Cellular immune responses to HIV

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

[1]  B. Walker,et al.  HIV-specific cytotoxic T lymphocytes in seropositive individuals , 1987, Nature.

[2]  B. Autran,et al.  AIDS virus-specific cytotoxic T lymphocytes in lung disorders , 1987, Nature.

[3]  M. Clerici,et al.  Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. , 1989, The Journal of clinical investigation.

[4]  D. Nixon,et al.  High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals. , 1990, International immunology.

[5]  M. Baseler,et al.  Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population. , 1990, Journal of immunology.

[6]  Charles R. M. Bangham,et al.  Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition , 1991, Nature.

[7]  F. Miedema,et al.  Programmed death of T cells in HIV-1 infection. , 1992, Science.

[8]  D Emilie,et al.  Antagonistic effect of interferon-gamma on tat-induced transactivation of HIV long terminal repeat. , 1992, The Journal of biological chemistry.

[9]  J. Levy,et al.  CD8+ cell anti-HIV activity: nonlytic suppression of virus replication. , 1992, AIDS research and human retroviruses.

[10]  R. Siliciano,et al.  Cytokines from vaccine-induced HIV-1 specific cytotoxic T lymphocytes: effects on viral replication. , 1993, AIDS research and human retroviruses.

[11]  B. Walker,et al.  Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens , 1993, Journal of virology.

[12]  B. Walker,et al.  Induction of HIV-1 replication in a chronically infected T-cell line by cytotoxic T lymphocytes. , 1993, Journal of acquired immune deficiency syndromes.

[13]  Rolf M. Zinkernagel,et al.  Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells , 1993, Nature.

[14]  D. Richman,et al.  Mechanisms for the Inhibition of HIV Replication by Interferons-α, -β, and -γ, in Primary Human Macrophages , 1993 .

[15]  A. Ramsay,et al.  A case for cytokines as effector molecules in the resolution of virus infection. , 1993, Immunology today.

[16]  X. Jin,et al.  Quantitative analysis of the human immunodeficiency virus type 1 (HIV- 1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein- Barr virus in late disease , 1993, The Journal of experimental medicine.

[17]  G. Shaw,et al.  Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection , 1994, Journal of virology.

[18]  Functional consequences of mutations in HIV-1 Gag p55 selected by CTL pressure. , 1994, Virology.

[19]  J. Rodgers,et al.  Anergy and apoptosis in CD8+ T cells from HIV-infected persons. , 1994, Journal of immunology.

[20]  Persephone Borrow,et al.  Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV , 1994, Nature.

[21]  D. Ho,et al.  Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome , 1994, Journal of virology.

[22]  Hans Hengartner,et al.  Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice , 1994, Nature.

[23]  A. McMichael,et al.  Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques , 1995, Nature Genetics.

[24]  S. Riddell,et al.  Principles for adoptive T cell therapy of human viral diseases. , 1995, Annual review of immunology.

[25]  R. Steinman,et al.  Low levels of HIV-1 infection in cutaneous dendritic cells promote extensive viral replication upon binding to memory CD4+ T cells , 1995, The Journal of experimental medicine.

[26]  Martin A. Nowak,et al.  Antigenic oscillations and shifting immunodominance in HIV-1 infections , 1995, Nature.

[27]  S. Rowland-Jones,et al.  Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[28]  B. Walker,et al.  Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope. , 1995, Clinical immunology and immunopathology.

[29]  S. Riddell,et al.  Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. , 1995, The New England journal of medicine.

[30]  K. Rosenthal,et al.  Suppression of activation of the human immunodeficiency virus long terminal repeat by CD8+ T cells is not lentivirus specific. , 1995, AIDS research and human retroviruses.

[31]  H. Clifford Lane,et al.  Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression , 1995, Nature Medicine.

[32]  S. Arya,et al.  Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells , 1995, Science.

[33]  Philip J. R. Goulder,et al.  Phenotypic Analysis of Antigen-Specific T Lymphocytes , 1996, Science.

[34]  R P Johnson,et al.  Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes , 1996, Journal of virology.

[35]  W. Blattner,et al.  T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant , 1996, The Journal of experimental medicine.

[36]  F. Chisari,et al.  Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. , 1996, Immunity.

[37]  J. Goedert,et al.  Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection , 1996, Nature Medicine.

[38]  J. Levy,et al.  Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells. , 1996, Immunology today.

[39]  Introduction: Presentation of viral antigens to cytotoxic T cells , 1996 .

[40]  L M Wahl,et al.  Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Bell,et al.  Large clonal expansions of CD8+ T cells in acute infectious mononucleosis , 1996, Nature Medicine.

[42]  M. Rep,et al.  Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells , 1997, The Journal of experimental medicine.

[43]  R. Phillips,et al.  Patterns of Immunodominance in HIV-1–specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation , 1997, The Journal of experimental medicine.

[44]  G. Biberfeld,et al.  Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission , 1997, Journal of virology.

[45]  P. Klenerman,et al.  Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Xiping Wei,et al.  Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus , 1997, Nature Medicine.

[47]  A. McMichael,et al.  Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells , 1997, The Journal of experimental medicine.

[48]  M. Daucher,et al.  The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[49]  R P Johnson,et al.  Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms , 1997, Journal of virology.

[50]  Martin A. Nowak,et al.  Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS , 1997, Nature Medicine.

[51]  E. Rosenberg,et al.  Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. , 1997, Science.

[52]  J. Nkengasong,et al.  The puzzle of HIV‐1 subtypes in Africa , 1997, AIDS.

[53]  B. Walker,et al.  β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans , 1998, Nature.

[54]  S. Rowland-Jones,et al.  Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific , 1998, The Journal of experimental medicine.

