论文信息 - Synthesis and “in Vitro” Antimicrobial Properties of N‐Oxide Derivatives Based on Tricyclic Indeno[2,1‐c]pyridazine and Benzo[f]cinnoline Systems

Synthesis and “in Vitro” Antimicrobial Properties of N‐Oxide Derivatives Based on Tricyclic Indeno[2,1‐c]pyridazine and Benzo[f]cinnoline Systems

A number of 9H‐indeno[2,1‐c]pyridazine N‐oxides (3a—c) and benzo[f]cinnoline N‐oxides (4,5a—c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9‐nitro‐benzo[f]cinnoline N‐oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 μg/ml).

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