The RAG proteins in V(D)J recombination: more than just a nuclease.
暂无分享,去创建一个
[1] J. Hansen,et al. The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis. , 1995, Immunogenetics.
[2] D. Schatz,et al. Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2. , 1997, Journal of immunology.
[3] S. Lewis,et al. Postcleavage Sequence Specificity in V(D)J Recombination , 2000, Molecular and Cellular Biology.
[4] D. Ramsden,et al. Cell-free V(D)J recombination , 1997, Nature.
[5] A. Villa,et al. The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. , 1999, Molecular cell.
[6] K. Schwarz,et al. RAG and RAG defects. , 1999, Current opinion in immunology.
[7] P. Karran,et al. DNA double strand break repair in mammalian cells. , 2000, Current opinion in genetics & development.
[8] Wei Yang,et al. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. , 1999, Genes & development.
[9] D. Schatz,et al. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. , 1990, Science.
[10] Marjorie A. Oettinger,et al. Functional Analysis of Coordinated Cleavage in V(D)J Recombination , 1998, Molecular and Cellular Biology.
[11] A. Villa,et al. N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[12] Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[13] G. Barrowclough,et al. Basal divergences in birds and the phylogenetic utility of the nuclear RAG-1 gene. , 1999, Molecular phylogenetics and evolution.
[14] J E Hesse,et al. Expression and V(D)J recombination activity of mutated RAG-1 proteins. , 1994, Nucleic acids research.
[15] D. Roth,et al. Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro. , 2001, Molecular cell.
[16] J. Mornon,et al. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis , 1998, Cellular and Molecular Life Sciences CMLS.
[17] D. Schatz,et al. Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes , 2000, Nature.
[18] D. Baltimore,et al. Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[19] D. Roth,et al. Intermolecular V(D)J recombination is prohibited specifically at the joining step. , 1999, Molecular cell.
[20] T. Paull,et al. A mechanistic basis for Mre11-directed DNA joining at microhomologies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[21] R. Reeves,et al. High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. , 1996, Progress in nucleic acid research and molecular biology.
[22] D. Roth,et al. Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends. , 1999, Molecular immunology.
[23] R. Plasterk. V (D)J recombination: Ragtime jumping , 1998, Nature.
[24] M. Goodman,et al. Error-Prone Candidates Vie for Somatic Mutation , 2000, The Journal of experimental medicine.
[25] K. Mizuuchi,et al. Mu Transpositional Recombination: Donor DNA Cleavage and Strand Transfer in trans by the Mu Transposase , 1996, Cell.
[26] S. Lewis,et al. Evolution of the recombination signal sequences in the Ig heavy-chain variable region locus of mammals. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[27] Robert B. West,et al. The RAG-HMG1 Complex Enforces the 12/23 Rule of V(D)J Recombination Specifically at the Double-Hairpin Formation Step , 1998, Molecular and Cellular Biology.
[28] A. Villa,et al. Intrathymic restriction and peripheral expansion of the T-cell repertoire in Omenn syndrome. , 1999, Blood.
[29] M. Lieber,et al. Coding end sequence can markedly affect the initiation of V(D)J recombination. , 1993, Genes & development.
[30] Vassilis Aidinis,et al. The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2 , 1999, Molecular and Cellular Biology.
[31] Christina A. Cuomo,et al. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences , 1996, Molecular and cellular biology.
[32] E. Brooks,et al. Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies , 2000, Molecular and Cellular Biology.
[33] N. Harindranath,et al. Recombination activating genes-1 and -2 of the rabbit: cloning and characterization of germline and expressed genes. , 1993, Molecular immunology.
[34] F. Alt,et al. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. , 1998, Immunity.
[35] M. Lieber,et al. The Nicking Step in V(D)J Recombination Is Independent of Synapsis: Implications for the Immune Repertoire , 2000, Molecular and Cellular Biology.
[36] M. Gellert,et al. Novel strand exchanges in V(D)J recombination , 1988, Cell.
[37] David G. Schatz,et al. Initiation of V(D)J recombination in vitro obeying the 12/23 rule , 1996, Nature.
[38] J. Marchalonis,et al. Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[39] M. Oettinger,et al. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect , 1995, Science.
[40] J. Cowan,et al. Metal Activation of Enzymes in Nucleic Acid Biochemistry. , 1998, Chemical reviews.
[41] Howard T. Petrie,et al. Genetic Modulation of T Cell Receptor Gene Segment Usage during Somatic Recombination , 2000, The Journal of experimental medicine.
[42] D. Ramsden,et al. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. , 1996, The EMBO journal.
[43] D. Schatz,et al. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. , 2000, Annual review of immunology.
[44] Sandro Santagata,et al. Partial V(D)J Recombination Activity Leads to Omenn Syndrome , 1998, Cell.
[45] D. Franco,et al. Activation of V(D)J Recombination Induces the Formation of Interlocus Joints and Hybrid Joints in scid Pre-B-Cell Lines , 2000, Molecular and Cellular Biology.
[46] S. Desiderio,et al. V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. , 1998, Immunity.
[47] S. Kirch,et al. Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly , 1998, The EMBO journal.
