An integrative approach to high-performance biomedical problem solving environments on the Grid

We conduct computer simulation experiments in pre-operative planning of vascular reconstruction with a physician in the experimental loop. We constructed a problem solving environment, which offers an integrative approach for constructing and running complex interactive systems. Grid resources are used for access to medical image repositories, segmentation services, simulation of blood flow, and visualization in virtual environments of the simulated results together with medical data obtained from MRI/CT scanners. This case study in vascular reconstruction planning has been validated via contextual analysis in a number of hospitals, resulting in a set of new requirements gathered for future versions of the system.

[1]  Ian T. Foster,et al.  Globus: a Metacomputing Infrastructure Toolkit , 1997, Int. J. High Perform. Comput. Appl..

[2]  Ian T. Foster,et al.  The Anatomy of the Grid: Enabling Scalable Virtual Organizations , 2001, Int. J. High Perform. Comput. Appl..

[3]  Luis Serra,et al.  Dextrous virtual work , 1996, CACM.

[4]  R. G. Belleman,et al.  Immersive Virtual Reality on commodity hardware , 2001 .

[5]  Peter M. A. Sloot,et al.  3D Pulsatile flow with the Lattice Boltzmann BGK Method , 2002 .

[6]  Dieter Kranzlmüller,et al.  Grid-Enabled Visualization with GVK , 2003, European Across Grids Conference.

[7]  A. M. Artoli,et al.  Mesoscopic Computational Haemodynamics , 2003 .

[8]  Guilbert Jj.  The world health report 2002 - reducing risks, promoting healthy life. , 2003 .

[9]  Steven Tuecke,et al.  The Physiology of the Grid An Open Grid Services Architecture for Distributed Systems Integration , 2002 .

[10]  Peter M. A. Sloot,et al.  Simulated vascular reconstruction in a virtual operating theatre , 2001, CARS.

[11]  Ian T. Foster,et al.  Security for Grid services , 2003, High Performance Distributed Computing, 2003. Proceedings. 12th IEEE International Symposium on.

[12]  Douglas C. Schmidt,et al.  Applying a scalable CORBA event service to large-scale distributed interactive simulations , 1999, Proceedings. Fifth International Workshop on Object-Oriented Real-Time Dependable Systems.

[13]  Marian Bubak,et al.  The Polder Computing Environment: a system for interactive distributed simulation , 2002, Concurr. Comput. Pract. Exp..

[14]  Lucio Grandinetti,et al.  Advanced Infrastructures for Future Healthcare , 2000 .

[15]  Ian T. Foster,et al.  MPICH-G2: A Grid-enabled implementation of the Message Passing Interface , 2002, J. Parallel Distributed Comput..

[16]  Peter M. A. Sloot,et al.  Lattice-Boltzmann hydrodynamics on parallel systems , 1998 .

[17]  Michael M. Resch,et al.  MPI Application Development Using the Analysis Tool MARMOT , 2004, International Conference on Computational Science.

[18]  P M Sloot.  Simulation and visualisation in medical diagnosis: perspectives and computational requirements. , 2000, Studies in health technology and informatics.

[19]  Peter M. A. Sloot,et al.  AG-IVE: An Agent Based Solution to Constructing Interactive Simulation Systems , 2002, International Conference on Computational Science.

[20]  A. Hoekstra,et al.  Simulation of a Systolic Cycle in a Realistic Artery with the Lattice Boltzmann BGK Method , 2003 .

[21]  Peter M. A. Sloot,et al.  Heuristic evaluation and context analysis to aid the development of a simulated vascular reconstruction system , 2004 .

[22]  J. C. Mulder,et al.  The personal space station: Bringing interaction within reach , 2002 .

[23]  Peter M. A. Sloot,et al.  Virtual Reality and Desktop as a Combined Interaction-Visualisation Medium for a Problem-Solving Environment , 2003, International Conference on Computational Science.

[24]  Javier Jaén Martínez,et al.  Data Management in an International Data Grid Project , 2000, GRID.

[25]  Marian Bubak,et al.  An interactive grid environment for non-invasive vascular reconstruction , 2004 .

[26]  Peter M. A. Sloot,et al.  GEOPROVE: Geometric Probes for Virtual Environments , 1999, HPCN Europe.

[27]  Peter M. A. Sloot,et al.  Scenario Switches and State Updates in an Agent-based Solution to Constructing Interactive Simulation Systems , 2002 .

[28]  A. Hoekstra,et al.  Mesoscopic simulations of systolic flow in the human abdominal aorta. , 2006, Journal of biomechanics.

[29]  Milan Sonka,et al.  Time-Continuous Segmentation of Cardiac Image Sequences Using Active Appearance Motion Models , 2001, IPMI.

[30]  Peter M. A. Sloot,et al.  A multi-modal interface for an interactive simulated vascular reconstruction system , 2002, Proceedings. Fourth IEEE International Conference on Multimodal Interfaces.

[31]  Marian Bubak,et al.  Experimental Grid Access for Dynamic Discovery and Data Transfer in Distributed Interactive Simulation Systems , 2003, International Conference on Computational Science.

[32]  Howard Rheingold,et al.  Virtual Reality , 1991 .

[33]  Bartosz Balis,et al.  An Infrastructure for Grid Application Monitoring , 2002, PVM/MPI.

[34]  Steven Tuecke,et al.  Grid Service Specification , 2002 .

[35]  J. Boon.  The Lattice Boltzmann Equation for Fluid Dynamics and Beyond , 2003 .

[36]  Marian Bubak,et al.  An interactive Grid for non-invasive vascular reconstruction , 2004, IEEE International Symposium on Cluster Computing and the Grid, 2004. CCGrid 2004..

[37]  Marian Bubak,et al.  Grid Services for HLA-Based Distributed Simulation Frameworks , 2003, European Across Grids Conference.

[38]  Peter M. A. Sloot,et al.  Context analysis to support development of virtual reality applications , 2004, Virtual Reality.