Reproductive and hormonal factors, family history, and breast cancer according to the hormonal receptor status

The aim of this study was to investigate the association between breast cancer risk, reproductive factors, and family history of breast cancer by the estrogen receptor (ER) and progesterone receptor (PR) status. We analyzed data from an Italian case–control study including 1075 women with incident breast cancer and 1477 hospital controls. We estimated the odds ratios (ORs) of breast cancer using unconditional logistic regression models including major recognized risk factors for breast cancer. Stronger associations with ER+ than with ER− breast cancer were observed for parity (OR: 0.7 vs. 0.9 for ≥3 births vs. nulliparae), age at first birth (OR: 1.6 vs. 1.2 for age ≥30 vs. <25 years), menopausal status (OR: 0.7 vs. 0.8 for postmenopause vs. pre/perimenopause), age at menopause (OR: 1.3 vs. 1.2 for menopause at age ≥50 vs. <50 years), and family history of breast cancer (OR: 2.2 vs. 1.4). Among the ER+ patients, the presence of PR+ did not appreciably modify any of the risk estimates. The association with age at menarche and hormone replacement therapy use was neither significant nor heterogeneous across ER and PR subtypes. In conclusion, we found stronger associations with selected menstrual and reproductive factors for ER+ (PR+) than for ER− (PR−) breast cancers, though in the absence of significant heterogeneity.

[1]  C. la Vecchia,et al.  Attributable risks for breast cancer in Italy: Education, family history and reproductive and hormonal factors , 1997, International journal of cancer.

[2]  A. Ashworth,et al.  Pregnancy and the risk of breast cancer. , 2007, Endocrine-related cancer.

[3]  D. Horsfall,et al.  Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study. , 1989, British Journal of Cancer.

[4]  Paul D. Allison,et al.  Logistic Regression Using the SAS System : Theory and Application , 1999 .

[5]  M. Inoue,et al.  Role and impact of menstrual and reproductive factors on breast cancer risk in Japan , 2007, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[6]  Graham A Colditz,et al.  Risk factors for breast cancer according to estrogen and progesterone receptor status. , 2004, Journal of the National Cancer Institute.

[7]  V. McCormack,et al.  Height, age at menarche and risk of hormone receptor‐positive and ‐negative breast cancer: A cohort study , 2013, International journal of cancer.

[8]  E. White,et al.  Short Communication Relationship between Age Maximum Height Is Attained, Age at Menarche, and Age at First Full-Term Birth and Breast Cancer Risk , 2007 .

[9]  P. Porter,et al.  Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20–44 years of age , 2012, Breast Cancer Research and Treatment.

[10]  G. Anderson,et al.  Predicting risk of breast cancer in postmenopausal women by hormone receptor status. , 2007, Journal of the National Cancer Institute.

[11]  K. Kerlikowske,et al.  Reproductive history and risk of three breast cancer subtypes defined by three biomarkers , 2011, Cancer Causes & Control.

[12]  Heather Eliassen,et al.  Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies , 2012, The Lancet. Oncology.

[13]  C. la Vecchia,et al.  An assessment, and reproducibility of food frequency data provided by hospital controls. , 1997, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[14]  M. Pike,et al.  Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies , 2006, Breast Cancer Research.

[15]  N. Breslow,et al.  The analysis of case-control studies , 1980 .

[16]  R C Millikan,et al.  Hormone-related factors and risk of breast cancer in relation to estrogen receptor and progesterone receptor status. , 2000, American journal of epidemiology.

[17]  Á. Carracedo,et al.  Family History and Breast Cancer Hormone Receptor Status in a Spanish Cohort , 2012, PloS one.

[18]  C. la Vecchia,et al.  Nutritional factors, physical activity, and breast cancer by hormonal receptor status. , 2013, Breast.

[19]  X. Shu,et al.  Association of hormone-related characteristics and breast cancer risk by estrogen receptor/progesterone receptor status in the shanghai breast cancer study. , 2011, American journal of epidemiology.

[20]  Victoria L. Cafourek,et al.  Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. , 2011, Journal of the National Cancer Institute.

[21]  Paolo Boffetta,et al.  Risk factors according to estrogen receptor status of breast cancer patients in Trivandrum, South India , 2009, International journal of cancer.

[22]  D. Brogan,et al.  Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of age. , 2002, American journal of epidemiology.

[23]  J. Potter,et al.  Timing of menarche and first full-term birth in relation to breast cancer risk. , 2007, American journal of epidemiology.

[24]  M. García-Closas,et al.  Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[25]  T. Menes,et al.  Breast Cancer and Ethnicity: Strong Association between Reproductive Risk Factors and Estrogen Receptor Status in Asian Patients—A Retrospective Study , 2007, The breast journal.

[26]  J. Cerhan,et al.  Progesterone and estrogen receptors and mammary neoplasia in the Iowa Women's Health Study: how many kinds of breast cancer are there? , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[27]  C. la Vecchia,et al.  Reliability of data on medical conditions, menstrual and reproductive history provided by hospital controls. , 2001, Journal of clinical epidemiology.

[28]  Gretchen L. Gierach,et al.  Menopausal Hormone Therapy and Breast Cancer Risk in the NIH-AARP Diet and Health Study Cohort , 2008, Cancer Epidemiology Biomarkers & Prevention.

[29]  P. Hall,et al.  Risk Factors for Hormone Receptor-Defined Breast Cancer in Postmenopausal Women , 2006, Cancer Epidemiology Biomarkers & Prevention.

[30]  J. Palmer,et al.  Parity and Lactation in Relation to Estrogen Receptor Negative Breast Cancer in African American Women , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[31]  Y. Nishino,et al.  Reproductive factors and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women , 2012, Cancer science.

[32]  T. Sellers,et al.  Association between family history of cancer and breast cancer defined by estrogen and progesterone receptor status , 1996, Genetic epidemiology.

[33]  M. Pike,et al.  American Journal of Epidemiology Original Contribution Breast Cancer Risk Factors Defined by Estrogen and Progesterone Receptor Status the Multiethnic Cohort Study , 2022 .

[34]  P. Simpson,et al.  Statistical methods in cancer research , 2001, Journal of surgical oncology.

[35]  K. Yoo,et al.  Breast cancer risk factors according to combined estrogen and progesterone receptor status: a case-control analysis. , 1997, American journal of epidemiology.

[36]  M. Cotterchio,et al.  Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroup. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[37]  David W. Hosmer,et al.  Applied Logistic Regression , 1991 .