of immunology.

[29]  J. Banchereau,et al.  Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A , 1992, The Journal of experimental medicine.

[30]  E. Vitetta,et al.  IL-4-induced expression of germline gamma 1 transcripts in B cells following cognate interactions with T helper cells. , 1992, International immunology.

[31]  P. Tucker,et al.  Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[32]  R. Geha,et al.  Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen , 1992, The Journal of experimental medicine.

[33]  J. Stavnezer,et al.  Regulation of transcription of immunoglobulin germ‐line gamma 1 RNA: analysis of the promoter/enhancer. , 1992, The EMBO journal.

[34]  J. Stavnezer,et al.  Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene. , 1991, Journal of immunology.

[35]  T. Honjo,et al.  Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic mu chain and constant regions of endogenous isotypes. , 1991, International immunology.

[36]  R. Coffman,et al.  Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig. , 1991, Journal of immunology.

[37]  N. Maizels,et al.  LR1, a lipopolysaccharide-responsive factor with binding sites in the immunoglobulin switch regions and heavy-chain enhancer. , 1991, Genes & development.

[38]  K. Rajewsky,et al.  Generation and analysis of interleukin-4 deficient mice. , 1991, Science.

[39]  C. Samakovlis,et al.  Structure of TGF-1-induced human immunoglobulin Ca1 and Ca2 germ-line transcripts , 1991 .

[40]  W. Kerr,et al.  Stage-specific transcription of germline lgH Cγ and Cα regions during human B cell differentiation , 1991 .

[41]  L. Hammarström,et al.  TGF-β1 induces germ-line transcripts of both IgA subclasses in human B lymphocytes , 1991 .

[42]  F. Alt,et al.  Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts , 1991, Molecular and cellular biology.

[43]  M. Lieber.  Site‐specific recombination in the immune system 1 , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[44]  D. Vercelli,et al.  Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. , 1991, Journal of immunology.

[45]  R. Geha,et al.  Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[46]  C. Snapper,et al.  IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4. , 1991, Journal of immunology.

[47]  Akira Shimizu,et al.  Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin. , 1991, International Immunology.

[48]  H. Gascan,et al.  Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. , 1991, Journal of immunology.

[49]  J. Stavnezer.  Triple helix stabilization? , 1991, Nature.

[50]  M. Nussenzweig,et al.  Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene , 1991, The Journal of experimental medicine.

[51]  G. Neale,et al.  mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end. , 1991, Nucleic acids research.

[52]  H. Gascan,et al.  Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones , 1991, The Journal of experimental medicine.

[53]  J. Banchereau,et al.  Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen , 1991, The Journal of experimental medicine.

[54]  R. Noelle,et al.  Cognate interactions between helper T cells and B cells. V. Reconstitution of T helper cell function using purified plasma membranes from activated Th1 and Th2 T helper cells and lymphokines. , 1991, Journal of immunology.

[55]  L. Elenich,et al.  Nuclear protein binding to octamer motifs in the immunoglobulin gamma 1 switch region. , 1991, International immunology.

[56]  R. Rothstein,et al.  Sex, maps, and imprinting , 1991, Cell.

[57]  M. Kagnoff,et al.  Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. , 1990, Journal of immunology.

[58]  R. Geha,et al.  CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells , 1990, The Journal of experimental medicine.

[59]  S. Gerondakis,et al.  RNA splicing generates alternate forms of germline immunoglobulin α heavy chain transcripts , 1990 .

[60]  J. Griffin,et al.  Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region , 1990, Nature.

[61]  H. Sakano,et al.  Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[62]  R. Coffman,et al.  Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. , 1990, Journal of immunology.

[63]  R. Coffman,et al.  Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production , 1990, The Journal of experimental medicine.

[64]  T. Honjo,et al.  Circular DNA is excised by immunoglobulin class switch recombination , 1990, Cell.

[65]  H. Sakano,et al.  Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching , 1990, Cell.

[66]  V. Stewart,et al.  Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching. , 1990, International immunology.

[67]  N. Agabian.  Trans splicing of nuclear pre-mRNAs , 1990, Cell.

[68]  M. Wabl,et al.  Circular DNA is a product of the immunoglobulin class switch rearrangement , 1990, Nature.

