Application of the process modeling tool PROMOT to the modeling of metabolic networks

The process modeling tool ProMoT [6, 5] has been developed for the object-oriented and equation-based modeling of chemical processes. This contribution presents the application of ProMoT to a novel application field: the design and implementation of a knowledge base for modeling metabolic networks in living cells. This knowledge base contains predefined modeling entities for the hierarchical aggregation of complex reaction network models. The principles of defining primitive metabolic entities as well as the construction of a flexible knowledge base for modeling larger metabolic networks are presented.