High and Low Energy FAB Tandem Mass Spectrometry of a Series of Anomeric and Regioisomeric 2′-Deoxyribofuranosyl Imidazole Nucleosides

Abstract Positive ion fast atom bombardment mass spectrometry has aided the structural characterisation of a novel series of anomeric and regioisomeric ethyl 5- and 4-amino-2′ -deoxy-D-erythro-pentofuranosylimidazole-4- and 5 carboxylate nucleosides. Daughter ion MS/MS analyses (high energy MIKE and low energy MS/MS CAD), of the precursor protonated molecular ions for this series of anomeric and regioisomeric nucleosides have provided distinct and reproducible fingerprint patterns which have permitted discrimination between the individual configurations of the various anomers and regioisomers.

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