SLOW PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS AND HEPATITIS C VIRUS DISEASE IN A COHORT OF COINFECTED CHILDREN

We carried out a retrospective study to determine the evolution of 23 vertically HIV-1/HCV coinfected children and 30 vertically HIV-1 infected children (control group). Six out of 23 HIV-1/HCV coinfected children developed AIDS versus 20 out of 30 HIV-1 children (P < 0.05). HIV-1/HCV children had a good evolution in relation to CD4+ and HIV-RNA viral load. They presented higher CD8+ counts than HIV-1 children during long periods, and slower progression of HCV liver disease.

[1]  M. Muñoz-Fernández,et al.  Clinical outcomes improve with highly active antiretroviral therapy in vertically HIV type-1-infected children. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  A. Landay,et al.  Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells. , 2006, The Journal of infectious diseases.

[3]  F. Farina,et al.  Longitudinal Long-term Follow-up Study of Children with Vertically Acquired Hepatitis C Virus Infection , 2006, The Journal of international medical research.

[4]  M. Newell,et al.  Vertically acquired paediatric coinfection with HIV and hepatitis C virus. , 2006, The Lancet. Infectious diseases.

[5]  A. Mocroft,et al.  Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. , 2005, The Journal of infectious diseases.

[6]  J. Lindsey,et al.  Hepatitis C prevalence in children with perinatal human immunodeficiency virus infection enrolled in a long-term follow-up protocol. , 2004, Archives of pediatrics & adolescent medicine.

[7]  V. Soriano,et al.  Impact of Chronic Hepatitis C on HIV-1 Disease Progression , 2004, HIV clinical trials.

[8]  R. Roldán,et al.  Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  Richard D Moore,et al.  Hepatitis C and progression of HIV disease. , 2002, JAMA.

[10]  S. Belle,et al.  Impact of human immunodeficiency virus infection on progression to end-stage liver disease in individuals with hemophilia and hepatitis C virus infection. , 2001, The Journal of infectious diseases.

[11]  M. Battegay,et al.  Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study , 2000, The Lancet.

[12]  C. Giaquinto,et al.  Current evidence for the use of paediatric antiretroviral therapy – a PENTA analysis , 2000, European Journal of Pediatrics.

[13]  D. Levy,et al.  Surveillance for waterborne-disease outbreaks--United States, 1995-1996. , 1998, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[14]  W. Borkowsky,et al.  Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women. , 1998, The Journal of infectious diseases.

[15]  P. D’argenio,et al.  Mother to infant transmission of coinfection by human immunodeficiency virus and hepatitis C virus: prevalence and clinical manifestations , 1997, Archives of Virology.