Impaired awareness of hypoglycaemia: a review.

[1]  B. Frier,et al.  Frequency of symptomatic and asymptomatic hypoglycaemia in Type 1 diabetes: effect of impaired awareness of hypoglycaemia , 2010, Diabetic medicine : a journal of the British Diabetic Association.

[2]  B. Thorsteinsson,et al.  Classification of hypoglycemia awareness in people with type 1 diabetes in clinical practice. , 2010, Journal of diabetes and its complications.

[3]  I. Conget,et al.  Sustained efficacy of continuous subcutaneous insulin infusion in type 1 diabetes subjects with recurrent non-severe and severe hypoglycemia and hypoglycemia unawareness: a pilot study. , 2010, Diabetes technology & therapeutics.

[4]  C. Emery,et al.  Frequency of biochemical hypoglycaemia in adults with Type 1 diabetes with and without impaired awareness of hypoglycaemia: no identifiable differences using continuous glucose monitoring , 2010, Diabetic medicine : a journal of the British Diabetic Association.

[5]  W. Kenneth Ward,et al.  Novel Use of Glucagon in a Closed-Loop System for Prevention of Hypoglycemia in Type 1 Diabetes , 2010, Diabetes Care.

[6]  S. Maloney,et al.  Recurrent Moderate Hypoglycemia Ameliorates Brain Damage and Cognitive Dysfunction Induced by Severe Hypoglycemia , 2010, Diabetes.

[7]  B. Frier,et al.  Prevalence of impaired awareness of hypoglycaemia and frequency of hypoglycaemia in insulin-treated type 2 diabetes. , 2010, Diabetes research and clinical practice.

[8]  K. Borch-Johnsen,et al.  Prospective and retrospective recording of severe hypoglycaemia, and assessment of hypoglycaemia awareness in insulin‐treated Type 2 diabetes , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[9]  A. Fritsche,et al.  Insulin detemir causes increased symptom awareness during hypoglycaemia compared to human insulin , 2009, Diabetes, obesity & metabolism.

[10]  R. McCrimmon Glucose Sensing During Hypoglycemia: Lessons From the Lab , 2009, Diabetes Care.

[11]  M. Hallschmid,et al.  Hypoglycemia Unawareness in Older Compared With Middle-Aged Patients With Type 2 Diabetes , 2009, Diabetes Care.

[12]  S. Amiel,et al.  Hypoglycemia Unawareness Is Associated With Reduced Adherence to Therapeutic Decisions in Patients With Type 1 Diabetes , 2009, Diabetes Care.

[13]  A. Ertl,et al.  Effects of Intensive Therapy and Antecedent Hypoglycemia on Counterregulatory Responses to Hypoglycemia in Type 2 Diabetes , 2009, Diabetes.

[14]  P. Lucidi,et al.  Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans , 2009, Diabetes.

[15]  Amanda Jiménez,et al.  Glycaemic profile characteristics and frequency of impaired awareness of hypoglycaemia in subjects with T1D and repeated hypoglycaemic events , 2009, Acta Diabetologica.

[16]  A. Ertl,et al.  Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes , 2008, Diabetes.

[17]  S. Heller Minimizing Hypoglycemia While Maintaining Glycemic Control in Diabetes , 2008, Diabetes.

[18]  P. Cryer,et al.  Terbutaline and the Prevention of Nocturnal Hypoglycemia in Type 1 Diabetes , 2008, Diabetes Care.

[19]  C. Ricordi,et al.  Restoration of Hypoglycemia Awareness After Islet Transplantation , 2008, Diabetes Care.

[20]  R. McCrimmon The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes , 2008, Diabetic medicine : a journal of the British Diabetic Association.

[21]  B. Frier,et al.  Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes , 2008, Diabetic medicine : a journal of the British Diabetic Association.

[22]  I. Deary,et al.  Delayed Recovery of Cognitive Function Following Hypoglycemia in Adults With Type 1 Diabetes , 2008, Diabetes.

[23]  J. Price,et al.  Attenuation of Counterregulatory Responses to Recurrent Hypoglycemia by Active Thalamic Inhibition , 2008, Diabetes.

[24]  P. Mullins,et al.  Changing the glucose cut-off values that define hypoglycaemia has a major effect on reported frequencies of hypoglycaemia , 2008, Diabetologia.

[25]  B. Frier Defining hypoglycaemia: what level has clinical relevance? , 2008, Diabetologia.

