Merging Worlds of Nanomaterials and Biological Environment: Factors Governing Protein Corona Formation on Nanoparticles and Its Biological Consequences

Protein corona has became a prevalent subject in the field of nanomedicine owing to its diverse role in determining the efficiency, efficacy, and the ultimate biological fate of the nanomaterials used as a tool to treat and diagnose various diseases. For instance, protein corona formation on the surface of nanoparticles can modify its physicochemical properties and interfere with its intended functionalities in the biological microenvironments. As such, much emphasis should be placed in understanding these complex phenomena that occur at the bio-nano interface. The main aim of this review is to present different factors that are influencing protein-nanoparticle interaction such as physicochemical properties of nanoparticle (i.e., size and size distribution, shape, composition, surface chemistry, and coatings) and the effect of biological microenvironments. Apart from that, the effect of ignored factors at the bio-nano interface such as temperature, plasma concentration, plasma gradient effect, administration route, and cell observer were also addressed.

[1]  S. Nie,et al.  Therapeutic Nanoparticles for Drug Delivery in Cancer Types of Nanoparticles Used as Drug Delivery Systems , 2022 .

[2]  Morteza Mahmoudi,et al.  Protein-Nanoparticle Interactions , 2013 .

[3]  M. Sahraian,et al.  Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of multiple sclerosis. , 2011, ACS chemical neuroscience.

[4]  M. Mahmoudi,et al.  Significance of cell "observer" and protein source in nanobiosciences. , 2013, Journal of colloid and interface science.

[5]  R. Müller,et al.  Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting. , 2005, International journal of pharmaceutics.

[6]  Andrew Emili,et al.  Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. , 2014, ACS nano.

[7]  Craig H Meyer,et al.  Technology Insight: in vivo cell tracking by use of MRI , 2006, Nature Clinical Practice Cardiovascular Medicine.

[8]  Sean Callanan,et al.  Internal benchmarking of a human blood-brain barrier cell model for screening of nanoparticle uptake and transcytosis. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[9]  Chad A Mirkin,et al.  The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles. , 2009, ACS nano.

[10]  Horst Weller,et al.  Quantized Semiconductor Particles: A novel state of matter for materials science , 1993 .

[11]  R. Müller,et al.  Nanoparticles with decreasing surface hydrophobicities: influence on plasma protein adsorption. , 2000, International journal of pharmaceutics.

[12]  James E Bear,et al.  PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. , 2012, Nano letters.

[13]  Darren J. Martin,et al.  Differential plasma protein binding to metal oxide nanoparticles , 2009, Nanotechnology.

[14]  Kenneth A Dawson,et al.  Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency. , 2013, Journal of the American Chemical Society.

[15]  T. Xia,et al.  Understanding biophysicochemical interactions at the nano-bio interface. , 2009, Nature materials.

[16]  Michael M. Gottesman,et al.  Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis , 2010, Proceedings of the National Academy of Sciences.

[17]  C. Wiener.  Harrison's principles of internal medicine , 2013 .

[18]  Marco P Monopoli,et al.  Biomolecular coronas provide the biological identity of nanosized materials. , 2012, Nature nanotechnology.

[19]  Y. Wang.  Nonlinear optical properties of nanometer-sized semiconductor clusters , 1991 .

[20]  V. Kolb-Bachofen,et al.  Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. , 1993, Biochimica et biophysica acta.

[21]  I. Singh,et al.  Fever and the heat shock response: distinct, partially overlapping processes , 2000, Cell stress & chaperones.

[22]  R. Müller,et al.  Adsorption kinetics of plasma proteins on ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. , 2012, International journal of pharmaceutics.

[23]  P. Sadler,et al.  Identification of platination sites on human serum transferrin using 13C and 15N NMR spectroscopy , 1999, JBIC Journal of Biological Inorganic Chemistry.

[24]  Xing-jie Liang,et al.  Interaction of stable colloidal nanoparticles with cellular membranes. , 2014, Biotechnology advances.

[25]  Shaojun Dong,et al.  pH-dependent protein conformational changes in albumin:gold nanoparticle bioconjugates: a spectroscopic study. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[26]  Jack F Douglas,et al.  Interaction of gold nanoparticles with common human blood proteins. , 2010, ACS nano.

[27]  Liwei Lin,et al.  Quantum dot nano thermometers reveal heterogeneous local thermogenesis in living cells. , 2011, ACS nano.

[28]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[29]  J. Karp,et al.  Nanoparticle-based monitoring of cell therapy , 2011, Nanotechnology.

[30]  Iseult Lynch,et al.  What the cell "sees" in bionanoscience. , 2010, Journal of the American Chemical Society.

[31]  Jonathan S Dordick,et al.  Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[32]  Morteza Mahmoudi,et al.  Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles. , 2011, Nanoscale.

[33]  G. Nienhaus,et al.  Toward a molecular understanding of nanoparticle–protein interactions , 2012, Biophysical Reviews.

