Quantitative analysis of hypertrophy in cardiac chambers in cyanotic tetralogy of Fallot.

Although early total corrective repair for cyanotic tetralogy of Fallot is now safely performed at many institutions, long-term complications after surgical repair have been demonstrated. Therefore, the optimal procedure and timing for surgical treatment remain controxersial. In the present study, we conducted a quantitative analysis of the hypertrophy of all four chambers of 87 autopsied hearts of cyanotic tetralogy of Fallot and 71 normal control hearts utilizing the myocardial mass index, and evaluated the progression of lesions with advancing age. In cyanotic tetralogy of Fallot, hypertrophy of the right ventricle progresses immediately after birth, with that of the right atrium developing soon after. The left side of the heart is normal or slightly atrophied which could be corrected by sufficient palliative intervention or total corrective repair. The growth curves of both ventricles were parallel to those of normal hearts for the period studied. Pulmonary atresia, palliative operation, and total corrective repair have been shown to have some influence on the morphological characteristics of hearts of cyanotic tetralogy of Fallot.

[1]  Y. Kawano,et al.  [Pathology of congenital heart disease in adulthood]. , 1995, Japanese circulation journal.

[2]  T. Izumi,et al.  Development of left ventricular muscle in tetralogy of Fallot. , 1984, Japanese circulation journal.

[3]  T. Graham,et al.  Hypoplasia of the left ventricle: rare cause of postoperative mortality in tetralogy of Fallot. , 1977, The American journal of cardiology.

[4]  M. Kato.  [Pathohistological studies of right ventricular hypertrophy in tetralogy of Fallot]. , 1976, [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai.

[5]  Y. Kawashima,et al.  Right ventricular hypertrophy in tetralogy of Fallot. , 1976, Recent advances in studies on cardiac structure and metabolism.

[6]  P. Jewett,et al.  Left Heart Function in Children with Tetralogy of Fallot before and after Palliative or Corrective Surgery , 1972, Circulation.

[7]  M. Lev,et al.  Mass indices of the ventricles at autopsy in children. , 1971, American heart journal.

[8]  S. Rahimtoola,et al.  Volume of the left ventricle in tetralogy of Fallot. , 1965, The American journal of cardiology.

[9]  M. Lev,et al.  The Quantitative Anatomy of Cyanotic Tetralogy of Fallot , 1964, Circulation.

[10]  F. Eckner,et al.  THE PATHOLOGIC ANATOMY OF TETRALOGY OF FALLOT AND ITS VARIATIONS. , 1964, Diseases of the chest.

[11]  M. Lev,et al.  The Quantitative Anatomy of the Normal Child's Heart , 1963 .

[12]  M. Lev,et al.  Pathologic methods for study of congenitally malformed heart. Methods for electrocardiographic and physiologic correlation. , 1961, Archives of pathology.