Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

[1]  Michael L. Miller,et al.  An intramolecular 1,3-dipolar cycloaddition approach to a pyrimidoazepinone derivative. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives , 1996 .

[2]  R. Schultz,et al.  Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. , 1995, Molecular pharmacology.

[3]  C. J. Barnett,et al.  ASYMMETRIC SYNTHESIS OF LOMETREXOL ((6R)-5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID) , 1994 .

[4]  R. Schultz,et al.  A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. , 1994, Cancer research.

[5]  C. Shih,et al.  Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF) , 1993 .

[6]  N. Lehman,et al.  Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells. , 1993, Cancer research.

[7]  L. Walensky,et al.  Synthesis of 10-Substituted “Open-Chain” Analogues of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF, Lometrexol) , 1992 .

[8]  A. Tse,et al.  Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. , 1991, Biochemistry.

[9]  G. P. Beardsley,et al.  Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines. , 1991, Molecular pharmacology.

[10]  P. M. Harrington,et al.  A convergent synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrohomofolic acid. An effective principle for carbonyl group activation , 1990 .

[11]  C. Shih,et al.  The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. , 1989, The Journal of biological chemistry.

[12]  C. Caperelli Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities. , 1989, The Journal of biological chemistry.

[13]  Z. Kaminski 2‐CHLORO‐4,6‐DISUBSTITUTED‐1,3,5‐TRIAZINES. A NOVEL GROUP OF CONDENSING REAGENTS , 1985 .

[14]  W. T. Borden,et al.  A new synthesis of bicyclo [4.1.1] octa-2,4-diene and its cycloaddition reactions with dienophiles , 1985 .

[15]  L. Mander,et al.  Regioselective synthesis of β-ketoesters from lithium enolates and methyl cyanoformate , 1984 .