[55]  I. Jones,et al.  The molecular basis of HIV capsid assembly , 1998, Reviews in medical virology.

[56]  J. Altman,et al.  Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function , 1998, The Journal of experimental medicine.

[57]  S. Rowland-Jones,et al.  Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. , 1998, The Journal of clinical investigation.

[58]  S. Rowland-Jones,et al.  Antigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes , 1998, Current Biology.

[59]  M A Nowak,et al.  Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. , 1998, Science.

[60]  G. Ogg,et al.  Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood , 1998, Current Biology.

[61]  B. Walker,et al.  HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes , 1998, Nature.

[62]  J. Guillet,et al.  Selection of Virus Variants and Emergence of Virus Escape Mutants after Immunization with an Epitope Vaccine , 1998, Journal of Virology.

[63]  Spyros A. Kalams,et al.  The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses , 1998, The Journal of experimental medicine.

[64]  S. Le Gall,et al.  Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. , 1998, Immunity.

[65]  M. Albert,et al.  Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs , 1998, Nature.

[66]  A. Trkola,et al.  Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines , 1998, Journal of Virology.

[67]  Polly Matzinger,et al.  A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell , 1998, Nature.

[68]  Circulating CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Individuals Have Impaired Function and Downmodulate CD3ζ, the Signaling Chain of the T-Cell Receptor Complex , 1998 .

[69]  M. Bevan,et al.  Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. , 1998, Immunity.

[70]  S. Kent,et al.  Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus , 1998, Journal of Virology.

[71]  A. Trautmann,et al.  Modifications of CD8+ T cell function during in vivo memory or tolerance induction. , 1998, Immunity.

[72]  J. Altman,et al.  Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. , 1998, Immunity.

[73]  J. Schmitz,et al.  Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. , 1999, Journal of immunology.

[74]  J. Lieberman,et al.  Viral-specific cytotoxic T lymphocytes lyse human immunodeficiency virus-infected primary T lymphocytes by the granule exocytosis pathway. , 1999, Blood.

[75]  D. Baltimore,et al.  The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. , 1999, Immunity.

[76]  J. Goedert,et al.  HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. , 1999, Science.

[77]  S. Rowland-Jones,et al.  A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers. , 1999, Journal of immunology.

[78]  C. Pitcher,et al.  HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression , 1999, Nature Medicine.

[79]  S. Riddell,et al.  In vivo migration and function of transferred HIV-1-specific cytotoxic T cells , 1999, Nature Medicine.

[80]  J. Lieberman,et al.  Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. , 1999, AIDS.

[81]  D. Montefiori,et al.  Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. , 1999, Science.

[82]  B. Walker,et al.  Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy , 1999, Journal of Virology.

[83]  S. Cusack,et al.  Head‐to‐tail dimers and interdomain flexibility revealed by the crystal structure of HIV‐1 capsid protein (p24) complexed with a monoclonal antibody Fab , 1999, The EMBO journal.

[84]  Todd M. Allen,et al.  Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef , 1999, Nature Medicine.

[85]  L. Weinberger,et al.  Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques , 1999, The Journal of experimental medicine.

[86]  M. Shapiro,et al.  Viral clearance without destruction of infected cells during acute HBV infection. , 1999, Science.

[87]  A. McMichael,et al.  Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain , 1999, The Journal of experimental medicine.

[88]  M. Nowak,et al.  Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy , 1999, Journal of Virology.

[89]  S. Rowland-Jones,et al.  Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. , 1999, Blood.

[90]  J. Schmitz,et al.  Comparative Analysis of Cytotoxic T Lymphocytes in Lymph Nodes and Peripheral Blood of Simian Immunodeficiency Virus-Infected Rhesus Monkeys , 1999, Journal of Virology.

[91]  T. Merigan,et al.  Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). , 1999, Journal of immunology.

[92]  Todd M. Allen,et al.  Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen , 1999, Journal of Virology.

[93]  L. Mollet,et al.  Cutting edge: RANTES regulates Fas ligand expression and killing by HIV-specific CD8 cytotoxic T cells. , 1999, Journal of immunology.

[94]  Rob J. de Boer,et al.  Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection , 2000, Nature Medicine.

[95]  B. Peterlin,et al.  Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. , 2000, Immunity.

[96]  P. Easterbrook,et al.  Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[97]  V. Appay,et al.  Memory CD8+ T cells in HIV infection. , 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[98]  Alessandro Sette,et al.  Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia , 2000, Nature.

[99]  Douglas D. Richman,et al.  HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function , 2000, The Journal of experimental medicine.

[100]  S. Rowland-Jones,et al.  Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection , 2000, AIDS.

[101]  Todd M. Allen,et al.  Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen1 , 2000, The Journal of Immunology.

[102]  A. Craiu,et al.  Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[103]  E. Rosenberg,et al.  Immune control of HIV-1 after early treatment of acute infection , 2000, Nature.

[104]  Douglas S Kwon,et al.  DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells , 2000, Cell.

[105]  E. Rosenberg,et al.  Functionally Inert HIV-Specific Cytotoxic T Lymphocytes Do Not Play a Major Role in Chronically Infected Adults and Children , 2000, The Journal of experimental medicine.

[106]  B. M. Flynn,et al.  Containment of Simian Immunodeficiency Virus Infection: Cellular Immune Responses and Protection from Rechallenge following Transient Postinoculation Antiretroviral Treatment , 2000, Journal of Virology.

[107]  A. McMichael,et al.  CD8(+) T-cell selection, function, and death in the primary immune response in vivo. , 2000, The Journal of clinical investigation.

[108]  S. Rowland-Jones,et al.  Skewed maturation of memory HIV-specific CD8 T lymphocytes , 2001, Nature.

[109]  Edward C. Holmes,et al.  Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses , 2001, The Journal of experimental medicine.