Genetic association studies of complex traits: design and analysis issues.

[1]  Frank Dudbridge,et al.  Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. , 2004, American journal of human genetics.

[2]  J. She,et al.  A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes , 2004, Nature Genetics.

[3]  M. Daly,et al.  Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. , 2004, American journal of human genetics.

[4]  P. Donnelly,et al.  The effects of human population structure on large genetic association studies , 2004, Nature Genetics.

[5]  M. Daly,et al.  Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. , 2004, Diabetes.

[6]  S. Gabriel,et al.  Assessing the impact of population stratification on genetic association studies , 2004, Nature Genetics.

[7]  Nathaniel Rothman,et al.  Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies , 2004 .

[8]  Jing Huang,et al.  Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. , 2004, Genome research.

[9]  Toshihiro Tanaka.  The International HapMap Project , 2003, Nature.

[10]  R. Ward,et al.  Informativeness of genetic markers for inference of ancestry. , 2003, American journal of human genetics.

[11]  D. Altshuler,et al.  The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. , 2003, Annual review of genomics and human genetics.

[12]  J. Manson,et al.  Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. , 2003, Human molecular genetics.

[13]  E. Tai,et al.  Dietary fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. , 2003, The Journal of nutrition.

[14]  Juliet M Chapman,et al.  Detecting Disease Associations due to Linkage Disequilibrium Using Haplotype Tags: A Class of Tests and the Determinants of Statistical Power , 2003, Human Heredity.

[15]  Jeremy Heil,et al.  A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. , 2003, American journal of human genetics.

[16]  M. Daly,et al.  IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. , 2003, American journal of human genetics.

[17]  Luc J. Smink,et al.  Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease , 2003, Nature.

[18]  F. Collins,et al.  The Human Genome Project: Lessons from Large-Scale Biology , 2003, Science.

[19]  L. Cardon,et al.  Analysis of the IBD5 locus and potential gene-gene interactions in Crohn’s disease , 2003, Gut.

[20]  S. Fisher,et al.  Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. , 2003, American journal of human genetics.

[21]  Aravinda Chakravarti,et al.  Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. , 2003, American journal of human genetics.

[22]  D. Botstein,et al.  Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease , 2003, Nature Genetics.

[23]  L. Pérusse,et al.  The PPAR‐gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study , 2003, Clinical genetics.

[24]  E. Lander,et al.  Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease , 2003, Nature Genetics.

[25]  N. O’Callaghan,et al.  CARD15/NOD2 Risk Alleles in the Development of Crohn's Disease in the Australian Population , 2003, Annals of human genetics.

[26]  Kari Stefansson,et al.  Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. , 2003, American journal of human genetics.

[27]  Terrence S. Furey,et al.  The UCSC Genome Browser Database , 2003, Nucleic Acids Res..

[28]  L. Peltonen,et al.  Classical twin studies and beyond , 2002, Nature Reviews Genetics.

[29]  P. Wilson,et al.  Dietary Fat Intake Determines the Effect of a Common Polymorphism in the Hepatic Lipase Gene Promoter on High-Density Lipoprotein Metabolism: Evidence of a Strong Dose Effect in This Gene-Nutrient Interaction in the Framingham Study , 2002, Circulation.

[30]  David Altshuler,et al.  Once and again-issues surrounding replication in genetic association studies. , 2002, The Journal of clinical endocrinology and metabolism.

[31]  H. Stefánsson,et al.  Neuregulin 1 and susceptibility to schizophrenia. , 2002, American journal of human genetics.

[32]  K. Lunetta,et al.  Testing for population subdivision and association in four case-control studies. , 2002, American journal of human genetics.

[33]  M. Daly,et al.  CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. , 2002, American journal of human genetics.

[34]  D. Gudbjartsson,et al.  A high-resolution recombination map of the human genome , 2002, Nature Genetics.

[35]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[36]  S. Gabriel,et al.  The Structure of Haplotype Blocks in the Human Genome , 2002, Science.

[37]  R. Myers,et al.  Candidate-gene approaches for studying complex genetic traits: practical considerations , 2002, Nature Reviews Genetics.

[38]  L. Kruglyak,et al.  Patterns of linkage disequilibrium in the human genome , 2002, Nature Reviews Genetics.

[39]  J. Hirschhorn,et al.  A comprehensive review of genetic association studies , 2002, Genetics in Medicine.

