Methods for air cleaning and protection of building occupants from airborne pathogens

Abstract This article aims to draw the attention of the scientific community towards the elevated risks of airborne transmission of diseases and the associated risks of epidemics or pandemics. The complexity of the problem and the need for multidisciplinary research is highlighted. The airborne route of transmission, i.e. the generation of pathogen laden droplets originating in the respiratory tract of an infected individual, the survivability of the pathogens, their dispersal indoors and their transfer to a healthy person are reviewed. The advantages and the drawbacks of air dilution, filtration, ultraviolet germicidal irradiation (UVGI), photocatalytic oxidation (PCO), plasmacluster ions and other technologies for air disinfection and purification from pathogens are analyzed with respect to currently used air distribution principles. The importance of indoor air characteristics, such as temperature, relative humidity and velocity for the efficiency of each method is analyzed, taking into consideration the nature of the pathogens themselves. The applicability of the cleaning methods to the different types of total volume air distribution used at present indoors, i.e. mixing, displacement and underfloor ventilation, as well as advanced air distribution techniques (such as personalized ventilation) is discussed.

[1]  S F Bloomfield,et al.  Spread and prevention of some common viral infections in community facilities and domestic homes , 2001, Journal of applied microbiology.

[2]  J. Phair,et al.  Airborne Contagion and Air Hygiene , 1955 .

[3]  M. First,et al.  Guidelines for the application of upper-room ultraviolet germicidal irradiation for preventing transmission of airborne contagion -- Part 1: Basic principles , 1999 .

[4]  William P. Bahnfleth,et al.  Airborne-microbe filtration in indoor environments , 2002 .

[5]  Raymond Tellier,et al.  Review of Aerosol Transmission of Influenza A Virus , 2006, Emerging infectious diseases.

[6]  B. Moudgil,et al.  Photocatalytic Disinfection with Titanium Dioxide Coated Multi-Wall Carbon Nanotubes , 2005 .

[7]  Arsen Krikor Melikov,et al.  Personalized ventilation: air terminal devices with high efficiency , 2003 .

[8]  Shinhao Yang,et al.  The size and concentration of droplets generated by coughing in human subjects. , 2007, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[9]  R. Ehrlich,et al.  Effect of Relative Humidity and Temperature on Airborne Venezuelan Equine Encephalitis Virus , 1971, Applied microbiology.

[10]  O. Lidwell Aerial dispersal of micro-organisms from the human respiratory tract. , 1974, Society for Applied Bacteriology symposium series.

[11]  N. Hahon,et al.  Assessment of aerosol stability of yellow fever virus by fluorescent-cell counting. , 1968, Applied microbiology.

[12]  W. Kowalski,et al.  UVGI design basics for air and surface disinfection , 2000 .

[13]  James A Hanley,et al.  Effect of ultraviolet germicidal lights installed in office ventilation systems on workers' health and wellbeing: double-blind multiple crossover trial , 2003, The Lancet.

[14]  J. H. Hemmes,et al.  Virus Survival as a Seasonal Factor in Influenza and Poliomyelitis , 1960, Nature.

[15]  M. M. Jensen INACTIVATION OF AIRBORNE VIRUSES BY ULTRAVIOLET IRRADIATION. , 1964, Applied microbiology.

[16]  X. Xie,et al.  How far respiratory droplets move in indoor environments , 2006 .

[17]  G B Knudson,et al.  Photoreactivation of ultraviolet-irradiated, plasmid-bearing, and plasmid-free strains of Bacillus anthracis , 1986, Applied and environmental microbiology.

[18]  Mark Hernandez,et al.  Effects of Relative Humidity on the Ultraviolet Induced Inactivation of Airborne Bacteria , 2001 .

[19]  A. Melikov Personalized ventilation. , 2004, Indoor air.

[20]  K. Winkler,et al.  Survival of Measles Virus in Air , 1964, Nature.