[69]  J. Stavnezer,et al.  Induction of germ‐line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination , 1990, European journal of immunology.

[70]  R. Coffman,et al.  Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[71]  M. Kagnoff,et al.  Transforming growth factor-beta 1 is a costimulator for IgA production. , 1990, Journal of immunology.

[72]  A. Barberis,et al.  A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. , 1990, Genes & development.

[73]  A. Kenter,et al.  Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells , 1990, Molecular and cellular biology.

[74]  V. Stewart,et al.  Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon , 1990, Molecular and cellular biology.

[75]  S. Gerondakis,et al.  Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[76]  R. Coffman,et al.  Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures. , 1990, Journal of immunology.

[77]  J. Stavnezer,et al.  Copy choice mechanism of immunoglobulin heavy-chain switch recombination , 1990, Molecular and cellular biology.

[78]  J. Stavnezer,et al.  Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes , 1990, Molecular and cellular biology.

[79]  L. Hood,et al.  Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. , 1990, The EMBO journal.

[80]  T. Manser,et al.  Patterns and extent of isotype-specificity in the murine H chain switch DNA rearrangement. , 1990, Journal of immunology.

[81]  J. Stavnezer,et al.  A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation , 1989, Molecular and cellular biology.

[82]  K. Marcu,et al.  Molecular requirements for immunoglobulin heavy chain constant region gene switch-recombination revealed with switch-substrate retroviruses. , 1989, International immunology.

[83]  P. Sideras,et al.  Production of sterile transcripts of C gamma genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells. , 1989, International immunology.

[84]  Andreas Radbruch,et al.  An interleukin 4-induced DNase I hypersensitive site indicates opening of the gamma 1 switch region prior to switch recombination. , 1989, International immunology.

[85]  P. Leder,et al.  Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[86]  F. Finkelman,et al.  IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[87]  L. Hammarström,et al.  Interleukin 4 induces synthesis of IgE and IgG4 in human B cells , 1989, European journal of immunology.

[88]  M. Walter,et al.  Complete physical map of the human immunoglobulin heavy chain constant region gene complex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[89]  F. Alt,et al.  Molecular characterization of the lymphoid V(D)J recombination activity. , 1989, The Journal of biological chemistry.

[90]  J. Stavnezer,et al.  Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch , 1989, Molecular and cellular biology.

[91]  E. Selsing,et al.  Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[92]  D. Vercelli,et al.  Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens , 1989, The Journal of experimental medicine.

[93]  J. Uhr,et al.  Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[94]  Rodney Rothstein,et al.  Elevated recombination rates in transcriptionally active DNA , 1989, Cell.

[95]  Andreas Radbruch,et al.  Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4. , 1989, The EMBO journal.

[96]  T. Mosmann,et al.  A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. , 1989, Journal of immunology.

[97]  L. Glimcher,et al.  A DNA binding protein regulated by IL-4 and by differentiation in B cells. , 1988, Science.

[98]  R. Reeves,et al.  Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). , 1988, The Journal of biological chemistry.

[99]  F. Alt,et al.  Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells , 1988, The Journal of experimental medicine.

[100]  F. Alt,et al.  Control of Recombination Events During Lymphocyte Differentiation: Heavy Chain Variable Region Gene Assembly and Heavy Chain Class Switching a , 1988, Annals of the New York Academy of Sciences.

[101]  W. Paul,et al.  IL-4 is required to generate and sustain in vivo IgE responses. , 1988, Journal of immunology.

[102]  J. Stavnezer,et al.  Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[103]  R. Coffman,et al.  Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures , 1988, The Journal of experimental medicine.

[104]  K. Arai,et al.  IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[105]  J. Banchereau,et al.  IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. , 1988, Journal of immunology.

[106]  R. Coffman,et al.  Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4. , 1988, Journal of immunology.

[107]  R. Fernandez-Botran,et al.  Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells , 1988, Nature.

[108]  W. Paul,et al.  IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide. , 1988, Journal of immunology.

[109]  C. Heusser,et al.  Interleukin 4 instructs uncommitted B lymphocytes to switch to IgGl and IgE , 1988, European journal of immunology.

