The influence of menopause and body mass index on serum leptin concentrations.

OBJECTIVE The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI <25 kg/m(2) (n=137), (b) premenopausal women BMI >25 kg/m(2) (n=81), (c) postmenopausal women BMI <25 kg/m(2) (n=94) and (d) postmenopausal women BMI >25 kg/m(2) (n=122). RESULTS Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI <25 kg/m(2) (P<0.001). The multiple linear regression analyses showed that BMI was the only statistically significant independent predictor for leptin. In comparison to postmenopausal women, premenopausal women showed a significantly lower mean age, weight, BMI and FSH concentration (P<0. 001), a higher mean height and serum estradiol (P<0.01 and P<0.001 respectively) but significantly lower serum leptin concentration (P<0.01). The multiple linear regression model showed no significant influence of menopausal status or serum estradiol on serum leptin concentration, even after controlling for BMI. CONCLUSIONS Serum leptin concentrations are significantly higher in pre- and postmenopausal obese women, compared with normal weight controls. Serum leptin concentrations are not influenced by menopausal status or serum estradiol level.

[1]  M. Saad,et al.  Changes in plasma leptin during the menstrual cycle. , 1998, European journal of endocrinology.

[2]  R. Huupponen,et al.  Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women. , 1998, European journal of endocrinology.

[3]  G. Paolisso,et al.  Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects , 1998, Clinical endocrinology.

[4]  S. Haffner,et al.  Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy. , 1997, American journal of epidemiology.

[5]  N. Sato,et al.  Estrogen increases in vivo leptin production in rats and human subjects. , 1997, The Journal of endocrinology.

[6]  M. Uusitupa,et al.  Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. , 1997, European journal of endocrinology.

[7]  P. Trayhurn,et al.  Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy , 1997, Clinical endocrinology.

[8]  B. Jeanrenaud,et al.  The discovery of leptin and its impact in the understanding of obesity. , 1996, European journal of endocrinology.

[9]  S. Klein,et al.  Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. , 1996, The Journal of clinical endocrinology and metabolism.

[10]  H. Yki-Järvinen,et al.  Supraphysiological Hyperinsulinemia Increases Plasma Leptin Concentrations After 4 h in Normal Subjects , 1996, Diabetes.

[11]  C. Christoffersen,et al.  Insulin and Cortisol Promote Leptin Production in Cultured Human Fat Cells , 1996, Diabetes.

[12]  J. Ohannesian,et al.  Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. , 1996, The Journal of clinical investigation.

[13]  R. Leibel,et al.  Effects of gender, body composition, and menopause on plasma concentrations of leptin. , 1996, The Journal of clinical endocrinology and metabolism.

[14]  C. Mantzoros,et al.  Role of leptin in the neuroendocrine response to fasting , 1996, Nature.

[15]  S. Klein,et al.  Relationship Between Insulin Sensitivity and Plasma Leptin Concentration in Lean and Obese Men , 1996, Diabetes.

[16]  Hongping,et al.  Leptin is a metabolic signal to the reproductive system. , 1996, Endocrinology.

[17]  S. Mudaliar,et al.  Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro , 1996, Diabetes.

[18]  C. Björkelund,et al.  Reproductive history in relation to relative weight and fat distribution. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[19]  R. Considine,et al.  Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.

[20]  E. Ravussin,et al.  Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects , 1995, Nature Medicine.

[21]  F. Lönnqvist,et al.  Overexpression of the obese (ob) gene in adipose tissue of human obese subjects , 1995, Nature Medicine.

[22]  R. Devos,et al.  Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.

[23]  Steven L. Cohen,et al.  Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.

[24]  M. Pelleymounter,et al.  Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.

[25]  K. Nakao,et al.  Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue , 1995, Diabetes.

[26]  R. Pasquali,et al.  Body weight, fat distribution and the menopausal status in women. The VMH Collaborative Group. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[27]  C. Christiansen,et al.  Estrogen/gestagen therapy changes soft tissue body composition in postmenopausal women. , 1989, Metabolism: clinical and experimental.

[28]  R. Hoffmann,et al.  Adiposity, fat distribution, and cardiovascular risk. , 1989, Annals of internal medicine.

[29]  R. Hoffmann,et al.  Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. , 1983, The Journal of clinical endocrinology and metabolism.

[30]  M. Hickey,et al.  GENDER DIFFERENCES IN PLASMA LEPTIN CONCENTRATION ARE NOT INFLUENCED BY MENOPAUSE OR HORMONE REPLACEMENT THERAPY , 1998 .

[31]  A. Goldberg,et al.  Racial differences in plasma leptin concentrations in obese postmenopausal women. , 1997, Journal of Clinical Endocrinology and Metabolism.

[32]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[33]  C. Bengtsson,et al.  Serum lipids, arterial blood pressure and body weight in relation to the menopause: results from a population study of women in Göteborg, Sweden. , 1980, Scandinavian journal of clinical and laboratory investigation.