Comparação entre oxibutinina, eletroestimulação do nervo tibial posterior e exercícios perineais no tratamento da síndrome da bexiga hiperativa

RESUMO Objetivou-se avaliar a eficácia dos exercícios perineais, da eletroestimulação transcutânea do nervo tibial posterior (ETNTP) e da oxibutinina em mulheres com síndrome da bexiga hiperativa, que é a segunda causa mais comum de incontinência urinária, com sintomas urinários extremamente incômodos que prejudicam a qualidade de vida. Foram randomizadas 65 mulheres, das quais 57 completaram o tratamento. Formaram-se três grupos: o de exercícios perineais, ETNTP e o grupo controle, que utilizou oxibutinina. Os exercícios foram realizados em grupo, nas posições em pé, supino e sentado, duas vezes por semana, com duração de 30 minutos cada sessão, totalizando 12 sessões. Na ETNTP utilizou-se eletrodo transcutâneo posicionado em maléolo medial e outro 10cm acima, com frequência de 10Hz e largura de pulso de 200 microssegundos, por 30 minutos, duas vezes por semana, totalizando 12 sessões. Na medicação as pacientes receberam oxibutinina de 10mg/dia de liberação imediata divididos e duas doses de 5mg/dia, durante 12 semanas consecutivas. Antes e depois dos tratamentos, as pacientes passaram por uma avaliação composta pela análise do diário miccional, avaliação funcional do assoalho pélvico e aplicação de questionário de qualidade de vida OAB-V8. Houve redução da incontinência de urgência em 50%, 70,5% e 41% nos grupos de exercício, ETNTP e oxibutinina, respectivamente, com significância estatística somente da eletroestimulação. As três modalidades de tratamento foram eficazes na melhora da qualidade de vida para a terapêutica em curto prazo, estatisticamente semelhantes entre si.

[1]  Viviane Herrmann,et al.  Eletroterapia como primeira linha no tratamento da bexiga hiperativa (BH) , 2018 .

[2]  P. Anderson,et al.  Nocturia is more bothersome than daytime LUTS: Results from an Observational, Real‐life Practice Database including 8659 European and American LUTS patients , 2018, International journal of clinical practice.

[3]  R. Castro,et al.  Pelvic floor muscle training for overactive bladder symptoms - A prospective study. , 2017, Revista da Associacao Medica Brasileira.

[4]  Hein Putter,et al.  The effect of EMG biofeedback assisted pelvic floor muscle therapy on symptoms of the overactive bladder syndrome in women: A randomized controlled trial , 2017, Neurourology and urodynamics.

[5]  T. Ziv-Baran,et al.  Outcomes of different protocols of pelvic floor physical therapy and anti‐cholinergics in women with wet over‐active bladder: A 4‐year follow‐up , 2017, Neurourology and urodynamics.

[6]  M. Baroni,et al.  Percutaneous tibial nerve stimulation versus electrical stimulation with pelvic floor muscle training for overactive bladder syndrome in women: results of a randomized controlled study , 2017, International braz j urol : official journal of the Brazilian Society of Urology.

[7]  L. Cardozo,et al.  Current and future pharmacotherapy for treating overactive bladder , 2016, Expert opinion on pharmacotherapy.

[8]  R. Dmochowski,et al.  The Burden of Overactive Bladder on US Public Health , 2016, Current Bladder Dysfunction Reports.

[9]  Ariel Castro,et al.  Transcutaneous posterior tibial nerve stimulation versus extended release oxybutynin in overactive bladder patients. A prospective randomized trial. , 2016, European journal of obstetrics, gynecology, and reproductive biology.

[10]  E. J. D. Costa e Silva,et al.  Transcutaneous electrical neural stimulation for the treatment of urinary urgency or urge-incontinence in children and adolescents: a Phase II clinica. , 2015, Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.

[11]  H. Rahardjo,et al.  Effectiveness of Short Term Percutaneous Tibial Nerve Stimulation for Non-neurogenic Overactive Bladder Syndrome in Adults: A Meta-analysis. , 2015, Acta medica Indonesiana.