[110]  J. Bonnefoy,et al.  Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen , 1988, European journal of immunology.

[111]  F. Alt,et al.  Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching , 1988, Cell.

[112]  R. Coffman,et al.  The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation , 1988, Immunological reviews.

[113]  F. Alt,et al.  Structure and expression of germ line immunoglobulin gamma 2b transcripts , 1988, Molecular and cellular biology.

[114]  W. Paul,et al.  IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide. , 1988, Journal of immunology.

[115]  M. Wabl,et al.  Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[116]  R. Coffman,et al.  IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. , 1988, Journal of immunology.

[117]  W. Paul,et al.  Differential regulation of IgG1 and IgE synthesis by interleukin 4 , 1988, The Journal of experimental medicine.

[118]  M. Cooper,et al.  Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination. , 1987, Journal of immunology.

[119]  U. Krawinkel,et al.  Directed Ig class switch recombination in activated murine B cells. , 1987, The EMBO journal.

[120]  W. Paul,et al.  Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. , 1987, Science.

[121]  F. Alt,et al.  Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre‐B cells. , 1987, The EMBO journal.

[122]  A. Kenter,et al.  Cell cycle kinetics model of LPS-stimulated spleen cells correlates switch region rearrangements with S phase. , 1987, Journal of immunological methods.

[123]  W. Paul,et al.  Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[124]  F. Alt,et al.  Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. , 1986, The EMBO journal.

[125]  J. Uhr,et al.  Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement , 1986, The Journal of experimental medicine.

[126]  R. Coffman,et al.  B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. , 1986, Journal of immunology.

[127]  K. Rajewsky,et al.  Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[128]  R. Coffman,et al.  Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[129]  M. Mowatt,et al.  DNA sequence of the murine gamma 1 switch segment reveals novel structural elements. , 1986, Journal of immunology.

[130]  T. Honjo,et al.  Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter , 1986, Nature.

[131]  R. Coffman,et al.  A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. , 1986, Journal of immunology.

[132]  T. Kipps,et al.  Homologous chromosome recombination generating immunoglobulin allotype and isotype switch variants. , 1986, The EMBO journal.

[133]  Andreas Radbruch,et al.  Control of Immunoglobulin Class Switch Recombination , 1986, Immunological reviews.

[134]  S. Sirlin,et al.  Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. , 1986, The EMBO journal.

[135]  G. Lennon,et al.  Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon , 1985, Nature.

[136]  W. Paul,et al.  Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1 , 1985, The Journal of experimental medicine.

[137]  C. Webb,et al.  Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[138]  P. Krammer,et al.  Activation of the γ1 gene by lipopolysaccharide and T cell-derived lymphokines containing a B cell differentiation factor for IgG1 (BCDFγ) , 1985 .

[139]  B. Birshtein,et al.  Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression , 1985, The Journal of experimental medicine.

[140]  N. Craig.  Site-specific inversion: enhancers, recombination proteins, and mechanism , 1985, Cell.

[141]  J. Petrini,et al.  Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas. , 1985, Journal of immunology.

[142]  M. Wabl,et al.  Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch , 1985, Nature.

[143]  G. Roeder,et al.  Cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae , 1984, Cell.

[144]  J. Uhr,et al.  Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s) , 1984, The Journal of experimental medicine.

[145]  F. Alt,et al.  Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line , 1984, Molecular and cellular biology.

[146]  W. Gilbert,et al.  Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[147]  E. Kabat,et al.  Long identical repeats in the mouse gamma 2b switch region and their implications for the mechanism of class switching. , 1984, EMBO Journal.

[148]  H. Macdonald,et al.  Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines , 1984, Immunological reviews.

[149]  F. Sablitzky,et al.  Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS. , 1983, The EMBO journal.

[150]  T. Honjo,et al.  Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[151]  J. Reiser,et al.  Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells , 1983, Cell.

[152]  G. Morahan,et al.  Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μM exons , 1983, Nature.

[153]  J. Flanagan,et al.  Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes , 1982, Nature.

[154]  D. Katz,et al.  Cloning and nucleotide sequence of mouse immunoglobulin epsilon chain cDNA. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[155]  J. Strathern,et al.  Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus , 1982, Cell.

