Immunological abnormalities in the chronic fatigue syndrome (for editorial comment, see page 117)

The chronic fatigue syndrome is a disorder of unknown aetiology which is characterized by debilitating fatigue. Recent evidence has suggested that viruses may persist in the tissues of patients with chronic fatigue syndrome. A concurrent immunological disturbance is likely to be associated with the persistence of viral antigens. Therefore, the humoral and cellular immunity of 100 patients who were suffering from chronic fatigue syndrome and that of 100 healthy, age‐ and sex‐matched control subjects were compared. This study documents the frequent occurrence of abnormalities within the cellular and humoral immune systems of patients with well‐defined chronic fatigue syndrome. Disordered immunity may be central to the pathogenesis of chronic fatigue syndrome. In patients with chronic fatigue syndrome, a significant (P<0.01) reduction was found in the absolute number of peripheral blood lymphocytes in the total T‐cell (CD2), the helper/inducer T‐cell (CD4) and the suppressor/cytotoxic T‐cell (CD8) subsets. A significant (P<0.001) reduction also was found in T‐cell function, which was measured: in vivo by delayed‐type hypersensitivity skin‐testing (reduced responses were recorded in 50 [88%] of 57 patients); and in vitro by phytohaemagglutinin stimulation. Reduced immunoglobulin (Ig) levels were common (56% of patients), with the levels of serum lgG3‐ and IgG1‐subclasses particularly (P<0.05) affected.

[1]  S. Gandevia,et al.  Muscle strength, endurance and recovery in the post-infection fatigue syndrome. , 1988, Journal of neurology, neurosurgery, and psychiatry.

[2]  P. Holborow,et al.  Pathophysiology of myalgic encephalomyelitis , 1988, The Medical journal of Australia.

[3]  James F. Jones,et al.  Chronic fatigue syndrome: a working case definition. , 1988, Annals of internal medicine.

[4]  G. Yousef,et al.  CHRONIC ENTEROVIRUS INFECTION IN PATIENTS WITH POSTVIRAL FATIGUE SYNDROME , 1988, The Lancet.

[5]  M. Caligiuri,et al.  Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. , 1987, Journal of immunology.

[6]  H. Thomas,et al.  INTERFERONS AS MEDIATORS OF PSYCHIATRIC MORBIDITY An Investigation in a Trial of Recombinant α-Interferon in Hepatitis-B Carriers , 1987, The Lancet.

[7]  P. Pinsky,et al.  A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause? , 1987, JAMA.

[8]  B. Rouse,et al.  Immunosuppression in Viral Infections , 1986, Reviews of infectious diseases.

[9]  I. Mackay,et al.  Assessment of delayed-type hypersensitivity in man: a comparison of the "Multitest" and conventional intradermal injection of six antigens. , 1985, Clinical immunology and immunopathology.

[10]  P. Behan,et al.  The postviral fatigue syndrome--an analysis of the findings in 50 cases. , 1985, The Journal of infection.

[11]  C. Ray,et al.  Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. , 1985, Annals of internal medicine.

[12]  R. Davey,et al.  Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. , 1985, Annals of internal medicine.

[13]  N. Speight,et al.  Myalgic encephalomyelitis. , 1985, The New Zealand medical journal.

[14]  J. Dwyer Anergy. The mysterious loss of immunological energy. , 1984, Progress in allergy.

[15]  A. Meshorer,et al.  Involvement of interferon in virus-induced lymphopenia. , 1983, Cellular immunology.

[16]  W. D. Winters,et al.  Specific immune responses to skin test antigens following repeated multiple antigen skin tests in normal individuals. , 1982, Clinical and experimental immunology.

[17]  E. Reinherz,et al.  The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. , 1980, Journal of immunology.

[18]  N. Blumberg Manual of Clinical Immunology , 1977, The Yale Journal of Biology and Medicine.

[19]  L. Herzenberg,et al.  ANALYSIS OF CELL POPULATIONS WITH A FLUORESCENCE‐ACTIVATED CELL SORTER * , 1975, Annals of the New York Academy of Sciences.

[20]  H. Walther [Epidemic myalgic encephalomyelitis]. , 1972, Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.

[21]  S. Alexander,et al.  Lymphocyte Transformation , 1972, The British journal of dermatology.