[21]  R. Loudon,et al.  Droplet expulsion from the respiratory tract. , 1967, The American review of respiratory disease.

[22]  Melvin W. First,et al.  Guidelines for the Application of Upper-Room Ultraviolet Germicidal Irradiation for Preventing Transmission of Airborne Contagion—Part II: Design and Operation Guidance , 1999 .

[23]  Arsen Krikor Melikov,et al.  Distribution of contaminants in the occupied zone of a room with personalized and displacement ventilation , 2004 .

[24]  F. Laforce Airborne infections and modern building technology , 1986 .

[25]  Elisabeth Mundt,et al.  Non-buoyant pollutant sources and particles in displacement ventilation , 2001 .

[26]  S. Block,et al.  Disinfection, sterilization, and preservation , 1977 .

[27]  P V Nielsen,et al.  Role of ventilation in airborne transmission of infectious agents in the built environment - a multidisciplinary systematic review. , 2007, Indoor air.

[28]  C. Liao,et al.  Predictive models of control strategies involved in containing indoor airborne infections. , 2006, Indoor air.

[29]  G. Bai,et al.  Worldwide Emergence of Extensively Drug-resistant Tuberculosis , 2007, Emerging infectious diseases.

[30]  William P. Bahnfleth,et al.  Airborne respiratory diseases and mechanical systems for control of microbes , 1998 .

[31]  S. Sattar,et al.  Effect of relative humidity on the airborne survival of rhinovirus-14. , 1985, Canadian journal of microbiology.

[32]  John Steel,et al.  Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature , 2007, PLoS pathogens.

[33]  R. Qualls,et al.  UV inactivation of pathogenic and indicator microorganisms , 1985, Applied and environmental microbiology.

[34]  William P. Bahnfleth,et al.  Immune-building technology and bioterrorism defense , 2003 .

[35]  S. Sattar,et al.  Survival characteristics of airborne human coronavirus 229E. , 1985, The Journal of general virology.

[36]  Peter V. Nielsen,et al.  Personal Exposure Between People in a Room Ventilated by Textile Terminals—with and without Personalized Ventilation , 2007 .

[37]  J. Derbyshire,et al.  Effect of temperature, relative humidity and medium on the aerosol stability of infectious bovine rhinotracheitis virus. , 1979, Canadian journal of comparative medicine : Revue canadienne de medecine comparee.

[38]  R. Riley,et al.  Ultraviolet susceptibility of BCG and virulent tubercle bacilli. , 1976, The American review of respiratory disease.

[39]  R. L. Jensen,et al.  Personal Exposure Between People in a Mixing Ventilated Room , 2001 .

[40]  Arsen Krikor Melikov,et al.  Air Quality and Thermal Comfort in an Office with Underfloor, Mixing and Displacement Ventilation , 2006 .

[41]  D. Milton,et al.  Risk of indoor airborne infection transmission estimated from carbon dioxide concentration. , 2003, Indoor air.

[42]  F. Allard,et al.  Experimental Study of Fine Particle Deposition in Rooms , 2006 .

[43]  M. Artenstein,et al.  Aerosol Stability of Three Acute Respiratory Disease Viruses , 1967, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[44]  D. Y. Goswami,et al.  Enhanced photocatalytic disinfection of indoor air , 2006 .

[45]  R. Riley,et al.  Room air disinfection by ultraviolet irradiation of upper air. Further analysis of convective air exchange. , 1971, Archives of environmental health.

[46]  Mark Hernandez,et al.  Photoreactivation in AirborneMycobacterium parafortuitum , 2001, Applied and Environmental Microbiology.

[47]  H. G. Jenkins,et al.  Applications of Germicidal, Erythemal and Infrared Energy , 1948, Nature.

[48]  C. G. Loosli,et al.  Experimental Air-Borne Influenza Infection. I. Influence of Humidity on Survival of Virus in Air.∗ , 1943 .

