Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper Endoscopy

Background:  Peptic ulcers and erosions (PU&E) are thought to be uncommon in children. Patients with early exposure to Helicobacter pylori may be at a higher risk for early onset PU&E. Children in Israel have a high prevalence and early acquisition of Helicobacter pylori (H. pylori) and have easy access to pediatric gastroenterologists and endoscopy. Our aim was to describe the prevalence and characteristics of PU&E in this population referred by Pediatric Gastroenterologists for an upper endoscopy.

[1]  M. Goske.  Gastritis, Gastropathy, and Ulcer Disease , 2008 .

[2]  R. Eliakim,et al.  Wireless Video Capsule in Pediatric Patients With Functional Abdominal Pain , 2007, Journal of pediatric gastroenterology and nutrition.

[3]  S. Bar‐Meir.  Review article: capsule endoscopy – are all small intestinal lesions Crohn's disease? , 2006, Alimentary pharmacology & therapeutics.

[4]  E. Hassall,et al.  Chapter 25 – Gastritis, gastropathy and ulcer disease , 2006 .

[5]  K. McColl,et al.  Gastroduodenal disease, Helicobacter pylori, and genetic polymorphisms. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[6]  D. Graham,et al.  Atrophic gastritis in young children and adolescents , 2005, Journal of Clinical Pathology.

[7]  M. E. El Mouzan,et al.  Peptic ulcer disease in children and adolescents. , 2004, Journal of tropical pediatrics.

[8]  R. Eliakim,et al.  Comparison of Invasive and Non-Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children , 2004, Journal of pediatric gastroenterology and nutrition.

[9]  J. Kleibeuker,et al.  Does the declining prevalence of Helicobacter pylori unmask patients with idiopathic peptic ulcer disease? Trends over an 8 year period , 2004, European journal of gastroenterology & hepatology.

[10]  Y. Nishino,et al.  The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease , 2004, Journal of Gastroenterology.

[11]  T. Miloh,et al.  Validation of a novel real time 13C urea breath test for rapid evaluation of Helicobacter pylori in children and adolescents. , 2004, The Journal of pediatrics.

[12]  J. Gisbert,et al.  The Prevalence of Peptic Ulcer not Related to Helicobacter pylori or Non‐Steroidal Anti‐Inflammatory Drug Use is Negligible in Southern Europe , 2004, Helicobacter.

[13]  J. Freston,et al.  Attributable Risk of H. pylori in Peptic Ulcer Disease , 2001, Digestive Diseases and Sciences.

[14]  M. Boaz,et al.  Influence of Helicobacter pylori eradication on gastroesophageal reflux symptoms and epigastric pain in children and adolescents. , 2004, Pediatrics.

[15]  Y. Niv,et al.  13C-Urea Breath Test, Referral Patterns, and Results in Children , 2003, Journal of clinical gastroenterology.

[16]  M. Tannemaat,et al.  Serologic Prevalence of Antibodies to Helicobacter pylori in Internationally Adopted Children , 2003, Helicobacter.

[17]  E. Hassall.  Getting to Grips With Gastric Pathology , 2002, Journal of pediatric gastroenterology and nutrition.

[18]  H. Demir,et al.  Peptic Ulcer Disease in Children Without Helicobacter pylori Infection , 2002, Helicobacter.

[19]  C. O'Morain,et al.  Helicobacter pylori Infection , 1994 .

[20]  N. Talley,et al.  Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs , 2002, American Journal of Gastroenterology.

[21]  W. Wong,et al.  Clinical and endoscopic characteristics of non‐Helicobacter pylori, non‐NSAID duodenal ulcers: a long‐term prospective study , 2001, Alimentary pharmacology & therapeutics.

[22]  P. Sherman,et al.  Approaching Helicobacter pylori infection in children: level I evidence at last and a word of caution. , 2001, The Journal of pediatrics.

[23]  V. Vakhitov,et al.  Childhood Peptic Ulcer in the Ural Area of Russia: Clinical Status and Helicobacter pylori–Associated Immune Response , 2001, Journal of pediatric gastroenterology and nutrition.

