[Acute kidney injury].

New guidelines of the "Kidney Disease: Improving Global Outcome" (KDIGO) working group standardize the definition of acute kidney injury (AKI) and acute kidney disease (AKD) allowing the assessment of prognosis and efficacy of prophylactic and therapeutic measures in different patient cohorts. The degree of severity and the duration of acute kidney injury are critical factors for the development of chronic kidney disease and mortality. The achievement of optimal fluid volumes is a cornerstone in the treatment during the early phase of AKI, while volume overload should be avoided in the late phase of established AKI. Recently employed biomarkers are promising for the early detection and prognosis of AKI, but cannot yet be used as routine tests. Microscopic urinalysis, a very old and cost-effective diagnostic measure, provides valuable informations about the severity and the course of AKI.

[1]  J. Bonventre,et al.  Acute renal failure. , 2018, The New England journal of medicine.

[2]  J. Kellum,et al.  N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. , 2013, Annals of emergency medicine.

[3]  I. Koulouridis,et al.  World incidence of AKI: a meta-analysis. , 2013, Clinical journal of the American Society of Nephrology : CJASN.

[4]  V. Jha,et al.  Community-acquired acute kidney injury in tropical countries , 2013, Nature Reviews Nephrology.

[5]  J. Kellum,et al.  Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1) , 2013, Critical Care.

[6]  Sangdun Choi,et al.  Negative regulatory approaches to the attenuation of Toll-like receptor signaling , 2013, Experimental & Molecular Medicine.

[7]  W. van Biesen,et al.  Urinary and serum biomarkers for the diagnosis of acute kidney injury: an in-depth review of the literature. , 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[8]  Lin Sun,et al.  Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology , 2012, Kidney international.

[9]  A. Colombo,et al.  Impact of a High Loading Dose of Atorvastatin on Contrast-Induced Acute Kidney Injury , 2012, Circulation.

[10]  Mahboob Rahman,et al.  Acute kidney injury: a guide to diagnosis and management. , 2012, American family physician.

[11]  Yunchao Su,et al.  Autophagy in proximal tubules protects against acute kidney injury , 2012, Kidney international.

[12]  G. Biondi-Zoccai,et al.  Fenoldopam and acute renal failure in cardiac surgery: a meta-analysis of randomized placebo-controlled trials. , 2012, Journal of cardiothoracic and vascular anesthesia.

[13]  M. Kuhn.  Endothelial actions of atrial and B‐type natriuretic peptides , 2012, British journal of pharmacology.

[14]  A. Levin,et al.  Acute kidney injury and CKD: chicken or egg? , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[15]  Chirag R Parikh,et al.  Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. , 2012, Kidney international.

[16]  R. Bellomo,et al.  Techniques of Extracorporeal Cytokine Removal: A Systematic Review of the Literature , 2012, Blood Purification.

[17]  J. Lopes,et al.  The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review , 2012, Clinical kidney journal.

[18]  L. Chawla.  Acute kidney injury leading to chronic kidney disease and long-term outcomes of acute kidney injury: the best opportunity to mitigate acute kidney injury? , 2011, Contributions to nephrology.

[19]  C. Ince,et al.  The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. , 2011, Contributions to nephrology.

[20]  M. Joannidis,et al.  Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study , 2011, Critical care.

[21]  A. Agarwal,et al.  Sepsis and acute kidney injury. , 2011, Journal of the American Society of Nephrology : JASN.

[22]  R. Vanholder,et al.  How to use biomarkers efficiently in acute kidney injury. , 2011, Kidney international.

[23]  R. Rosenthal,et al.  The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. , 2010, Kidney international.

[24]  T. Feldkamp,et al.  Einsatz neuer renaler Biomarker zur Früherkennung eines akuten Nierenversagens – pro , 2010 .

[25]  K. Polderman,et al.  An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine. , 2010, American journal of respiratory and critical care medicine.

[26]  Hui Geng,et al.  Acute kidney injury: a springboard for progression in chronic kidney disease. , 2010, American journal of physiology. Renal physiology.

[27]  S. Coca.  Long-term outcomes of acute kidney injury , 2010, Current opinion in nephrology and hypertension.

[28]  M. Perazella,et al.  Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients. , 2010, Clinical journal of the American Society of Nephrology : CJASN.

[29]  Jean-Philippe Lafrance,et al.  Acute kidney injury associates with increased long-term mortality. , 2010, Journal of the American Society of Nephrology : JASN.

[30]  Robert J. Anderson,et al.  Acute kidney injury in the intensive care unit: An update and primer for the intensivist , 2010, Critical care medicine.

[31]  M. Rosner,et al.  Acute kidney injury. , 2009, Current drug targets.