[26]  P. Cryer,et al.  Preventing hypoglycaemia: what is the appropriate glucose alert value? , 2008, Diabetologia.

[27]  P. Marsden,et al.  Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes , 2007, Diabetes.

[28]  Brian M. Frier,et al.  An Evaluation of Methods of Assessing Impaired Awareness of Hypoglycemia in Type 1 Diabetes , 2007, Diabetes Care.

[29]  M. Strachan Frequency, Causes and Risk Factors for Hypoglycaemia in Type 1 Diabetes , 2007 .

[30]  D. Pearson,et al.  Hypoglycaemia in Pregnancy , 2007 .

[31]  B. Frier Impaired Awareness of Hypoglycaemia , 2007 .

[32]  M. Bohland,et al.  Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia. , 2007, American journal of physiology. Endocrinology and metabolism.

[33]  B. Frier,et al.  Hypoglycaemia in clinical diabetes , 2007 .

[34]  M. Brammer,et al.  Caffeine restores regional brain activation in acute hypoglycaemia in healthy volunteers , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[35]  P. Cleary,et al.  Long-term effect of diabetes and its treatment on cognitive function. , 2007, The New England journal of medicine.

[36]  A. Berghold,et al.  Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus. , 2007, The Cochrane database of systematic reviews.

[37]  J. Born,et al.  Defective Awakening Response to Nocturnal Hypoglycemia in Patients with Type 1 Diabetes Mellitus , 2007, PLoS medicine.

[38]  UK Prospective Diabetes Study Group Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration , 2007, Diabetologia.

[39]  C. Tack,et al.  Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes. , 2006, The Netherlands journal of medicine.

[40]  P. Smits,et al.  Preserved sensitivity to beta2-adrenergic receptor agonists in patients with type 1 diabetes mellitus and hypoglycemia unawareness. , 2006, The Journal of clinical endocrinology and metabolism.

[41]  P. Cryer,et al.  Nocturnal hypoglycemia in type 1 diabetes: an assessment of preventive bedtime treatments. , 2006, The Journal of clinical endocrinology and metabolism.

[42]  K. Petersen,et al.  Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. , 2006, Diabetes.

[43]  C. Cobelli,et al.  Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit. , 2006, American journal of physiology. Endocrinology and metabolism.

[44]  P. Cryer Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. , 2005, Diabetes.

[45]  P. K. Marsden,et al.  Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-d-glucose PET study , 2005, Diabetologia.

[46]  Workgroup on Hypoglycemia Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. , 2005, Diabetes care.

[47]  B. Richter,et al.  'Human' insulin versus animal insulin in people with diabetes mellitus. , 2005, The Cochrane database of systematic reviews.

[48]  Philip Hougaard,et al.  Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection , 2004, Diabetes/metabolism research and reviews.

[49]  W. Duckworth,et al.  Factors affecting hypoglycemia awareness in insulin-treated type 2 diabetes: The Diabetes Outcomes in Veterans Study (DOVES). , 2004, Diabetes research and clinical practice.

[50]  P. Cryer Diverse causes of hypoglycemia-associated autonomic failure in diabetes. , 2004, The New England journal of medicine.

[51]  T. Kubiak,et al.  Assessment of hypoglycaemia awareness using continuous glucose monitoring , 2004, Diabetic medicine : a journal of the British Diabetic Association.

[52]  I. Macdonald,et al.  Physiological response to postural change during mild hypoglycaemia in patients with IDDM , 1994, Diabetologia.

[53]  I. Deary,et al.  Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis , 1993, Diabetologia.

[54]  I. Macdonald,et al.  Alcohol causes hypoglycaemic unawareness in healthy volunteers and patients with Type 1 (insulin-dependent) diabetes , 1990, Diabetologia.

[55]  I. Macdonald,et al.  Counterregulation in Type 2 (non-insulin-dependent) diabetes mellitus. Normal endocrine and glycaemic responses, up to ten years after diagnosis , 1987, Diabetologia.

[56]  I. Deary,et al.  Hypoglycaemia in insulin‐treated Type 2 diabetes: frequency, symptoms and impaired awareness , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[57]  P. Cryer,et al.  Sleep-related hypoglycemia-associated autonomic failure in type 1 diabetes: reduced awakening from sleep during hypoglycemia. , 2003, Diabetes.

[58]  K. Borch-Johnsen,et al.  The impact of severe hypoglycemia and impaired awareness of hypoglycemia on relatives of patients with type 1 diabetes. , 2003, Diabetes care.