[40]  P. Sklar.  Linkage analysis in psychiatric disorders: the emerging picture. , 2002, Annual review of genomics and human genetics.

[41]  S. P. Fodor,et al.  Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21 , 2001, Science.

[42]  L. Palmer,et al.  Genomewide scans of complex human diseases: true linkage is hard to find. , 2001, American journal of human genetics.

[43]  J. Ioannidis,et al.  Replication validity of genetic association studies , 2001, Nature Genetics.

[44]  Frank Dudbridge,et al.  Haplotype tagging for the identification of common disease genes , 2001, Nature Genetics.

[45]  Sinead B. O'Leary,et al.  Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease , 2001, Nature Genetics.

[46]  N J Cox,et al.  Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. , 2001, American journal of human genetics.

[47]  Justin C. Fay,et al.  Positive and negative selection on the human genome. , 2001, Genetics.

[48]  S. Fisher,et al.  Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations , 2001, The Lancet.

[49]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[50]  Judy H. Cho,et al.  A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease , 2001, Nature.

[51]  D. Nickerson,et al.  Variation is the spice of life , 2001, Nature Genetics.

[52]  Timothy B. Stockwell,et al.  The Sequence of the Human Genome , 2001, Science.

[53]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[54]  L. Cardon,et al.  Association study designs for complex diseases , 2001, Nature Reviews Genetics.

[55]  L. Pennacchio,et al.  Genomic strategies to identify mammalian regulatory sequences , 2001, Nature Reviews Genetics.

[56]  D. Reich,et al.  Detecting association in a case‐control study while correcting for population stratification , 2001, Genetic epidemiology.

[57]  M. Redondo,et al.  Genetics of type 1A diabetes. , 2001, Recent progress in hormone research.

[58]  Anita L. DeStefano,et al.  Evidence for a Gene Influencing Blood Pressure on Chromosome 17: Genome Scan Linkage Results for Longitudinal Blood Pressure Phenotypes in Subjects From the Framingham Heart Study , 2000, Hypertension.

[59]  Eric S. Lander,et al.  An SNP map of the human genome generated by reduced representation shotgun sequencing , 2000, Nature.

[60]  P. Sham,et al.  Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. , 2000, American journal of human genetics.

[61]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[62]  J. Pritchard,et al.  Use of unlinked genetic markers to detect population stratification in association studies. , 1999, American journal of human genetics.

[63]  N E Morton,et al.  Tests and estimates of allelic association in complex inheritance. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[64]  J C Murray,et al.  Pediatrics and , 1998 .

[65]  M. Boehnke,et al.  Genetic association mapping based on discordant sib pairs: the discordant-alleles test. , 1998, American journal of human genetics.

[66]  W. Ewens,et al.  A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. , 1998, American journal of human genetics.

[67]  D. Allison,et al.  Transmission-disequilibrium tests for quantitative traits. , 1997, American journal of human genetics.

[68]  W J Ewens,et al.  The TDT and other family-based tests for linkage disequilibrium and association. , 1996, American journal of human genetics.

[69]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[70]  Cécile Fizames,et al.  A comprehensive genetic map of the human genome based on 5,264 microsatellites , 1996, Nature.

[71]  J. Todd,et al.  Human type 1 diabetes and the insulin gene: principles of mapping polygenes. , 1996, Annual review of genetics.

[72]  R. Doerge,et al.  Permutation tests for multiple loci affecting a quantitative character. , 1996, Genetics.

[73]  D Curtis,et al.  A note on the application of the transmission disequilibrium test when a parent is missing. , 1995, American journal of human genetics.

[74]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[75]  K H Buetow,et al.  A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). , 1994, Science.

[76]  W. Ewens,et al.  Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). , 1993, American journal of human genetics.

[77]  R. Klein,et al.  Onset of NIDDM occurs at Least 4–7 yr Before Clinical Diagnosis , 1992, Diabetes Care.

[78]  N. Risch.  Linkage strategies for genetically complex traits. II. The power of affected relative pairs. , 1990, American journal of human genetics.

[79]  E. Baráth,et al.  Fundamentals of Biostatistics. , 1992 .

[80]  J. W. Edwards,et al.  ABO Blood Groups and Secretor Character in Duodenal Ulcer , 1956 .