[32]  Himanshu Kumar,et al.  Toll-like receptors and innate immunity. , 2009, Biochemical and biophysical research communications.

[33]  E. Gosmanova,et al.  Application of ultrasound in nephrology practice. , 2009, Advances in chronic kidney disease.

[34]  Jonathan Himmelfarb,et al.  Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. , 2009, Kidney international.

[35]  T. Wieland,et al.  The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice. , 2009, The Journal of clinical investigation.

[36]  Joshua A. Doherty,et al.  The importance of fluid management in acute lung injury secondary to septic shock. , 2009, Chest.

[37]  Amit X Garg,et al.  Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. , 2009, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[38]  Z. Dong,et al.  Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. , 2009, The Journal of clinical investigation.

[39]  S. Bagshaw,et al.  Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy , 2009, Intensive Care Medicine.

[40]  R. Inagi.  Endoplasmic Reticulum Stress in the Kidney as a Novel Mediator of Kidney Injury , 2009, Nephron Experimental Nephrology.

[41]  E. Dennis,et al.  Phospholipase A2 Biochemistry , 2009, Cardiovascular Drugs and Therapy.

[42]  Randal J. Kaufman,et al.  From endoplasmic-reticulum stress to the inflammatory response , 2008, Nature.

[43]  P. Dennen,et al.  Long-term outcomes of acute kidney injury. , 2008, Advances in chronic kidney disease.

[44]  Sudhir V. Shah,et al.  Evaluation and initial management of acute kidney injury. , 2008, Clinical journal of the American Society of Nephrology : CJASN.

[45]  R. Bellomo,et al.  Pathophysiology of septic acute kidney injury: What do we really know? , 2008, Critical care medicine.

[46]  A. Bagga,et al.  The contrasting characteristics of acute kidney injury in developed and developing countries , 2008, Nature Clinical Practice Nephrology.

[47]  O. Aslan,et al.  Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. , 2007, American heart journal.

[48]  A. Colombo,et al.  Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): A Randomized Comparison of 3 Preventive Strategies , 2007, Circulation.

[49]  John A Kellum,et al.  Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury , 2007, Critical care.

[50]  D. Peters,et al.  N-Acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON)* , 2007, Critical care medicine.

[51]  Haomiao Jia,et al.  N-Acetylcysteine and Sodium Bicarbonate Versus N-Acetylcysteine and Standard Hydration for the Prevention of Radiocontrast-Induced Nephropathy Following Coronary Angiography , 2007, The Annals of pharmacotherapy.

[52]  Y. Akamatsu,et al.  Continuous low-dose human atrial natriuretic peptide promotes diuresis in oliguric patients after living donor liver transplantation. , 2006, Transplantation proceedings.

[53]  A. Lisbon,et al.  CRITICAL CARE ISSUES FOR THE NEPHROLOGIST: Low‐dose Dopamine in the Intensive Care Unit , 2006 .

[54]  K. Ho,et al.  Meta-analysis of frusemide to prevent or treat acute renal failure , 2006, BMJ : British Medical Journal.

[55]  F. Veglia,et al.  N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. , 2006, The New England journal of medicine.

[56]  M. Hynninen,et al.  N-Acetylcysteine for the Prevention of Kidney Injury in Abdominal Aortic Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial , 2006, Anesthesia and analgesia.

[57]  R. Salomão,et al.  Bacterial recognition and induced cell activation in sepsis. , 2006, Endocrine, metabolic & immune disorders drug targets.

[58]  K. Eckardt,et al.  'Low-dose' dopamine worsens renal perfusion in patients with acute renal failure. , 2006, Kidney international.

[59]  K. Farrington,et al.  Management of acute renal failure , 2006, Postgraduate Medical Journal.

[60]  F. McAlister,et al.  Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence. , 2006, Archives of internal medicine.

[61]  M. Makuuchi,et al.  Prevention of Renal Impairment by Continuous Infusion of Human Atrial Natriuretic Peptide after Liver Transplantation , 2005, Transplantation.

[62]  J. Tumlin,et al.  Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. , 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[63]  S. Bagshaw,et al.  Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. , 2005, Archives of internal medicine.

[64]  Claude D Martin,et al.  Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study. , 2005, Critical care medicine.

[65]  Joseph Beyene,et al.  Meta-Analysis: Low-Dose Dopamine Increases Urine Output but Does Not Prevent Renal Dysfunction or Death , 2005, Annals of Internal Medicine.

[66]  C. Bokemeyer,et al.  Nephroprotection by theophylline in patients with cisplatin chemotherapy: a randomized, single-blinded, placebo-controlled trial. , 2005, Journal of the American Society of Nephrology : JASN.