[48] R. Miller,et al. Recombination activating gene-1 of the opossum Monodelphis domestica , 1997, Immunogenetics.
[49] M. Nussenzweig,et al. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins. , 1998, Molecular cell.
[50] D. Ramsden,et al. Initiation of V(D)J recombination in a cell-free system , 1995, Cell.
[51] J. Danska,et al. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. , 1996, Genes & development.
[52] S. Lewis,et al. Cryptic signals and the fidelity of V(D)J joining , 1997, Molecular and cellular biology.
[53] M. Oettinger. V(D)J recombination: on the cutting edge. , 1999, Current opinion in cell biology.
[54] David G. Schatz,et al. Detection of RAG Protein-V(D)J Recombination Signal Interactions Near the Site of DNA Cleavage by UV Cross-Linking , 1999, Molecular and Cellular Biology.
[55] K. Mizuuchi,et al. A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration , 1997, The EMBO journal.
[56] D. Schatz,et al. A zinc-binding domain involved in the dimerization of RAG1. , 1996, Journal of molecular biology.
[57] D. Schatz,et al. A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity , 1997, Molecular and cellular biology.
[58] D. V. van Gent,et al. Stimulation of V(D)J cleavage by high mobility group proteins , 1997, The EMBO journal.
[59] Eugenia Spanopoulou,et al. RAG1 Mediates Signal Sequence Recognition and Recruitment of RAG2 in V(D)J Recombination , 1996, Cell.
[60] D. Schatz,et al. Mechanism of V(D)J recombination. , 1996, Current opinion in immunology.
[61] X. Mo,et al. RAG1 and RAG2 Cooperate in Specific Binding to the Recombination Signal Sequence in Vitro * , 1999, The Journal of Biological Chemistry.
[62] D. Ramsden,et al. Formation and resolution of double-strand break intermediates in V(D)J rearrangement. , 1995, Genes & development.
[63] U. Storb,et al. The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences , 1997, Molecular and cellular biology.
[64] D. Roth,et al. Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. , 1999, Genes & development.
[65] M. Gellert,et al. RAG1/2-Mediated Resolution of Transposition Intermediates Two Pathways and Possible Consequences , 2000, Cell.
[66] Dale A Ramsden,et al. The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination , 1996, Cell.
[67] L. Steiner,et al. Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish , 1997, Immunogenetics.
[68] M. Gellert. Recent advances in understanding V(D)J recombination. , 1997, Advances in immunology.
[69] V Aidinis,et al. The Effect of Me2+ Cofactors at the Initial Stages of V(D)J Recombination* , 1998, The Journal of Biological Chemistry.
[70] Christina A. Cuomo,et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps , 1995, Cell.
[71] A. Kenter. The Liaison of Isotype Class Switch and Mismatch Repair , 1999, The Journal of experimental medicine.
[72] M. Lieber,et al. Mechanistic Basis for Coding End Sequence Effects in the Initiation of V(D)J Recombination , 1999, Molecular and Cellular Biology.
[73] T. Honjo,et al. Unique and unprecedented recombination mechanisms in class switching. , 2000, Current Opinion in Immunology.
[74] D. Roth,et al. Roles of the “Dispensable” Portions of RAG-1 and RAG-2 in V(D)J Recombination , 1999, Molecular and Cellular Biology.
[75] Paddy Tigme. Immunoglobulin Genes. 2nd edn , 1997 .
[76] D. Roth,et al. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination. , 2001, Molecular cell.
[77] S. Brenner,et al. Characterization of the recombinase activating gene-1 and 2 locus in the Japanese pufferfish, Fugu rubripes. , 2000, Gene.
[78] J. Hansen,et al. Recombination-activating genes, transposition, and the lymphoid-specific combinatorial immune system: a common evolutionary connection. , 2000, Current topics in microbiology and immunology.
[79] X. Mo,et al. A RAG1 and RAG2 Tetramer Complex Is Active in Cleavage in V(D)J Recombination , 1999, Molecular and Cellular Biology.
[80] X. Mo,et al. A C-Terminal Region of RAG1 Contacts the Coding DNA during V(D)J Recombination , 2001, Molecular and Cellular Biology.
[81] M. Gellert,et al. A Stable RAG1–RAG2–DNA Complex That Is Active in V(D)J Cleavage , 1997, Cell.
[82] C. Cuomo,et al. Analysis of regions of RAG-2 important for V(D)J recombination. , 1994, Nucleic acids research.
[83] P. Swanson. The DDE Motif in RAG-1 Is Contributed intrans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination , 2001, Molecular and Cellular Biology.
[84] M. Gellert,et al. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. , 1998, Molecular cell.
[85] F. Alt,et al. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule , 2000, Nature.
[86] D. Roth,et al. Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double‐strand breaks , 1997, The EMBO journal.
[87] M. Goodman,et al. Sloppier copier DNA polymerases involved in genome repair. , 2000, Current opinion in genetics & development.
[88] David G. Schatz,et al. DNA Hairpin Opening Mediated by the RAG1 and RAG2 Proteins , 1999, Molecular and Cellular Biology.
