Analgesic and anti-inflammatory activities of Asparagus africanus root extract.

The methanolic extract of the roots of Asparagus africanus Lam (Liliaceae) which contains mainly saponins and carbohydrate showed significant analgesic and anti-inflammatory activities (P<0.05) in the tail-flick/hot-plate test and egg albumen-induced rat paw oedema tests that were comparable to the test drugs (morphine 20 mg/kg and indomethacin 50 mg/kg respectively). These results indicate that the extract possesses analgesic and anti-inflammatory properties.

[1]  D. Lorke.  A new approach to practical acute toxicity testing , 1983, Archives of Toxicology.

[2]  O. Kunert,et al.  Steroidal saponins from Asparagus africanus. , 1999, Phytochemistry.

[3]  S. Christensen,et al.  Antiprotozoal compounds from Asparagus africanus. , 1997, Journal of natural products.

[4]  W. Evans.  Trease and Evans' pharmacognosy, 14th edition , 1997 .

[5]  H. Wagner,et al.  A review of the biological and pharmacological activities of saponins. , 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[6]  B. Desta.  Ethiopian traditional herbal drugs. Part II: Antimicrobial activity of 63 medicinal plants. , 1993, Journal of ethnopharmacology.

[7]  A. Rapisarda,et al.  Analgesic and antiinflammatory activity in acute and chronic conditions of Trema guineense (Schum. et Thonn.) Ficalho and Trema micrantha Blume extracts in rodents , 1992 .

[8]  W. Evans.  Trease and Evans' Pharmacognosy , 1989 .

[9]  D. Willoughby,et al.  Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine , 1971 .

[10]  H. Mizushima.  Non-steroid anti-inflammatory agents. , 1970, British medical journal.

[11]  C. N. Gillis,et al.  Screening Methods in Pharmacology , 1965, The Yale Journal of Biology and Medicine.

[12]  C. Stammer,et al.  Non-Steroid Anti-Inflammatory Agents , 1963 .

[13]  C A WINTER,et al.  Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  J. M. Watt,et al.  The medicinal and poisonous plants of southern and eastern Africa. , 1962 .

[15]  A. R.,et al.  The Useful Plants of West Tropical Africa , 1938, Nature.

[16]  J. Dalziel,et al.  The useful plants of West Tropical Africa. , 1938 .