论文信息 - Synthesis of two non-peptidyl GnRH receptor antagonists via [14C]carbonylation

Synthesis of two non-peptidyl GnRH receptor antagonists via [14C]carbonylation

In support of a program to develop a new gonadotropin releasing hormone (GnRH) receptor antagonist, two 14C labelled candidate tracers, 14C-1 and 14C-2, were synthesized for utilization in metabolism studies. A slight modification of the Medicinal Chemistry route for the synthesis of the antagonists provided iodide 4. Palladium (0) catalyzed [14C]carbonylation of 4 proceeded in good chemical yield to afford acid 14C-3 which served as a common precursor to 14C-1 and 14C-2. Copyright © 2003 John Wiley & Sons, Ltd.

R. DeVita | D. Dean | D. Melillo | C. Elmore

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