[12]  Silvia Regina Barrile,et al.  Prevalência de sintomas da síndrome de bexiga hiperativa em estudantes do curso de fisioterapia de uma faculdade de Bauru , 2015 .

[13]  Mayra Aparecida Côrtes,et al.  PROPOSTA DE TRATAMENTO FISIOTERAPÊUTICO PARA MELHORIA DA INCONTINÊNCIA URINÁRIA DE ESFORÇO PÓS- TRAUMA: RELATO DE CASO PROPOSAL PHYSIOTHERAPEUTIC TREATMENT FOR IMPROVEMENT OF URINARY INCONTINENCE POST TRAUMA: CASE REPORT , 2015 .

[14]  P. Bigot,et al.  Transcutaneous posterior tibial nerve stimulation: evaluation of a therapeutic option in the management of anticholinergic refractory overactive bladder , 2014, International Urogynecology Journal.

[15]  L. Reis,et al.  Prospective and randomized comparison of electrical stimulation of the posterior tibial nerve versus oxybutynin versus their combination for treatment of women with overactive bladder syndrome , 2014, World Journal of Urology.

[16]  S. Radomski,et al.  Pharmacotherapy of overactive bladder in adults: a review of efficacy, tolerability, and quality of life , 2013, Research and reports in urology.

[17]  Yuan-Hong Jiang,et al.  Increased Serum Adipokines Implicate Chronic Inflammation in the Pathogenesis of Overactive Bladder Syndrome Refractory to Antimuscarinic Therapy , 2013, PloS one.

[18]  K. Burgio Update on Behavioral and Physical Therapies for Incontinence and Overactive Bladder: The Role of Pelvic Floor Muscle Training , 2013, Current Urology Reports.

[19]  Christopher J. Miller,et al.  Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder: 3-year results of the STEP study. , 2013, The Journal of urology.

[20]  B. Berghmans,et al.  Effects of percutaneous tibial nerve stimulation on adult patients with overactive bladder syndrome: A systematic review , 2013, Neurourology and urodynamics.

[21]  Waldemar Naves do Amaral,et al.  Fisioterapia no tratamento da urgência miccional feminina , 2013 .

[22]  G. Vijaya,et al.  Changes in nerve growth factor level and symptom severity following antibiotic treatment for refractory overactive bladder , 2013, International Urogynecology Journal.

[23]  K. Burgio,et al.  Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline. , 2012, The Journal of urology.

[24]  M. Damodaram,et al.  Neuromodulative treatment with percutaneous tibial nerve stimulation for intractable detrusor instability: outcomes following a shortened 6‐week protocol , 2010, BJU international.

[25]  P. Pasqualetti,et al.  Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial. , 2010, The Journal of urology.

[26]  M. R. Knorst,et al.  Randomized trial of transcutaneous tibial nerve stimulation to treat urge urinary incontinence in older women , 2010, International Urogynecology Journal.

[27]  S. Ubee,et al.  Medical management of overactive bladder , 2010, Indian journal of urology : IJU : journal of the Urological Society of India.

[28]  E. F. Manffra,et al.  Qualidade de vida de mulheres com bexiga hiperativa refratária tratadas com estimulação elétrica do nervo tibial posterior , 2009 .

[29]  S. Shobeiri,et al.  Randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the overactive bladder innovative therapy trial. , 2009, The Journal of urology.

[30]  D. Elser,et al.  Pelvic floor muscle function in women presenting with pelvic floor disorders , 2009, International Urogynecology Journal.

[31]  R. Freeman,et al.  An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction , 2010, International Urogynecology Journal.

[32]  P. Perimenis,et al.  Pharmacotherapy of urinary incontinence , 2009, International Urogynecology Journal.

[33]  S. Macdiarmid,et al.  The effects of reformulation: Improved therapeutic index , 2008, Current Urology Reports.

[34]  Z. Gabriel,et al.  The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis. , 2008, European urology.

[35]  V. H. Rodrigues,et al.  Estimulação do nervo tibial posterior no tratamento da bexiga hiperativa , 2008 .

