Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

[1]  W. Cavenee,et al.  Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  C. Berking,et al.  Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. , 2000, Cancer research.

[3]  J. Epstein,et al.  Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. , 2000, The Journal of clinical investigation.

[4]  M. Rudnicki,et al.  Pax7 Is Required for the Specification of Myogenic Satellite Cells , 2000, Cell.

[5]  M. Herlyn,et al.  An Engineered PAX3-KRAB Transcriptional Repressor Inhibits the Malignant Phenotype of Alveolar Rhabdomyosarcoma Cells Harboring the Endogenous PAX3-FKHR Oncogene , 2000, Molecular and Cellular Biology.

[6]  B. Schäfer,et al.  Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR , 2000, Oncogene.

[7]  R. Medema,et al.  AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.

[8]  J. Berzofsky,et al.  Targeting Tumor Specific Translocations in Sarcomas in Pediatric Patients for Immunotherapy , 2000, Clinical orthopaedics and related research.

[9]  Yun Cao,et al.  The COOH-terminal Transactivation Domain Plays a Key Role in Regulating the in Vitro and in Vivo Function of Pax3 Homeodomain* , 2000, The Journal of Biological Chemistry.

[10]  F. Barr,et al.  Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. , 2000, Cancer genetics and cytogenetics.

[11]  L. Peso,et al.  Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt , 1999, Oncogene.

[12]  R. Davis,et al.  Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines. , 1999, Cancer research.

[13]  Y. Nishizuka,et al.  Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  T. Dexter,et al.  Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter* , 1999, The Journal of Biological Chemistry.

[15]  B. Schäfer,et al.  PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma , 1999, Oncogene.

[16]  G. Grosveld,et al.  The Pax3–FKHR oncoprotein is unresponsive to the Pax3‐associated repressor hDaxx , 1999, The EMBO journal.

[17]  P. Cohen,et al.  Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence* , 1999, The Journal of Biological Chemistry.

[18]  K. Guan,et al.  Negative Regulation of the Forkhead Transcription Factor FKHR by Akt* , 1999, The Journal of Biological Chemistry.

[19]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[20]  M. Roussel,et al.  The Oncogenic Potential of the Pax3-FKHR Fusion Protein Requires the Pax3 Homeodomain Recognition Helix but Not the Pax3 Paired-Box DNA Binding Domain , 1999, Molecular and Cellular Biology.

[21]  P. Scambler,et al.  HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3 , 1998, Nature Genetics.

[22]  M. Loeken,et al.  Identification of a New Binding Motif for the Paired Domain of Pax-3 and Unusual Characteristics of Spacing of Bipartite Recognition Elements on Binding and Transcription Activation* , 1998, The Journal of Biological Chemistry.

[23]  J. Epstein,et al.  Tumor-Specific PAX3-FKHR Transcription Factor, but Not PAX3, Activates the Platelet-Derived Growth Factor Alpha Receptor , 1998, Molecular and Cellular Biology.

[24]  T. Braun,et al.  Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb , 1998, Mechanisms of Development.

[25]  F. Barr,et al.  Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma. , 1998, Cancer genetics and cytogenetics.

[26]  Angelo Rosolen,et al.  Normal and rearranged PAX3 expression in human rhabdomyosarcoma. , 1998, Cancer genetics and cytogenetics.

[27]  K. Takeda,et al.  Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3 , 1998, Nature Genetics.

[28]  P. Hamel,et al.  Interaction of the pRB-family proteins with factors containing paired-like homeodomains , 1998, Oncogene.

[29]  W. Cavenee,et al.  Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. , 1998, Genomics.

[30]  F. Barr,et al.  Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[31]  A. Copp,et al.  Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch) , 1997, Mechanisms of Development.

[32]  C. Kenyon,et al.  daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. , 1997, Science.

[33]  R. Berger,et al.  AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. , 1997, Blood.

[34]  G. Ruvkun,et al.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans , 1997, Nature.

[35]  B. Dworniczak,et al.  The genomic organization and the full coding region of the human PAX7 gene. , 1997, Genomics.

[36]  P. Gros,et al.  Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain. , 1997, Human molecular genetics.

[37]  R. Balling,et al.  Pax genes and organogenesis , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[38]  P. Gros,et al.  The Paired-domain Regulates DNA Binding by the Homeodomain within the Intact Pax-3 Protein* , 1997, The Journal of Biological Chemistry.

[39]  P. Sorensen,et al.  Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  G. Cossu,et al.  Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD , 1997, Cell.