[89] B. Nadel,et al. Nucleotide deletion and P addition in V(D)J recombination: a determinant role of the coding-end sequence , 1997, Molecular and cellular biology.
[90] D. Baltimore,et al. Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. , 1997, Immunity.
[91] D. C. Dias,et al. Definition of Minimal Domains of Interaction Within the Recombination-Activating Genes 1 and 2 Recombinase Complex1 , 2000, The Journal of Immunology.
[92] J E Hesse,et al. Definition of a core region of RAG-2 that is functional in V(D)J recombination. , 1994, Nucleic acids research.
[93] S. Noggle,et al. A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1. , 2000, Nucleic acids research.
[94] L. Steiner,et al. Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopus laevis. , 1993, Journal of immunology.
[95] K. Rajewsky,et al. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. , 2000, Immunity.
[96] S. Tonegawa,et al. Somatic generation of antibody diversity. , 1976, Nature.
[97] F. Alt,et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation , 1995, Cell.
[98] Joseph E. Coleman,et al. Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster , 1997, Nature Structural Biology.
[99] R. S. Harris,et al. Somatic hypermutation and the three R's: repair, replication and recombination. , 1999, Mutation research.
[100] Michael R. Lieber,et al. A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences. , 1997, Nucleic acids research.
[101] T. Paull,et al. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. , 1998, Molecular cell.
[102] S. Desiderio,et al. RAG-2 Promotes Heptamer Occupancy by RAG-1 in the Assembly of a V(D)J Initiation Complex , 1999, Molecular and Cellular Biology.
[103] D. Schatz,et al. Intermolecular V(D)J Recombination* , 2000, The Journal of Biological Chemistry.
[104] Gillian E. Wu,et al. The Old and the Restless , 2000, The Journal of experimental medicine.
[105] Marjorie A. Oettinger,et al. Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences , 1998, Molecular and Cellular Biology.
[106] Thomas Ried,et al. Response to RAG-mediated V(D)J cleavage by NBS1 and γ-H2AX , 2000 .
[107] S. M. Lewis,et al. Cutting and closing without recombination in V(D)J joining. , 1991, The EMBO journal.
[108] S. Lewis,et al. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. , 1994, Advances in immunology.
[109] M. Lieber,et al. V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites , 1993, Molecular and cellular biology.
[110] D. Roth,et al. Characterization of broken DNA molecules associated with V(D)J recombination. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[111] D. Schatz,et al. RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination , 1997, Cell.
[112] Sandro Santagata,et al. The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination , 1996, Cell.
[113] J. Danska,et al. Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors , 2001, Molecular and Cellular Biology.
[114] P. Jeggo,et al. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. , 1998, Immunity.
[115] M. Nussenzweig,et al. V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins , 1997, The Journal of experimental medicine.
[116] K. Mizuuchi,et al. Transpositional recombination: mechanistic insights from studies of mu and other elements. , 1992, Annual review of biochemistry.
[117] M. Schlissel,et al. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. , 1993, Genes & development.
[118] D. Roth,et al. Conditional RAG-1 Mutants Block the Hairpin Formation Step of V(D)J Recombination , 2001, Molecular and Cellular Biology.
[119] David G. Schatz,et al. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system , 1998, Nature.
[120] M. Gellert,et al. DNA Transposition by the RAG1 and RAG2 Proteins A Possible Source of Oncogenic Translocations , 1998, Cell.
[121] T. Baker,et al. The Interwoven Architecture of the Mu Transposase Couples DNA Synapsis to Catalysis , 1996, Cell.
[122] M. Lieber. The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes , 1999, Genes to cells : devoted to molecular & cellular mechanisms.
[123] D. V. van Gent,et al. RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition. , 1995, Genes & development.
[124] G. Chu,et al. The end-joining reaction in V(D)J recombination. , 1997, Seminars in immunology.
[125] M. Lieber,et al. Antigen receptor gene rearrangement. , 1998, Current opinion in immunology.
[126] D. Roth,et al. VDJ Recombination A Transposase Goes to Work , 1998, Cell.
[127] S. Desiderio,et al. RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution , 1997, Molecular and Cellular Biology.
[128] S. Lewis,et al. P Nucleotides in V(D)J Recombination: A Fine-Structure Analysis , 1993, Molecular and cellular biology.
[129] D. Schatz,et al. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. , 2000, Molecular cell.
[130] A. Segall,et al. Characterization of a mutation of bacteriophage lambda integrase. Putative role in core binding and strand exchange for a conserved residue. , 2000, The Journal of biological chemistry.
[131] B. Corneo,et al. Three-dimensional Clustering of Human RAG2 Gene Mutations in Severe Combined Immune Deficiency* , 2000, The Journal of Biological Chemistry.
[132] H. Sakano,et al. The DNA-bending protein, HMG1, is required for correct cleavage of 23 bp recombination signal sequences by recombination activating gene proteins in vitro. , 2000, International immunology.
[133] David Baltimore,et al. The V(D)J recombination activating gene, RAG-1 , 1989, Cell.
[134] D. V. van Gent,et al. Rejoining of DNA by the RAG1 and RAG2 proteins. , 1998, Science.