Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/β-catenin signaling pathway.

[1]  E. Brown,et al.  The calcium-sensing receptor: A promising target for prevention of colorectal cancer☆ , 2015, Biochimica et biophysica acta.

[2]  E. Brown,et al.  The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon , 2015, Molecular Cancer.

[3]  V. Vallon,et al.  Molecular Mechanisms of Calcium-sensing Receptor-mediated Calcium Signaling in the Modulation of Epithelial Ion Transport and Bicarbonate Secretion* , 2014, The Journal of Biological Chemistry.

[4]  D. Chen,et al.  The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na+/Ca2+ exchanger and increasing intracellular Ca2+ , 2014, British journal of pharmacology.

[5]  Jundong Jiao,et al.  Calcium Sensing Receptor Modulates Extracellular Calcium Entry and Proliferation via TRPC3/6 Channels in Cultured Human Mesangial Cells , 2014, PloS one.

[6]  R. Benninger,et al.  Decreasing Cx36 Gap Junction Coupling Compensates for Overactive KATP Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes , 2014, Diabetes.

[7]  E. Brown,et al.  Role of the calcium-sensing receptor in extracellular calcium homeostasis. , 2013, Best practice & research. Clinical endocrinology & metabolism.

[8]  A. Jemal,et al.  Cancer statistics, 2013 , 2013, CA: a cancer journal for clinicians.

[9]  F. Davis,et al.  Calcium Channels and Pumps in Cancer: Changes and Consequences* , 2012, The Journal of Biological Chemistry.

[10]  S. H. Young,et al.  Negative Cross-talk between Calcium-sensing Receptor and β-Catenin Signaling Systems in Colonic Epithelium* , 2011, The Journal of Biological Chemistry.

[11]  A. Galione,et al.  Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. , 2011, The Biochemical journal.

[12]  O. Gerasimenko,et al.  Aberrant Ca(2+) signalling through acidic calcium stores in pancreatic acinar cells. , 2011, Cell calcium.

[13]  N. Prevarskaya,et al.  Calcium in tumour metastasis: new roles for known actors , 2011, Nature Reviews Cancer.

[14]  Hiromu Suzuki,et al.  Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis , 2011, Modern Pathology.

[15]  R. Gomis,et al.  Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion* , 2011, The Journal of Biological Chemistry.

[16]  K. Mikoshiba,et al.  Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors , 2011, Proceedings of the National Academy of Sciences.

[17]  S. Ramamoorthy,et al.  Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells. , 2010, American journal of physiology. Cell physiology.

[18]  Christopher R Weber,et al.  Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. , 2010, Gastroenterology.

[19]  Tai C. Chen,et al.  Vitamin D for the prevention and treatment of pancreatic cancer. , 2009, World journal of gastroenterology.

[20]  I. Novak,et al.  Purinergic Receptors Stimulate Na+/Ca2+ Exchange in Pancreatic Duct Cells: Possible Role of Proteins Handling and Transporting Ca2+ , 2009, Cellular Physiology and Biochemistry.

[21]  E. Brown,et al.  The role of the calcium-sensing receptor in the development and progression of cancer. , 2009, Endocrine reviews.

[22]  Kechun Zhou,et al.  Transient receptor potential channel C3 contributes to the progression of human ovarian cancer , 2009, Oncogene.

[23]  J. Varani,et al.  Regulation of E‐cadherin and β‐catenin by Ca2+ in colon carcinoma is dependent on calcium‐sensing receptor expression and function , 2007, International journal of cancer.

[24]  Gordon B. Mills,et al.  Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity* , 2007, Journal of Biological Chemistry.

[25]  W. Willett,et al.  Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies , 2006, Cancer Epidemiology Biomarkers & Prevention.

[26]  N. Dulin,et al.  Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase* , 2006, Journal of Biological Chemistry.

[27]  E. Brown,et al.  Calcium: Extracellular calcium sensing and signalling , 2003, Nature Reviews Molecular Cell Biology.

[28]  M. Berridge,et al.  Calcium: Calcium signalling: dynamics, homeostasis and remodelling , 2003, Nature Reviews Molecular Cell Biology.

[29]  J. Kere,et al.  Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. , 2003, American journal of physiology. Cell physiology.

[30]  A. Galione,et al.  Interactions between calcium release pathways: multiple messengers and multiple stores. , 2002, Cell calcium.

[31]  Á. Kittel,et al.  Extracellular calcium sensing receptor in human pancreatic cells , 2002, Gut.

[32]  F. Wrba,et al.  Immunocytochemical Localization of the Extracellular Calcium-Sensing Receptor in Normal and Malignant Human Large Intestinal Mucosa , 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[33]  P. Squires,et al.  The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion. , 2000, Diabetes.

[34]  Xuesong Yang,et al.  Molecular and Functional Identification of a Ca2+ (Polyvalent Cation)-sensing Receptor in Rat Pancreas* , 1999, The Journal of Biological Chemistry.

[35]  M. Lipkin,et al.  Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice. , 1999, Journal of the National Cancer Institute.

[36]  De-Pei Li,et al.  Chronic Intermittent Hypobaric Hypoxia Ameliorates Ischemia/Reperfusion-Induced Calcium Overload in Heart via Na+/Ca2+ Exchanger in Developing Rats , 2014, Cellular Physiology and Biochemistry.

[37]  S. Hebert,et al.  The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. , 2009, Annual review of physiology.

[38]  N. Dulin,et al.  Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. , 2006, The Journal of biological chemistry.

[39]  J. Balsinde,et al.  Regulation and inhibition of phospholipase A2. , 1999, Annual review of pharmacology and toxicology.