[67]  C. McCulloch,et al.  Theophylline for the prevention of radiocontrast nephropathy: a meta-analysis. , 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[68]  A. Cunningham,et al.  Fenoldopam Mesylate for the Prevention of Contrast-Induced Nephropathy: A Randomized Controlled Trial , 2004 .

[69]  J. Bonventre,et al.  Ischemic acute renal failure: an inflammatory disease? , 2004, Kidney international.

[70]  R. Schrier,et al.  Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. , 2004, The Journal of clinical investigation.

[71]  S. Ricksten,et al.  Recombinant human atrial natriuretic peptide in ischemic acute renal failure: A randomized placebo-controlled trial* , 2004, Critical care medicine.

[72]  R. Bellomo,et al.  Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group , 2004, Critical care.

[73]  R. Bersin,et al.  Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. , 2004, JAMA.

[74]  A. Medford,et al.  Differential expression of Toll‐like receptor (TLR)‐2 and TLR‐4 on monocytes in human sepsis , 2004, Clinical and experimental immunology.

[75]  K. Walley,et al.  Bad medicine: low-dose dopamine in the ICU. , 2003, Chest.

[76]  G. Chertow,et al.  Diuretics, mortality, and nonrecovery of renal function in acute renal failure , 2003 .

[77]  R. Hotchkiss,et al.  The pathophysiology and treatment of sepsis. , 2003, The New England journal of medicine.

[78]  S. Dzik.  Early goal-directed therapy in the treatment of severe sepsis and septic shock , 2002 .

[79]  D. Basile,et al.  Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. , 2001, American journal of physiology. Renal physiology.

[80]  M. D. de Broe,et al.  Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury. , 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[81]  J. Lewis,et al.  Atrial natriuretic factor in oliguric acute renal failure , 2000 .

[82]  W Zidek,et al.  Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. , 2000, The New England journal of medicine.

[83]  Y. Kohjimoto,et al.  Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. , 1999, Kidney international.

[84]  F. Gusovsky,et al.  Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction* , 1999, The Journal of Biological Chemistry.

[85]  A. Gurney,et al.  Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling , 1998, Nature.

[86]  R. Nemenoff,et al.  Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice. , 1998, Kidney international.

[87]  R. Lafayette,et al.  Anaritide in Acute Tubular Necrosis , 1997 .

[88]  G. Chertow,et al.  "Renal-dose" dopamine for the treatment of acute renal failure: scientific rationale, experimental studies and clinical trials. , 1996, Kidney international.

[89]  M. Goligorsky,et al.  In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. , 1996, The Journal of clinical investigation.

[90]  M. Yaqoob,et al.  Arachidonic acid protects against hypoxic injury in rat proximal tubules. , 1996, Kidney international.

[91]  M. Brezis,et al.  Determinants of intrarenal oxygenation. I. Effects of diuretics. , 1994, The American journal of physiology.

[92]  J. D'Elia,et al.  Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents. , 1994, The New England journal of medicine.

[93]  R. Schrier,et al.  Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injury. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[94]  R. Zager,et al.  Phospholipase A2 activity can protect renal tubules from oxygen deprivation injury. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[95]  K. Badr,et al.  Prerenal failure: a deleterious shift from renal compensation to decompensation. , 1988, The New England journal of medicine.

[96]  T. Simmen,et al.  Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). , 2013, Biochimica et biophysica acta.

[97]  P. Devarajan.  Neutrophil gelatinase-associated lipocalin : a troponin-like biomarker for human acute kidney injury , 2011 .

[98]  S. Bagshaw,et al.  Fluid overload as a biomarker of heart failure and acute kidney injury. , 2010, Contributions to nephrology.

[99]  S. Nigwekar,et al.  N-acetylcysteine in cardiovascular-surgery-associated renal failure: a meta-analysis. , 2009, The Annals of thoracic surgery.

[100]  A. Elster.  Sodium Bicarbonate Versus Saline for the Prevention of Contrast-Induced Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention , 2009 .

[101]  Jonathan Himmelfarb,et al.  Acute kidney injury increases risk of ESRD among elderly. , 2009, Journal of the American Society of Nephrology : JASN.

[102]  J. Sellgren,et al.  Differential effects of human atrial natriuretic peptide and furosemide on glomerular filtration rate and renal oxygen consumption in humans , 2004, Intensive Care Medicine.

[103]  G. Chertow,et al.  Atrial natriuretic factor in oliguric acute renal failure. Anaritide Acute Renal Failure Study Group. , 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[104]  R. Lafayette,et al.  Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group. , 1997, The New England journal of medicine.

[105]  G. Moneta.  Impact of a High Loading Dose of Atorvastatin on Contrast-Induced Acute Kidney Injury , 2022 .