Ethical challenges of clinical trials with a repurposed drug in outbreaks
暂无分享,去创建一个
[1] J. Kimmelman,et al. Competition for recruitment in SARS-CoV-2 Trials in the United States: a longitudinal cohort analysis , 2022, BMC research notes.
[2] Mariusz Maziarz,et al. The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidence , 2022, History and Philosophy of the Life Sciences.
[3] Lada Leyens,et al. The COVID-19 pandemic as a catalyst for innovation: a regulatory framework to assess fit-for-purpose innovative approaches in clinical research , 2022, Trials.
[4] L. Guizzaro,et al. The Impact of COVID‐19 on the Initiation of Clinical Trials in Europe and the United States , 2022, Clinical pharmacology and therapeutics.
[5] M. G. Jeppesen,et al. Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro , 2021, Communications Biology.
[6] M. G. Jeppesen,et al. Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro , 2021, Communications Biology.
[7] C. Yap,et al. Implementation of platform trials in the COVID-19 pandemic: A rapid review , 2021, Contemporary Clinical Trials.
[8] A. Caplan,et al. Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Diseases? , 2021, The American journal of bioethics : AJOB.
[9] J. Al-Hashel,et al. Effect of Pre-exposure Use of Amantadine on COVID-19 Infection: A Hospital-Based Cohort Study in Patients With Parkinson's Disease or Multiple Sclerosis , 2021, Frontiers in Neurology.
[10] J. Bukh,et al. Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro , 2021, Viruses.
[11] J. Baell,et al. Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers , 2021, Science Translational Medicine.
[12] J. Kimmelman,et al. How informative were early SARS-CoV-2 treatment and prevention trials? a longitudinal cohort analysis of trials registered on ClinicalTrials.gov , 2021, medRxiv.
[13] P. Venkatesan. Repurposing drugs for treatment of COVID-19 , 2021, The Lancet Respiratory Medicine.
[14] D. Sahoo,et al. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions , 2021, Nature Communications.
[15] G. Aranda-Abreu,et al. The efficacy of amantadine hydrochloride in the treatment of COVID-19 - a single-center observation study. , 2021, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
[16] I. Rooman,et al. Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research , 2021, Trials.
[17] Jay J H Park,et al. How COVID-19 has fundamentally changed clinical research in global health , 2021, The Lancet Global Health.
[18] W. Danysz,et al. Amantadine Inhibits SARS-CoV-2 In Vitro , 2021, Viruses.
[19] J. Ioannidis,et al. Challenges and Lessons Learned From COVID-19 Trials: Should We Be Doing Clinical Trials Differently? , 2021, Canadian Journal of Cardiology.
[20] B. Sahoo,et al. Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection , 2021, Frontiers in Molecular Biosciences.
[21] B. Wilfond,et al. An ethics framework for consolidating and prioritizing COVID-19 clinical trials , 2021, Clinical trials.
[22] Nina S. Hsu,et al. Ethical considerations of COVID-19-related adjustments to clinical research , 2021, Nature Medicine.
[23] Julian Matschinske,et al. Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies , 2021, Nature Computational Science.
[24] T. Bubela,et al. Let’s Do Better: Public Representations of COVID-19 Science , 2020 .
[25] Daria Kim,et al. Redundant trials can be prevented, if the EU clinical trial regulation is applied duly , 2020, BMC medical ethics.
[26] A. Kesselheim,et al. Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19 , 2020, BMJ.
[27] J. Mancilla-Galindo,et al. Use of antivirals and antibiotics for COVID-19 in Mexico City: A Real-World Multicenter Cohort Study , 2020, medRxiv.
[28] M. Hernández-Aguilar,et al. Observational study of people infected with SARS-Cov-2, treated with amantadine , 2020, Pharmacological Reports.
[29] Gillian Ferry,et al. It is unprecedented: trial management during the COVID-19 pandemic and beyond , 2020, Trials.
[30] Martin A. Tanner,et al. Forecasting for COVID-19 has failed , 2020, International Journal of Forecasting.
[31] S. Chanda,et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing , 2020, Nature.
[32] Eytan Ruppin,et al. Discovery of SARS-CoV-2 Antivirals through Large-scale Drug Repositioning , 2020, Nature.
[33] G. Aranda-Abreu,et al. Use of amantadine in a patient with SARS‐CoV‐2 , 2020, Journal of medical virology.
[34] A. Cortés Borra. Does amantadine have a protective effect against COVID-19? , 2020, Neurologia i neurochirurgia polska.
[35] Tracey Williams,et al. The impact of COVID-19 , 2020, Journal of perioperative practice.
[36] Konrad Rejdak,et al. Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment , 2020, Multiple Sclerosis and Related Disorders.
[37] M. Polymeropoulos,et al. Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment , 2020, International Journal of Antimicrobial Agents.
[38] Gonzalo Emiliano Aranda Abreu,et al. Amantadine as a drug to mitigate the effects of COVID-19 , 2020, Medical Hypotheses.
[39] Ross Upshur,et al. Panic prescribing has become omnipresent during the COVID-19 pandemic. , 2020, The Journal of clinical investigation.
[40] Alex John London,et al. Against pandemic research exceptionalism , 2020, Science.
[41] D. Strech,et al. Results dissemination of registered clinical trials across Polish academic institutions: a cross-sectional analysis , 2020, BMJ Open.
[42] Taha Nisar,et al. Antiviral amantadine , 2019, The Lancet Neurology.
[43] Vivek Gupta,et al. Drug repurposing: a promising tool to accelerate the drug discovery process. , 2019, Drug discovery today.
[44] B. Strom,et al. Trends in Off-Label Drug Use in Ambulatory Settings: 2006–2015 , 2019, Pediatrics.
[45] S. Goodman,et al. Harms From Uninformative Clinical Trials. , 2019, JAMA.
[46] P. Sanseau,et al. Drug repurposing: progress, challenges and recommendations , 2018, Nature Reviews Drug Discovery.
[47] J. Locascio,et al. Randomised controlled trials – the gold standard for effectiveness research , 2018, BJOG : an international journal of obstetrics and gynaecology.
[48] L. Chew,et al. Off‐label drug use in oncology: a systematic review of literature , 2017, Journal of clinical pharmacy and therapeutics.
[49] D. Wendler,et al. In Defense of a Social Value Requirement for Clinical Research , 2017, Bioethics.
[50] Rieke van der Graaf,et al. International Ethical Guidelines for Health-related Research involving Humans , 2017 .
[51] J. V. van Delden,et al. What do international ethics guidelines say in terms of the scope of medical research ethics? , 2016, BMC medical ethics.
[52] J. Connor,et al. The platform trial: an efficient strategy for evaluating multiple treatments. , 2015, JAMA.
[53] V. Rajadhyaksha. Conducting Feasibilities in Clinical Trials: An Investment to Ensure a Good Study , 2010, Perspectives in clinical research.
[54] R. Dooling,et al. MASKING , 2008, The SAGE Encyclopedia of Research Design.
[55] T. Ashburn,et al. Drug repositioning: identifying and developing new uses for existing drugs , 2004, Nature Reviews Drug Discovery.
[56] J. Hanley,et al. Association of Off-label Drug Use and Adverse Drug Events in an Adult Population. , 2016, JAMA internal medicine.
[57] P. Leung. An ethics framework , 2005 .