This comprehensive text explores all facets of positron emission tomography (PET). It will serve as an excellent textbook for PET fellowships or for nuclear medicine residents. This text will also serve as a definitive reference for PET researchers and practitioners. The field of PET imaging requires the collaboration of experts from various disciplines. Such experts include physicists, radiochemists, mathematicians, technologists, and nuclear medicine physicians and radiologists. This book successfully enlists the collaboration of these experts in the PET field. The book is divided into 10 parts, which cover basic science and current and future clinical science applications, with the majority of the text dedicated to the latter. Experts who are internationally respected in their field wrote each chapter. The overall organization of the text allows the book to be read in a consecutive or a chapter-selective fashion. The individual chapters are both comprehensive and succinct, with adequate references for further reading. The book has many figures and images, which are well integrated into the text and illustrate the concepts described. When appropriate, color images and figures are provided. A chapter on the history of PET instrumentation, tracer development, and kinetic modeling helps the reader understand both the potential of and the current limitations on clinical PET applications. The basic science section covers instrumentation, radiochemistry, dosimetry, reconstruction, registration, and kinetic modeling. Topics that are discussed in the clinical applications section include the central nervous system, cardiorespiratory systems, oncology, infectious disease, pediatrics, drug development, and the monitoring of gene therapy. Also included are chapters detailing the technologist’s perspective and technology design and evaluation. A unique aspect of this book is that it focuses on the future of PET. Fluorine 18 fluorodeoxyglucose is currently the most widely used PET tracer, but with the development of new PET tracers that provide functional imaging of hypoxia, proliferation, neuroreceptor binding, and gene therapy, the full potential of PET imaging is just on the horizon. Current and future clinical applications of such PET agents are discussed in this text. This multidisciplinary, comprehensive text will serve as an essential reference in the rapidly developing PET field. While other books on PET are available, none has the breadth and depth of information contained in this readable, authoritative text.