[156]  L. Stanton,et al.  Nucleotide sequence and properties of the murine γ3 immunoglobulin heavy chain gene switch region: implications for successive Cγ gene switching , 1982 .

[157]  Y. Rosenberg.  Isotype‐Specific T Cell Regulation of Immunoglobulin Expression , 1982, Immunological reviews.

[158]  P. Leder,et al.  A processed human immunoglobulin epsilon gene has moved to chromosome 9. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[159]  C. Fernández,et al.  Characterization of the IgG Response Induced by Polyclonal B Cell Activators , 1982, Immunological reviews.

[160]  T. Miyata,et al.  The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence. , 1982, The EMBO journal.

[161]  T. Honjo,et al.  Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. , 1982, The Journal of biological chemistry.

[162]  L. Stanton,et al.  A model for the molecular requirements of immunoglobulin heavy chain class switching , 1982, Nature.

[163]  T. Honjo,et al.  Structure of human immunoglobulin gamma genes: implications for evolution of a gene family , 1982, Cell.

[164]  F. Blattner,et al.  Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[165]  P. Leder,et al.  Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. , 1982, Science.

[166]  T. Honjo,et al.  Organization of the constant-region gene family of the mouse immunoglobulin heavy chain , 1982, Cell.

[167]  Ellen S. Vitetta,et al.  T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells , 1982, The Journal of experimental medicine.

[168]  F. Blattner,et al.  Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[169]  A. Kenter,et al.  Chi, a promoter of generalized recombination in λ phage, is present in immunoglobulin genes , 1981, Nature.

[170]  T. Honjo,et al.  Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences , 1981, Nature.

[171]  S. Kunes,et al.  Structure of chi hotspots of generalized recombination , 1981, Cell.

[172]  S. Tonegawa,et al.  The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes , 1981, Cell.

[173]  T. Honjo,et al.  Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[174]  T. Miyata,et al.  Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes , 1981, Cell.

[175]  W. Paul,et al.  T cell regulation of IgG subclass antibody production in response to T- independent antigens , 1981, The Journal of experimental medicine.

[176]  F. Blattner,et al.  Mouse immunoglobulin D: messenger RNA and genomic DNA sequences. , 1980, Science.

[177]  Mark M. Davis,et al.  DNA sequences mediating class switching in alpha-immunoglobulins. , 1980, Science.

[178]  T. Honjo,et al.  Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. , 1980, Nucleic acids research.

[179]  Hitoshi Sakano,et al.  Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes , 1980, Nature.

[180]  David Baltimore,et al.  Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends , 1980, Cell.

[181]  J. Rogers,et al.  Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain , 1980, Cell.

[182]  K. Rajewsky,et al.  Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[183]  R. Perry,et al.  Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[184]  F. Blattner,et al.  Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA. , 1979, Science.

[185]  E. Gronowicz,et al.  Cell differentiation in the presence of cytochalasin B: studies on the "switch" to IgG secretion after polyclonal B cell activation. , 1979, Journal of Immunology.

[186]  S. Tonegawa,et al.  Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments , 1979, Nature.

[187]  S. Pierce,et al.  Individual antigen-specific T lymphocytes: helper function in enabling the expression of multiple antibody isotypes , 1978, The Journal of experimental medicine.

[188]  J. Kearney,et al.  Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversity. , 1978, Journal of immunology.

[189]  A. Coutinho,et al.  Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti‐immunoglobulin antibodies , 1978, European journal of immunology.

[190]  R. Coffman,et al.  The class of surface immunoglobulin on virgin and memory B lymphocytes. , 1977, Journal of immunology.

[191]  J. Kearney,et al.  B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies. , 1976, Journal of immunology.

[192]  S. Pierce,et al.  The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses , 1975, The Journal of experimental medicine.

[193]  J. Schrader.  The role of T cells in IgG production; thymus-dependent antigens induce B cell memory in the absence of T cells. , 1975, Journal of immunology.

[194]  N H Sigal,et al.  Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[195]  D. D. Manning.  Recovery from anti-IG induced immunosuppression: implications for a model of Ig-secreting cell development. , 1974, Journal of Immunology.