[59]  P. Cryer,et al.  Hypoglycemia-associated autonomic failure in advanced type 2 diabetes. , 2002, Diabetes.

[60]  P. Marsden,et al.  Changes in regional brain (18)F-fluorodeoxyglucose uptake at hypoglycemia in type 1 diabetic men associated with hypoglycemia unawareness and counter-regulatory failure. , 2001, Diabetes.

[61]  T. Videen,et al.  Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. , 2001, Diabetes.

[62]  M. Stumvoll,et al.  Avoidance of Hypoglycemia Restores Hypoglycemia Awareness by Increasing -Adrenergic Sensitivity in Type 1 Diabetes , 2001, Annals of Internal Medicine.

[63]  A. Hattersley,et al.  Hypoglycaemic counter-regulation at normal blood glucose concentrations in patients with well controlled type-2 diabetes , 2000, The Lancet.

[64]  R. Stolk,et al.  Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia. , 2000, Diabetes care.

[65]  C. Airey,et al.  Hypoglycaemia induced by exogenous insulin –‘human’ and animal insulin compared , 2000, Diabetic medicine : a journal of the British Diabetic Association.

[66]  S. Davis,et al.  Gender-related differences in counterregulatory responses to antecedent hypoglycemia in normal humans. , 2000, The Journal of clinical endocrinology and metabolism.

[67]  R. Heine,et al.  Assessing impaired hypoglycemia awareness in type 1 diabetes: agreement of self-report but not of field study data with the autonomic symptom threshold during experimental hypoglycemia. , 2000, Diabetes care.

[68]  B P Kovatchev,et al.  Progressive hypoglycemia's impact on driving simulation performance. Occurrence, awareness and correction. , 2000, Diabetes care.

[69]  J. Wahren,et al.  Brain substrate utilisation during acute hypoglycaemia , 1999, Diabetologia.

[70]  P. Cryer,et al.  Durable reversal of hypoglycemia unawareness in type 1 diabetes. , 1999, Diabetes care.

[71]  I. Mühlhauser,et al.  Risk factors of severe hypoglycaemia in adult patients with Type I diabetes – a prospective population based study , 1998, Diabetologia.

[72]  R. Heine,et al.  Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycaemia in IDDM , 1998, Diabetologia.

[73]  T. Jones,et al.  Decreased epinephrine responses to hypoglycemia during sleep. , 1998, The New England journal of medicine.

[74]  A. Björklund Hypoglycaemia in pregnancy : Hypoglycaemic clamp studies during and after pregnancy in women with IDDM , 1998 .

[75]  I. Deary,et al.  Perceived symptoms of hypoglycaemia in elderly Type 2 diabetic patients treated with insulin , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[76]  W. Kerner,et al.  Acute stress modulates symptom awareness and hormonal counterregulation during insulin-induced hypoglycemia in healthy individuals , 1998, International journal of behavioral medicine.

[77]  T. Veneman,et al.  Hypoglycemia Unawareness in Noninsulin-Dependent Diabetes Mellitus , 1997 .

[78]  I. Cranston,et al.  Altered Hierarchy of Protective Responses Against Severe Hypoglycemia in Normal Aging in Healthy Men , 1997, Diabetes Care.

[79]  G. Shulman,et al.  Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. , 1997, The Journal of clinical investigation.

[80]  S. Davis,et al.  Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans. , 1996, The Journal of clinical investigation.

[81]  Ian J. Deary,et al.  Hypoglycemia-induced cognitive dysfunction in diabetes mellitus: Effect of hypoglycemia unawareness , 1995, Physiology & Behavior.

[82]  K. Alberti,et al.  Reduced awareness of hypoglycaemia in the elderly despite an intact counter-regulatory response. , 1995, QJM : monthly journal of the Association of Physicians.

[83]  D. Cox,et al.  Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptoms , 1995, Diabetes Care.

[84]  P. Cryer,et al.  Reversal of Hypoglycemia Unawareness, But Not Defective Glucose Counterregulation, in IDDM , 1994, Diabetes.

[85]  I. Deary,et al.  Structural Equation Modeling of Symptoms, Awareness and Fear of Hypoglycemia, and Personality in Patients With Insulin-Treated Diabetes , 1994, Diabetes Care.

[86]  A. Maran,et al.  Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes , 1994, The Lancet.

[87]  B. Frier,et al.  Frequency of Severe Hypoglycemia in Patients With Type I Diabetes With Impaired Awareness of Hypoglycemia , 1994, Diabetes Care.