[49]  T. Riley,et al.  Antimicrobial activity of essential oils and other plant extracts , 1999, Journal of applied microbiology.

[50]  William P. Bahnfleth,et al.  Effective UVGI System Design Through Improved Modeling , 2000 .

[51]  C. Gerba,et al.  Reduction of faecal coliform, coliform and heterotrophic plate count bacteria in the household kitchen and bathroom by disinfection with hypochlorite cleaners , 1998, Journal of applied microbiology.

[52]  G Morin,et al.  Medical Microbiology , 1940, Nature.

[53]  A. Melikov,et al.  Protection of Occupants from Exhaled Infectious Agents and Floor Material Emissions in Rooms with Personalized and Underfloor Ventilation , 2007 .

[54]  J. Siak,et al.  Survival of coxsackievirus B3 under diverse environmental conditions , 1979, Applied and environmental microbiology.

[55]  P V Nielsen,et al.  Dispersion of exhaled droplet nuclei in a two-bed hospital ward with three different ventilation systems. , 2006, Indoor air.

[56]  C. Chao,et al.  Effect of changing the air distribution system on the dispersion of droplet phase aerosols in an enclosure , 2005 .

[57]  Cover Sheet DROPLET FATE IN INDOOR ENVIRONMENTS , OR CAN WE PREVENT THE SPREAD OF INFECTION ? , 2007 .

[58]  Mark Hernandez,et al.  Ultraviolet germicidal irradiation inactivation of airborne fungal spores and bacteria in upper-room air and HVAC in-duct configurations , 2007 .

[59]  A. Hubbard,et al.  Toward Understanding the Risk of Secondary Airborne Infection: Emission of Respirable Pathogens , 2005, Journal of occupational and environmental hygiene.

[60]  A. Melikov,et al.  Impact of airflow interaction on inhaled air quality and transport of contaminants in rooms with personalized and total volume ventilation , 2003 .

[61]  M. First,et al.  The characterization of upper-room ultraviolet germicidal irradiation in inactivating airborne microorganisms. , 2002, Environmental health perspectives.

[62]  Jennifer Fiegel,et al.  Airborne infectious disease and the suppression of pulmonary bioaerosols , 2006, Drug Discovery Today.

[63]  G. Harper,et al.  Airborne micro-organisms: survival tests with four viruses , 1961, Epidemiology and Infection.

[64]  S. Inouye Comparative study of antimicrobial and cytotoxic effects of selected essential oils by gaseous and solution contacts , 2003 .

[65]  L. Buttolph Ultraviolet Air Disinfection in the Theater , 1948 .

[66]  W. F. Wells,et al.  On Air-borne Infection. Study II. Droplets and Droplet Nuclei. , 1934 .

[67]  Madhumita B. Ray,et al.  Tio2 Mediated Photocatalytic Inactivation of Gram-Positive And Gram- Negative Bacteria Using Fluorescent Light , 2006 .

[68]  Hao Jiang,et al.  Bed with Integrated Personalized Ventilation for Minimizing Cross Infection , 2007 .

[69]  Jianlei Niu,et al.  Experimental study on a chair-based personalized ventilation system , 2007 .

[70]  R. Riley,et al.  Convection, air mixing, and ultraviolet air disinfection in rooms. , 1971, Archives of environmental health.

[71]  Magnus Mattsson,et al.  Displacement Ventilation: effects of movement and exhalation , 1997 .

[72]  M. Möritz,et al.  Capability of air filters to retain airborne bacteria and molds in heating, ventilating and air-conditioning (HVAC) systems. , 2001, International journal of hygiene and environmental health.

[73]  Mark Hernandez,et al.  Impact of environmental factors on efficacy of upper-room air ultraviolet germicidal irradiation for inactivating airborne mycobacteria. , 2005, Environmental science & technology.

[74]  R. Riley,et al.  Room air disinfection by ultraviolet irradiation of upper air. Air mixing and germicidal effectiveness. , 1971, Archives of environmental health.