[36]  E. Baracat,et al.  Prospective randomized comparison of oxybutynin, functional electrostimulation, and pelvic floor training for treatment of detrusor overactivity in women , 2008, International Urogynecology Journal.

[37]  R. Dmochowski,et al.  Urgency assessment in the evaluation of overactive bladder (OAB) , 2008, Neurourology and urodynamics.

[38]  M. Lechleitner,et al.  Evaluation of pelvic floor muscle function in a random group of adult women in Austria , 2007, International Urogynecology Journal.

[39]  R. Castro,et al.  Impact of supervised physiotherapeutic pelvic floor exercises for treating female stress urinary incontinence. , 2007, Sao Paulo medical journal = Revista paulista de medicina.

[40]  S. Ross,et al.  Randomized trial of oxybutynin extended versus immediate release for women aged 65 and older with overactive bladder: lessons learned from conducting a trial. , 2007, Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC.

[41]  M. Moen,et al.  Knowledge and Performance of Pelvic Muscle Exercises in Women , 2007 .

[42]  Min-Chi Chen,et al.  Comparison of electric stimulation and oxybutynin chloride in management of overactive bladder with special reference to urinary urgency: a randomized placebo-controlled trial. , 2006, Urology.

[43]  T. Graziottin,et al.  Overactive bladder: prevalence and implications in Brazil. , 2006, European urology.

[44]  C. Acquadro,et al.  Translating overactive bladder questionnaires in 14 languages. , 2006, Urology.

[45]  M. J. B. C. Girão,et al.  Diagnóstico clínico e subsidiário da incontinência urinária , 2006 .

[46]  C. Germiyanoğlu,et al.  Stoller afferent nerve stimulation in woman with therapy resistant over active bladder; a 1-year follow up , 2006, International Urogynecology Journal.

[47]  M. J. B. C. Girão,et al.  Validação do questionário de qualidade de vida (King's Health Questionnaire) em mulheres brasileiras com incontinência urinária , 2005 .

[48]  T. Şenkul,et al.  A peripheric neuromodulation technique for curing detrusor overactivity: Stoller afferent neurostimulation , 2005, Scandinavian journal of urology and nephrology.

[49]  J. Ouslander,et al.  Management of Overactive Bladder , 2004, CNS Spectrums.

[50]  A. L. López,et al.  Peripheral afferent nerve stimulation for treatment of lower urinary tract irritative symptoms. , 2004 .

[51]  Alex C. Wang,et al.  Single-blind, randomized trial of pelvic floor muscle training, biofeedback-assisted pelvic floor muscle training, and electrical stimulation in the management of overactive bladder. , 2004, Urology.

[52]  B. Parratte,et al.  Urodynamic effect of acute transcutaneous posterior tibial nerve stimulation in overactive bladder. , 2003, The Journal of urology.

[53]  A. Shafik,et al.  Overactive bladder inhibition in response to pelvic floor muscle exercises , 2003, World Journal of Urology.

[54]  L. Kiemeney,et al.  Posterior tibial nerve stimulation in the treatment of idiopathic nonobstructive voiding dysfunction. , 2003, Urology.

[55]  M. Fall,et al.  The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. , 2002 .

[56]  Rodolfo Borges dos Reis,et al.  Incontinência urinária no idoso , 2003 .

[57]  D. Roth,et al.  Urodynamic Changes Associated with Behavioral and Drug Treatment of Urge Incontinence in Older Women , 2002, Journal of the American Geriatrics Society.

[58]  L. Kiemeney,et al.  Posterior tibial nerve stimulation as neuromodulative treatment of lower urinary tract dysfunction. , 2001, The Journal of urology.

[59]  K. Kreder,et al.  Percutaneous afferent neuromodulation for the refractory overactive bladder: results of a multicenter study. , 2001, The Journal of urology.

[60]  J. Malone-lee,et al.  Overactive bladder: special considerations in the geriatric population. , 2000, The American journal of managed care.

[61]  I. Nygaard,et al.  Reproducibility of the Seven-Day Voiding Diary in Women with Stress Urinary Incontinence , 2000, International Urogynecology Journal.