[196]  N. Klinman,et al.  MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY , 1973, The Journal of experimental medicine.

[197]  T. Tomasi,et al.  PRODUCTION OF A RUNTING SYNDROME AND SELECTIVE γA DEFICIENCY IN MICE BY THE ADMINISTRATION OF ANTI-HEAVY CHAIN ANTISERA , 1973, The Journal of experimental medicine.

[198]  F. Grumet,et al.  GENETIC CONTROL OF THE IMMUNE RESPONSE , 1972, American journal of clinical pathology.

[199]  H. Mcdevitt,et al.  GENETIC CONTROL OF THE IMMUNE RESPONSE , 1972, The Journal of experimental medicine.

[200]  A. Nisonoff,et al.  Evidence for control of synthesis of the varible regions of the heavy chains of immunoglobulins G and M by the same gene. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[201]  J. Oudin,et al.  IDIOTYPY OF RABBIT ANTIBODIES , 1969, The Journal of experimental medicine.

[202]  B. Benacerraf,et al.  IMMUNE RESPONSES IN VITRO , 1969, The Journal of experimental medicine.

[203]  G. Nossal,et al.  SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION , 1964, The Journal of experimental medicine.

[204]  D. C. Bauer,et al.  SEQUENCES OF SYNTHESIS OF γ-1 MACROGLOBULIN AND γ-2 GLOBULIN ANTIBODIES DURING PRIMARY AND SECONDARY RESPONSES TO PROTEINS, SALMONELLA ANTIGENS, AND PHAGE , 1963, The Journal of experimental medicine.

[205]  Jonathan W. Uhr,et al.  ANTIBODY FORMATION , 1963, The Journal of experimental medicine.

[206]  D. Parker.  T cell-dependent B cell activation. , 1993, Annual review of immunology.

[207]  園田 英一朗.  Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production , 1992 .

[208]  A. Whitmore,et al.  Ig isotype switching in B lymphocytes. The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma. , 1991, International immunology.

[209]  R. Coffman,et al.  Lymphokine control of in vivo immunoglobulin isotype selection. , 1990, Annual review of immunology.

[210]  F. Mills,et al.  Sequences of human immunoglobulin switch regions: implications for recombination and transcription. , 1990, Nucleic acids research.

[211]  J. Stavnezer,et al.  Structure of Germline Immunoglobulin Heavy-Chain γ1 Transcripts in Interleukin 4 Treated Mouse Spleen Cells , 1990, Developmental immunology.

[212]  F. Alt,et al.  Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. , 1989, Annual review of genetics.

[213]  Gritzmacher Ca.  Molecular aspects of heavy-chain class switching. , 1989 .

[214]  A. A. Brian,et al.  Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[215]  S. Cory.  Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. , 1986, Advances in cancer research.

[216]  F. Finkelman,et al.  B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA/9 mice do not provide evidence for isotype switching without gene deletion. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[217]  P. Sideras,et al.  Partial biochemical characterization of IgG1‐inducing factor , 1985, European journal of immunology.

[218]  J. Kearney,et al.  Studies of generation of B-cell diversity in mouse, man, and chicken. , 1977, Cold Spring Harbor symposia on quantitative biology.

[219]  L. Forni,et al.  Synthesis of multiple immunoglobulin classes by single lymphocytes. , 1977, Cold Spring Harbor symposia on quantitative biology.

[220]  K. Ishizaka.  Cellular events in the IgE antibody response. , 1976, Advances in immunology.

[221]  M. Cooper,et al.  Modification of B lymphocyte differentiation by anti-immunoglobulins. , 1974, Contemporary topics in immunobiology.

[222]  M. Cooper,et al.  A Developmental Approach to the Biological Basis for Antibody Diversity , 1972 .

[223]  R. Coffman,et al.  Brief Definitive Report TRANSFORMING GROWTH FACTOR # SPECIFICALLY ENHANCES IgA PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED , 2022 .

[224]  E. Vitetta,et al.  Materials and Methods Brief Definitive Report Interleukin 4 Induces Changes in the Chromatin Structure of the Yl Switch Region in Resting B Cells before Switch Recombination , 2022 .