A fuzzy-logic-based fault detection system for medical Internet of Nano Things

Abstract In this paper, a fuzzy-logic-based fault detection system is designed for a medical Internet of Nano Things architecture. The goal of this system is to detect the root cause and severity of the faults occurred in the in-body nanonetwork. Since nanomachines have very limited capabilities, the sampled data from the in-body nanonetwork is sent to cloud servers by means of an on-body micro-gateway. The fuzzy fault detection system was designed based on two well-known methods including Mamdani and Takagi–Sugeno–Kang (TSK) fuzzy systems. The performance of the proposed approach is evaluated on a theoretical model of medical in-body nanonetwork from the literature through in silico study. This nanonetwork includes eleven types of nanomachines which cooperate with each other within the arterial wall and interact with low-density lipoprotein (LDL), drug and signaling molecules in order to prevent the formation and development of Atherosclerosis plaques. Any fault in these nanomachines can highly take negative effect on treatment efficiency. The results of computer simulation and comparative study on 37 atherosclerosis patients demonstrate how the proposed approach could successfully detect the root cause and severity of the faults occurred in the nanonetwork.

[1]  Reza Malekian,et al.  Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications , 2016, IEEE Transactions on Communications.

[2]  Mohammad-R Akbarzadeh-T,et al.  Dynamic swarm learning for nanoparticles to control drug release function using RBF networks in atherosclerosis , 2015, 2015 The International Symposium on Artificial Intelligence and Signal Processing (AISP).

[3]  Ahmed E. Youssef,et al.  A Nano-biosensors model with optimized bio-cyber communication system based on Internet of Bio-Nano Things for thrombosis prediction , 2020, Journal of Nanoparticle Research.

[4]  Anand Nayyar,et al.  Internet of Nano Things (IoNT): Next Evolutionary Step in Nanotechnology , 2017 .

[5]  Mahdi H. Miraz,et al.  Internet of Nano-Things, Things and Everything: Future Growth Trends , 2018, Future Internet.

[6]  Xavier Hesselbach,et al.  Nano-networks communication architecture: Modeling and functions , 2018, Nano Commun. Networks.

[7]  Falko Dressler,et al.  Function Centric Nano-Networking: Addressing nano machines in a medical application scenario , 2017, Nano Commun. Networks.

[8]  Massimiliano Pierobon,et al.  Nanonetworks in Biomedical Applications. , 2019, Current drug targets.

[9]  Kambiz Vafai,et al.  Modeling of low-density lipoprotein (LDL) transport in the artery—effects of hypertension , 2006 .

[10]  Youssef Chahibi,et al.  Molecular communication for drug delivery systems: A survey , 2017, Nano Commun. Networks.

[11]  Jussi Kangasharju,et al.  Realizing the Internet of Nano Things: Challenges, Solutions, and Applications , 2013, Computer.

[12]  A. Vasilakos,et al.  Molecular Communication Among Biological Nanomachines: A Layered Architecture and Research Issues , 2014, IEEE Transactions on NanoBioscience.

[13]  Pijush Kanti Dutta Pramanik,et al.  Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges , 2020, IEEE Access.

[14]  Ian F. Akyildiz,et al.  Distributed Timely Throughput Optimal Scheduling for the Internet of Nano-Things , 2016, IEEE Internet of Things Journal.

[15]  Mohammad R. Akbarzadeh-Totonchi,et al.  Stigmergic cooperation of nanoparticles for swarm fuzzy control of low-density lipoprotein concentration in the arterial wall , 2015, Appl. Soft Comput..

[16]  Pietro Liò,et al.  Applications of molecular communications to medicine: A survey , 2016, Nano Commun. Networks.

[17]  Falko Dressler,et al.  Connecting in-body nano communication with body area networks: Challenges and opportunities of the Internet of Nano Things , 2015, Nano Commun. Networks.

[18]  Ian F. Akyildiz,et al.  The Internet of nano-things , 2010, IEEE Wireless Communications.

[19]  Murat Kuscu,et al.  Modeling convection-diffusion-reaction systems for microfluidic molecular communications with surface-based receivers in Internet of Bio-Nano Things , 2018, PloS one.

[20]  Olga Galinina,et al.  Understanding the IoT connectivity landscape: a contemporary M2M radio technology roadmap , 2015, IEEE Communications Magazine.

[21]  Ian F. Akyildiz,et al.  Nanonetworks: A new communication paradigm , 2008, Comput. Networks.

[22]  Mohammad Reza Akbarzadeh Totonchi,et al.  AUTONOMOUS DRUG-ENCAPSULATED NANOPARTICLES: TOWARDS A NOVEL NON-INVASIVE APPROACH TO PREVENT ATHEROSCLEROSIS , 2013 .

[23]  Y. Koucheryavy,et al.  The internet of Bio-Nano things , 2015, IEEE Communications Magazine.

[24]  Mohammad-R Akbarzadeh-T,et al.  Swarm learning of interval nanoparticles to estimate the drug release function in atherosclerosis , 2015, 2015 4th Iranian Joint Congress on Fuzzy and Intelligent Systems (CFIS).

[25]  Ian F. Akyildiz,et al.  Electromagnetic wireless nanosensor networks , 2010, Nano Commun. Networks.

[26]  Mohammad-R Akbarzadeh-T,et al.  Control of Low-Density Lipoprotein Concentration in the Arterial Wall by Proportional Drug-Encapsulated Nanoparticles , 2012, IEEE Transactions on NanoBioscience.

[27]  Giuseppe Piro,et al.  Beyond the smart things: Towards the definition and the performance assessment of a secure architecture for the Internet of Nano-Things , 2019, Comput. Networks.

[28]  Fadi Al-Turjman,et al.  A Cognitive Routing Protocol for Bio-Inspired Networking in the Internet of Nano-Things (IoNT) , 2020, Mob. Networks Appl..

[29]  Mufti Mahmud,et al.  An Energy Conserving Routing Scheme for Wireless Body Sensor Nanonetwork Communication , 2018, IEEE Access.

[30]  Ian F. Akyildiz,et al.  A new nanonetwork architecture using flagellated bacteria and catalytic nanomotors , 2010, IEEE Journal on Selected Areas in Communications.

[31]  Giuseppe Piro,et al.  On the design of an energy-harvesting protocol stack for Body Area Nano-NETworks , 2015, Nano Commun. Networks.

[32]  Alireza Rowhanimanesh Towards Realization of Intelligent Medical Treatment at Nanoscale by Artificial Microscopic Swarm Control Systems , 2017 .

[33]  Li-Xin Wang,et al.  A Course In Fuzzy Systems and Control , 1996 .