[88]  P. Cryer,et al.  Hypoglycemia Unawareness in IDDM , 1993, Diabetes Care.

[89]  Ian J. Deary,et al.  Hypoglycaemia unawareness in adult patients with Type 1 diabetes: Relationship to severe hypoglycaemia and cognitive impairment. , 1994 .

[90]  P. Cryer Hypoglycemia Unawareness in IDDM , 1993, Diabetes Care.

[91]  P. Cryer,et al.  Mechanism of Awareness of Hypoglycemia: Perception of Neurogenic (Predominantly Cholinergic) Rather Than Neuroglycopenic Symptoms , 1993, Diabetes.

[92]  Paolo Brunetti,et al.  Meticulous Prevention of Hypoglycemia Normalizes the Glycemic Thresholds and Magnitude of Most of Neuroendocrine Responses to, Symptoms of, and Cognitive Function During Hypoglycemia in Intensively Treated Patients With Short-Term IDDM , 1993, Diabetes.

[93]  W. Tamborlane,et al.  Effect of Caffeine on the Recognition of and Responses to Hypoglycemia in Humans , 1993, Annals of Internal Medicine.

[94]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[95]  P. Cryer,et al.  Induction of Hypoglycemia Unawareness by Asymptomatic Nocturnal Hypoglycemia , 1993, Diabetes.

[96]  D. Cox,et al.  Perceived Symptoms in the Recognition of Hypoglycemia , 1993, Diabetes Care.

[97]  B. Frier,et al.  Hypoglycaemia Unawareness in Type 1 Diabetes: A Lower Plasma Glucose is Required to Stimulate Sympathoadrenal Activation , 1991, Diabetic medicine : a journal of the British Diabetic Association.

[98]  H. Shamoon,et al.  Counterregulatory adaptation to recurrent hypoglycemia in normal humans. , 1991, The Journal of clinical endocrinology and metabolism.

[99]  I. Deary,et al.  Symptoms of Acute Insulin-Induced Hypoglycemia in Humans With and Without IDDM: Factor-Analysis Approach , 1991, Diabetes Care.

[100]  I. Hirsch,et al.  Higher Glycemic Thresholds for Symptoms During β-Adrenergic Blockade in IDDM , 1991, Diabetes.

[101]  C. Binder,et al.  Symptomatic Hypoglycaemia in 411 Type 1 Diabetic Patients , 1991, Diabetic medicine : a journal of the British Diabetic Association.

[102]  I. Hirsch,et al.  Higher glycemic thresholds for symptoms during beta-adrenergic blockade in IDDM. , 1991, Diabetes.

[103]  Epidemiology of severe hypoglycemia in the diabetes control and complications trial. The DCCT Research Group. , 1991, The American journal of medicine.

[104]  I Kiss,et al.  Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. , 1991, The American journal of physiology.

[105]  T. M. Hayes,et al.  Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy. , 1990, BMJ.

[106]  D. Ewing,et al.  Unawareness of Hypoglycaemia in Insulin‐treated Diabetic Patients: Prevalence and Relationship to Autonomic Neuropathy , 1990, Diabetic medicine : a journal of the British Diabetic Association.

[107]  I. Macdonald,et al.  Beta-adrenoceptor blockade and hypoglycaemia. A randomised, double-blind, placebo controlled comparison of metoprolol CR, atenolol and propranolol LA in normal subjects. , 1990, British journal of clinical pharmacology.

[108]  E. Jaeggi,et al.  WARNING SYMPTOMS OF HYPOGLYCAEMIA DURING TREATMENT WITH HUMAN AND PORCINE INSULIN IN DIABETES MELLITUS , 1989, The Lancet.

[109]  A. Cherrington,et al.  Role of Brain in Counterregulation of Insulin-Induced Hypoglycemia in Dogs , 1989, Diabetes.

[110]  P. Cryer,et al.  Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. , 1988, The New England journal of medicine.

[111]  A. Barnes,et al.  AWARENESS OF HYPOGLYCAEMIA IN DIABETES , 1987, The Lancet.

[112]  P. Cryer,et al.  Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. , 1987, The Journal of clinical investigation.

[113]  J. Potter,et al.  Insulin-induced hypoglycaemia in an accident and emergency department: the tip of an iceberg? , 1982, British medical journal.

[114]  J. Gerich,et al.  Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect , 1973, Science.

[115]  C. Carter II.—CHROMOSOMES AND CHROMOSOME MUTATIONS , 1969 .