The effect of cimetidine and hypoxia on the gastric macromolecular glycoprotein in rat.

In an experimental study in rats, cimetidine, a potent gastric-acid inhibitor (50 mg/kg, .p.o.) reduced the macromolecular glycoprotein level of glandular stomach. The administration of cimeti­ dine at a dose of 50 mg/kg, which inhibited the gastric lesions induced by hypoxia (13% O2 for 6 hours), reduced the glandular stomach level of high molecular glycoproteins in animals receiving a low oxygen load as well as in those receiving no load. It was assumed that the reduction of macro­ molecular glycoprotein accelerated the gastric lesion induced by hypoxia load in rats and that cimeti­ dine inhibited the lesions through a process other than that of recovering the glycoprotein level in the glandular stomach.

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