[41]  S. Koester,et al.  Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue , 1997, Cell.

[42]  Arndt Borkhardt,et al.  Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23) , 1997, Oncogene.

[43]  K. Vogan,et al.  An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity , 1996, Molecular and cellular biology.

[44]  B. Schäfer,et al.  Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  P. Vogt,et al.  The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[46]  H. Höfler,et al.  THE DIAGNOSTIC POTENTIAL OF THE CHROMOSOME TRANSLOCATION t(2;13) IN RHABDOMYOSARCOMA: A PCR STUDY OF FRESH‐FROZEN AND PARAFFIN‐EMBEDDED TUMOUR SAMPLES , 1996, The Journal of pathology.

[47]  W. Cavenee,et al.  Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase‐polymerase chain reaction , 1996, Genes, Chromosomes and Cancer.

[48]  W. Knöchel,et al.  Five years on the wings of fork head , 1996, Mechanisms of Development.

[49]  J. Toretsky,et al.  Involvement of IGF-II in human cancer. , 1996, The Journal of endocrinology.

[50]  F. Barr,et al.  Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Epstein,et al.  Pax3 modulates expression of the c-Met receptor during limb muscle development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Biegel,et al.  Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. , 1995, Human molecular genetics.

[53]  W. Gerald,et al.  Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A specific diagnostic assay. , 1995, The American journal of pathology.

[54]  G. Chalepakis,et al.  Identification of DNA recognition sequences for the Pax3 paired domain. , 1995, Gene.

[55]  G. Edelman,et al.  Silencer Elements Modulate the Expression of the Gene for the Neuron-Glia Cell Adhesion Molecule, Ng-CAM (*) , 1995, The Journal of Biological Chemistry.

[56]  Carmen Birchmeier,et al.  Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud , 1995, Nature.

[57]  J. Epstein,et al.  Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells (*) , 1995, The Journal of Biological Chemistry.

[58]  K. Vogan,et al.  Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[59]  H. Riethman,et al.  Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcoma. , 1995, Genomics.

[60]  F. Barr,et al.  The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3 , 1995, Molecular and cellular biology.

[61]  G. Edelman,et al.  Pax-3 contains domains for transcription activation and transcription inhibition. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[62]  B. Schäfer,et al.  Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes. , 1994, Nucleic acids research.

[63]  J. Biegel,et al.  Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. , 1994, Cancer research.

[64]  M. Goulding,et al.  Molecular basis of splotch and Waardenburg Pax-3 mutations. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[65]  T. Furuta An extension of the Heinz-Kato theorem , 1994 .

[66]  J. Downing,et al.  Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. , 1993, Cancer research.

[67]  B. Emanuel,et al.  Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma , 1993, Nature Genetics.

[68]  G. Schaffner,et al.  DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. , 1993, Genes & development.

[69]  J. Biegel,et al.  Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma , 1993, Nature Genetics.

[70]  C. Baldwin,et al.  An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome , 1992, Nature.

[71]  R. Balling,et al.  Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene , 1992, Nature.

[72]  P. Gros,et al.  splotch (Sp2H ), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3 , 1991, Cell.

[73]  M. Valentine,et al.  Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma , 1991, Genes, chromosomes & cancer.

[74]  J. Biegel,et al.  Chromosomal Translocation t(1;13)(p36;q14) in a Case of Rhabdomyosarcoma , 1991, Genes, chromosomes & cancer.

[75]  M. Goulding,et al.  Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis. , 1991, The EMBO journal.

[76]  C. Desplan,et al.  The paired box encodes a second DNA-binding domain in the paired homeo domain protein. , 1991, Genes & development.

[77]  P. Gruss,et al.  The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system , 1990, Mechanisms of Development.

[78]  M. Noll,et al.  Conservation of the paired domain in metazoans and its structure in three isolated human genes. , 1989, The EMBO journal.

[79]  B. Lampkin,et al.  Chromosomal analysis of sixteen human rhabdomyosarcomas. , 1988, Cancer research.

[80]  C. Turc‐Carel,et al.  Consistent chromosomal translocation in alveolar rhabdomyosarcoma. , 1986, Cancer genetics and cytogenetics.

[81]  J. Biegel,et al.  In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma. , 1996, Human molecular genetics.

[82]  P. Gruss,et al.  Pax: genes for mice and men. , 1994, Pharmacology & therapeutics.

[83]  P. Houghton,et al.  A specific chromosomal abnormality in rhabdomyosarcoma. , 1987, Cytogenetics and cell genetics.