Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)
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[1] Michael L. Miller,et al. An intramolecular 1,3-dipolar cycloaddition approach to a pyrimidoazepinone derivative. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives , 1996 .
[2] R. Schultz,et al. Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. , 1995, Molecular pharmacology.
[3] C. J. Barnett,et al. ASYMMETRIC SYNTHESIS OF LOMETREXOL ((6R)-5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID) , 1994 .
[4] R. Schultz,et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. , 1994, Cancer research.
[5] C. Shih,et al. Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF) , 1993 .
[6] N. Lehman,et al. Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells. , 1993, Cancer research.
[7] L. Walensky,et al. Synthesis of 10-Substituted “Open-Chain” Analogues of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF, Lometrexol) , 1992 .
[8] A. Tse,et al. Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. , 1991, Biochemistry.
[9] G. P. Beardsley,et al. Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines. , 1991, Molecular pharmacology.
[10] P. M. Harrington,et al. A convergent synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrohomofolic acid. An effective principle for carbonyl group activation , 1990 .
[11] C. Shih,et al. The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. , 1989, The Journal of biological chemistry.
[12] C. Caperelli. Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities. , 1989, The Journal of biological chemistry.
[13] Z. Kaminski. 2‐CHLORO‐4,6‐DISUBSTITUTED‐1,3,5‐TRIAZINES. A NOVEL GROUP OF CONDENSING REAGENTS , 1985 .
[14] W. T. Borden,et al. A new synthesis of bicyclo [4.1.1] octa-2,4-diene and its cycloaddition reactions with dienophiles , 1985 .
[15] L. Mander,et al. Regioselective synthesis of β-ketoesters from lithium enolates and methyl cyanoformate , 1984 .