[24]  Y. Elitsur,et al.  Non‐Helicobacter pylori Related Duodenal Ulcer Disease in Children , 2001, Helicobacter.

[25]  E. Roma,et al.  Is peptic ulcer a common cause of upper gastrointestinal symptoms? , 2001, European Journal of Pediatrics.

[26]  W. Avenhaus,et al.  Helicobacter pylori-negative gastric ulcerations associated with celiac disease at first presentation. , 2001, Zeitschrift fur Gastroenterologie.

[27]  G. Rennert,et al.  Prevalence of selected chronic diseases in Israel. , 2001, The Israel Medical Association journal : IMAJ.

[28]  M. Feldman,et al.  Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial , 2001, American Journal of Gastroenterology.

[29]  D. Graham,et al.  Geographic differences in the distribution of intestinal metaplasia in duodenal ulcer patients , 2001, American Journal of Gastroenterology.

[30]  B. Drumm,et al.  Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? , 2001, Pediatrics.

[31]  N. Talley,et al.  Demographic and endoscopic characteristics of patients with Helicobacter pylori positive and negative peptic ulcer disease , 2000, The Medical journal of Australia.

[32]  M. Stringer,et al.  Gastroduodenal ulcers in the Helicobacter pyloriera , 2000, Acta paediatrica.

[33]  B. Gold,et al.  Helicobacter pylori infection in children: To test or not test...what is the eviedence? , 2000 .

[34]  D. Peura.  The problem of Helicobacter pylori-negative idiopathic ulcer disease. , 2000, Bailliere's best practice & research. Clinical gastroenterology.

[35]  M. Kasuga,et al.  Helicobacter pylori-negative peptic ulcer in Japan: which contributes most to peptic ulcer development, Helicobacter pylori, NSAIDS or stress? , 2000, Journal of gastroenterology.

[36]  B. Gold,et al.  Helicobacter pylori infection in children: to test or not to test...what is the evidence? , 2000, The Journal of pediatrics.

[37]  E. Hassall,et al.  Gastritis and gastropathy of childhood. , 1999, Journal of pediatric gastroenterology and nutrition.

[38]  K. Tominaga,et al.  Is Helicobacter pylori-Negative Duodenal Ulcer Masked by the High Prevalence of H. pylori Infection in the General Population? , 1999, American Journal of Gastroenterology.

[39]  M. Minami,et al.  Helicobacter pylori-negative gastric and duodenal ulcers , 1999, Journal of Gastroenterology.

[40]  J. Palmer,et al.  Helicobacter pylori infection rates in duodenal ulcer patients in the United States may be lower than previously estimated , 1999, American Journal of Gastroenterology.

[41]  R. Batey,et al.  Low prevalence of Helicobacter pylori in an Australian duodenal ulcer population: NSAIDitis or the effect of ten years of H. pylori treatment? , 1998, Australian and New Zealand journal of medicine.

[42]  R. Gascoyne,et al.  Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. , 1997, Journal of clinical gastroenterology.

[43]  L. Neumann,et al.  Demographic data from a hospital case series of endoscopically-diagnosed benign peptic ulcer in southern Israel, 1989-1990. , 1995, Public health reviews.

[44]  M. Glassman,et al.  Peptic ulcer disease in children. , 1994, Gastrointestinal endoscopy clinics of North America.

[45]  G. Daskalopoulos,et al.  Helicobacter pylori Infection in Children: Potential Clues to Pathogenesis , 1993, Journal of pediatric gastroenterology and nutrition.

[46]  E. Hassall,et al.  Unique features of Helicobacter pylori disease in children. , 1992, Digestive diseases and sciences.

[47]  W. R. Zhang,et al.  Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying. , 1991, Life sciences.

[48]  A. Wald,et al.  Celiac sprue complicated by lymphoma presenting with multiple gastric ulcers. , 1986, Gastroenterology.

[49]  V. Tolia,et al.  Peptic Ulcer Disease in Children and Adolescents , 1983, Clinical pediatrics.