Comparison of the effects of early handling and early deprivation on maternal care in the rat.

It has been reported in the rat that postnatal manipulations can induce robust and persistent effects on offspring neurobiology and behavior, mediated in part via effects on maternal care. There have, however, been few studies of the effects of postnatal manipulations on maternal care. Here, we describe and compare the effects on maternal behavior on postnatal days 1-12 of two manipulations, early handling (EH, 15-min isolation per day) and early deprivation (ED, 4-hr isolation per day), relative to our normal postnatal husbandry procedure. Maternal behavior was measured at five time points across the dark phase of the reversed L:D cycle. EH yielded an increase in arched-back nursing across several time points but did not affect any other behavior. ED stimulated a bout of maternal behavior such that licking and arched-back nursing were increased at the time of dam-litter reunion, although not at any other time point. Neither EH nor ED affected weaning weight significantly. Importantly, within-treatment variation was high relative to these between-treatment effects.

[1]  J. Day,et al.  Maternal care, hippocampal synaptogenesis and cognitive development in rats , 2000, Nature Neuroscience.

[2]  Shakti Sharma,et al.  The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat , 2000, Neuropsychopharmacology.

[3]  M. Meaney,et al.  Nongenomic transmission across generations of maternal behavior and stress responses in the rat. , 1999, Science.

[4]  E. D. de Kloet,et al.  Maternal Deprivation Effect on the Infant’s Neural Stress Markers Is Reversed by Tactile Stimulation and Feeding But Not by Suppressing Corticosterone , 1998, The Journal of Neuroscience.

[5]  J. Stern,et al.  Functions of the caudal periaqueductal gray in lactating rats: Kyphosis, lordosis, maternal aggression, and fearfulness , 1998 .

[6]  Shakti Sharma,et al.  Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Shakti Sharma,et al.  Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. , 1997, Science.

[8]  C. Nemeroff,et al.  Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. , 1996, Endocrinology.

[9]  M. Hofer Multiple regulators of ultrasonic vocalization in the infant rat , 1996, Psychoneuroendocrinology.

[10]  M. Hofer Early relationships as regulators of infant physiology and behavior , 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

[11]  M. Meaney,et al.  Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. , 1993, Brain research. Molecular brain research.

[12]  I. Weiner,et al.  From an animal model of an attentional deficit towards new insights into the pathophysiology of schizophrenia. , 1992, Journal of psychiatric research.

[13]  B. Zimmerberg,et al.  Temperature-dependent effects of maternal separation on growth, activity, and amphetamine sensitivity in the rat. , 1992, Developmental psychobiology.

[14]  J. Stern,et al.  Ventral somatosensory determinants of nursing behavior in Norway rats. I. Effects of variations in the quality and quantity of pup stimuli , 1990, Physiology & Behavior.

[15]  R. Sapolsky,et al.  Effect of neonatal handling on age-related impairments associated with the hippocampus. , 1988, Science.

[16]  R. Lubow,et al.  The effects of early handling on latent inhibition in male and female rats. , 1985, Developmental psychobiology.

[17]  R. Ader,et al.  Behavior of lactating rats in a dual-chambered maternity cage. , 1974, Hormones and behavior.

[18]  D. Williams,et al.  Changes in licking behaviour of rat mother following handling of young , 1974 .

[19]  E. Howard,et al.  Statistical procedure in developmental studies on species with multiple offspring. , 1973, Developmental psychobiology.

[20]  S. Levine,et al.  Pituitary-adrenal activity in the postpartum rat in the absence of suckling stimulation. , 1972, Hormones and behavior.

[21]  Robert Ader,et al.  Continuous recording of maternal behaviour in Rattus norvegicus , 1969 .

[22]  V. Denenberg,et al.  Test of the monotonicity hypothesis concerning infantile stimulation and emotional reactivity. , 1967, Journal of comparative and physiological psychology.

[23]  S. Levine Stimulation in infancy. , 1960, Scientific American.

[24]  Shakti Sharma,et al.  Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. , 1996, Developmental neuroscience.

[25]  J. Stern Somatosensation and Maternal Care in Norway Rats , 1996 .

[26]  J. Squire,et al.  Maternal behavior of SHR rats and its relationship to offspring blood pressures. , 1989, Developmental psychobiology.

[27]  J. Stern Maternal Behavior: Sensory, Hormonal, and Neural Determinants , 1989 .

[28]  W. P. Smotherman,et al.  Maternal Mediation of Early Experience , 1980 .

[29]  V. Denenberg Chapter 5 – Assessing the Effects of Early Experience1 , 1977 .

[30]  R. Bell,et al.  Infantile stimulation and ultrasonic signaling: a possible mediator of early handling phenomena. , 1971, Developmental psychobiology.

[31]  Victor H. Denenberg,et al.  Physiological and behavioral effects of infantile stimulation , 1967 .