[34]  Chad A. Mirkin,et al.  Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation , 2006, Science.

[35]  Raimo Hartmann,et al.  Temperature: the "ignored" factor at the NanoBio interface. , 2013, ACS nano.

[36]  Sara Linse,et al.  Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles , 2007, Proceedings of the National Academy of Sciences.

[37]  M. Mahmoudi,et al.  Protein-nanoparticle interactions: opportunities and challenges. , 2011, Chemical reviews.

[38]  S. K. Sundaram,et al.  Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials. , 2007, Toxicological sciences : an official journal of the Society of Toxicology.

[39]  R. Mann,et al.  Human Physiology , 1839, Nature.

[40]  R. Müller,et al.  Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns , 2005, Journal of drug targeting.

[41]  Korin E. Wheeler,et al.  Silver nanoparticle protein corona composition compared across engineered particle properties and environmentally relevant reaction conditions , 2014 .

[42]  Louis E. Brus,et al.  Semiconductor crystallites: a class of large molecules , 1990 .

[43]  Albert Duschl,et al.  Time evolution of the nanoparticle protein corona. , 2010, ACS nano.

[44]  Urs O. Häfeli,et al.  Crucial Ignored Parameters on Nanotoxicology: The Importance of Toxicity Assay Modifications and “Cell Vision” , 2012, PloS one.

[45]  L. Vroman,et al.  Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces. , 1980, Blood.

[46]  J. Bigby.  Harrison's Principles of Internal Medicine , 1988 .

[47]  Iseult Lynch,et al.  Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. , 2011, Journal of the American Chemical Society.

[48]  Morteza Mahmoudi,et al.  Nanoparticle and Protein Corona , 2013 .

[49]  Kenneth A. Dawson,et al.  Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells. , 2012, ACS nano.

[50]  Stefan Tenzer,et al.  Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis. , 2011, ACS nano.

[51]  James L. McGrath,et al.  The influence of protein adsorption on nanoparticle association with cultured endothelial cells. , 2009, Biomaterials.

[52]  Jinwoo Cheon,et al.  Exchange-coupled magnetic nanoparticles for efficient heat induction. , 2011, Nature nanotechnology.

[53]  Andrew Emili,et al.  Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles. , 2014, ACS nano.

[54]  Feng Zhao,et al.  Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes. , 2011, Nanoscale.

[55]  Warren C W Chan,et al.  Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. , 2012, Chemical Society reviews.

[56]  Morteza Mahmoudi,et al.  A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. , 2010, Colloids and surfaces. B, Biointerfaces.

[57]  L. Treuel.  How Protein Adsorption Shapes the Biological Identity of NPs - Where do we Stand? , 2013 .

[58]  R. Müller,et al.  Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[59]  A. Ditto,et al.  Non-viral gene delivery using nanoparticles , 2009, Expert opinion on drug delivery.

[60]  Iseult Lynch,et al.  The evolution of the protein corona around nanoparticles: a test study. , 2011, ACS nano.

[61]  Kenneth A. Dawson,et al.  Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts , 2008, Proceedings of the National Academy of Sciences.

[62]  Parag Aggarwal,et al.  Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles. , 2009, Nanomedicine : nanotechnology, biology, and medicine.

[63]  M. Mahmoudi,et al.  Plasma concentration gradient influences the protein corona decoration on nanoparticles , 2013 .

[64]  Albert Duschl,et al.  Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle , 2013, Journal of Nanobiotechnology.

[65]  C. Brennan,et al.  A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle , 2011, Nature Medicine.

[66]  Morteza Mahmoudi,et al.  Variation of protein corona composition of gold nanoparticles following plasmonic heating. , 2014, Nano letters.

[67]  Roberto Cingolani,et al.  Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response. , 2010, ACS nano.

[68]  David Farrar,et al.  Interpretation of protein adsorption: surface-induced conformational changes. , 2005, Journal of the American Chemical Society.

[69]  Sara Linse,et al.  Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. , 2007, Angewandte Chemie.

[70]  R. Müller,et al.  Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral nutrition. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[71]  C. Costa Vera,et al.  Conformational stability of adsorbed insulin studied with mass spectrometry and hydrogen exchange. , 1999, Analytical chemistry.

[72]  Walter Kolch,et al.  Big signals from small particles: regulation of cell signaling pathways by nanoparticles. , 2013, Chemical reviews.

[73]  K. Higaki,et al.  Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics. , 2007, International journal of pharmaceutics.

[74]  Mauro Ferrari,et al.  Sustained small interfering RNA delivery by mesoporous silicon particles. , 2010, Cancer research.

[75]  M. Mahmoudi,et al.  Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. , 2011, Advanced drug delivery reviews.

[76]  Parag Aggarwal,et al.  Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. , 2009, Advanced drug delivery reviews.

[77]  Ji-Ho Park,et al.  Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. , 2009, Biomaterials.

[78]  R. Müller,et al.  'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. , 2000, Colloids and surfaces. B, Biointerfaces.