18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.

[1]  R. Schwartz,et al.  Radiation dermatitis: an overview , 2017, International journal of dermatology.

[2]  H. Hosseinzadeh,et al.  Pharmacological Effects of Glycyrrhiza spp. and Its Bioactive Constituents: Update and Review , 2015, Phytotherapy research : PTR.

[3]  A. Mahmoud,et al.  18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation , 2015, Genes & Nutrition.

[4]  M. Gilardi,et al.  Portrait of inflammatory response to ionizing radiation treatment , 2015, Journal of Inflammation.

[5]  Wen-jie Zheng,et al.  Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways. , 2014, Cancer letters.

[6]  Stephen L. Brown,et al.  Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials , 2014, Radiation oncology journal.

[7]  Sung Dae Kim,et al.  Korean Red Ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264.7 macrophage cells , 2014, Journal of ginseng research.

[8]  Y. S. Shin,et al.  Protective effects of Korean red ginseng against radiation-induced apoptosis in human HaCaT keratinocytes , 2013, Journal of radiation research.

[9]  R. Ramesh,et al.  Mitogen-activated protein kinases and their role in radiation response. , 2013, Genes & cancer.

[10]  R. Kiss,et al.  Synthesis and plasma pharmacokinetics in CD‐1 mice of a 18β‐glycyrrhetinic acid derivative displaying anti‐cancer activity , 2013, The Journal of pharmacy and pharmacology.

[11]  Z. Zagórski,et al.  Ionizing Radiation: Friend or Foe of the Origins of Life? , 2012, Origins of Life and Evolution of Biospheres.

[12]  J. Ryan.  Ionizing radiation: the good, the bad, and the ugly. , 2012, The Journal of investigative dermatology.

[13]  Laurence A. Marchat,et al.  Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis , 2011, International journal of molecular sciences.

[14]  R. Hill,et al.  Investigations into the role of inflammation in normal tissue response to irradiation. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[15]  Wen-Hsieh Lo,et al.  Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. , 2011, Journal of agricultural and food chemistry.

[16]  Chao‐Lin Kuo,et al.  Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-κB pathways in TNF-α-activated endothelial cells , 2010, Acta Pharmacologica Sinica.

[17]  W. McBride,et al.  Links between Innate Immunity and Normal Tissue Radiobiology , 2010, Radiation research.

[18]  S. Lutgendorf.  Positive affect and radiation-induced inflammation: Insights into inflammatory regulation? , 2009, Brain, Behavior, and Immunity.

[19]  A. Balan,et al.  Radiation Induced Oral Mucositis , 2009, Indian journal of palliative care.

[20]  A. Hoffmann,et al.  NF‐κB signaling , 2009, Wiley interdisciplinary reviews. Systems biology and medicine.

[21]  P. Kalaiarasi,et al.  Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats. , 2009, European journal of pharmacology.

[22]  C. Fournier,et al.  Differential effects of irradiation with carbon ions and x-rays on macrophage function. , 2009, Journal of radiation research.

[23]  Hossein Hosseinzadeh,et al.  Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds , 2008, Phytotherapy research : PTR.

[24]  V. Shaposhnikova,et al.  Detection of Reactive Oxygen Species Induced by Radiation in Cells Using the Dichlorofluorescein Assay , 2007, Radiation research.

[25]  A. Hoffmann,et al.  Transcriptional regulation via the NF-κB signaling module , 2006, Oncogene.

[26]  P. Okunieff,et al.  Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis. , 2006, International journal of radiation oncology, biology, physics.

[27]  Paul Van Houtte,et al.  NF-kappaB modulation and ionizing radiation: mechanisms and future directions for cancer treatment. , 2006, Cancer letters.

[28]  闫卫平.  Radiation pneumonitis , 2004 .

[29]  A. Shah,et al.  Intracellular Localization and Preassembly of the NADPH Oxidase Complex in Cultured Endothelial Cells* , 2002, The Journal of Biological Chemistry.

[30]  Y. Hosoi,et al.  Induction of interleukin‐1β and interleukin‐6 mRNA by low doses of ionizing radiation in macrophages , 2001 .

[31]  John C. Lee,et al.  Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. , 1999, Biochemical and biophysical research communications.

[32]  C. Chen,et al.  p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. , 1999, Molecular pharmacology.

[33]  G. Haegeman,et al.  p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor* , 1998, The Journal of Biological Chemistry.

[34]  R. Davis,et al.  Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways , 1996, Journal of Molecular Medicine.

[35]  W. Fiers,et al.  The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor. , 1996, The EMBO journal.

[36]  G. Somers,et al.  THE PHARMACOLOGICAL PROPERTIES OF GLYCYRRHETINIC ACID‐A NEW ANTI‐INFLAMMATORY DRUG , 1958, The Journal of pharmacy and pharmacology.

[37]  G. Cheng,et al.  Radiation and inflammation. , 2015, Seminars in radiation oncology.

[38]  S. Akita.  Treatment of Radiation Injury. , 2014, Advances in wound care.

[39]  Dong-Hyun Kim,et al.  Anti-allergic activity of 18β-glycyrrhetinic acid-3-O-β-D-glucuronide , 2004 .