Divide and control: split design of multi-input DNA logic gates.

Logic gates made of DNA have received significant attention as biocompatible building blocks for molecular circuits. The majority of DNA logic gates, however, are controlled by the minimum number of inputs: one, two or three. Here we report a strategy to design a multi-input logic gate by splitting a DNA construct.

[1]  Matthew R. Lakin,et al.  Catalytic Molecular Logic Devices by DNAzyme Displacement , 2014, Chembiochem : a European journal of chemical biology.

[2]  Dmitry M. Kolpashchikov,et al.  Molecular logic gates for DNA analysis: detection of rifampin resistance in M. tuberculosis DNA. , 2012, Angewandte Chemie.

[3]  W. Tseng,et al.  Design of two and three input molecular logic gates using non-Watson-Crick base pairing-based molecular beacons. , 2014, The Analyst.

[4]  Matthew R. Lakin,et al.  Signal propagation in multi-layer DNAzyme cascades using structured chimeric substrates. , 2014, Angewandte Chemie.

[5]  Yan Liu,et al.  Three-input majority logic gate and multiple input logic circuit based on DNA strand displacement. , 2013, Nano letters.

[6]  Shaojun Dong,et al.  Four-way junction-driven DNA strand displacement and its application in building majority logic circuit. , 2013, ACS nano.

[7]  Darko Stefanovic,et al.  Deoxyribozyme-based three-input logic gates and construction of a molecular full adder. , 2006, Biochemistry.

[8]  Weihong Tan,et al.  Colorimetric logic gates based on aptamer-crosslinked hydrogels. , 2012, Chemical communications.

[9]  Yulia V Gerasimova,et al.  Folding of 16S rRNA in a signal-producing structure for the detection of bacteria. , 2013, Angewandte Chemie.

[10]  Darko Stefanovic,et al.  A deoxyribozyme-based molecular automaton , 2003, Nature Biotechnology.

[11]  A. Todd,et al.  MNAzyme qPCR: a superior tool for multiplex qPCR. , 2013, Methods in molecular biology.

[12]  Yulia V Gerasimova,et al.  Nucleic acid detection using MNAzymes. , 2010, Chemistry & biology.

[13]  Vladimir Privman,et al.  Enzyme-based logic systems for information processing. , 2009, Chemical Society reviews.

[14]  D. Sen,et al.  A novel mode of regulation of an RNA-cleaving DNAzyme by effectors that bind to both enzyme and substrate. , 2001, Journal of molecular biology.

[15]  Bin Yang,et al.  Intelligent layered nanoflare: "lab-on-a-nanoparticle" for multiple DNA logic gate operations and efficient intracellular delivery. , 2014, Nanoscale.

[16]  Dmitry M. Kolpashchikov,et al.  Binary probes for nucleic acid analysis. , 2010, Chemical reviews.

[17]  Dmitry M Kolpashchikov,et al.  A Binary Deoxyribozyme for Nucleic Acid Analysis , 2007, Chembiochem : a European journal of chemical biology.

[18]  Darko Stefanovic,et al.  Visual displays that directly interface and provide read-outs of molecular states via molecular graphics processing units. , 2014, Angewandte Chemie.

[19]  G. Seelig,et al.  Enzyme-Free Nucleic Acid Logic Circuits , 2022 .

[20]  Paul E. Young,et al.  MNAzymes, a Versatile New Class of Nucleic Acid Enzymes That Can Function as Biosensors and Molecular Switches , 2009, Journal of the American Chemical Society.

[21]  Darko Stefanovic,et al.  Deoxyribozyme-based logic gates. , 2002, Journal of the American Chemical Society.

[22]  D. Stefanovic,et al.  Exercises in Molecular Computing , 2014, Accounts of chemical research.

[23]  Wei Fang,et al.  Toehold-mediated DNA logic gates based on host-guest DNA-GNPs. , 2014, Chemical communications.

[24]  Dmitry M Kolpashchikov,et al.  Molecular logic gates connected through DNA four-way junctions. , 2010, Angewandte Chemie.

[25]  C. Fuery,et al.  MNAzyme qPCR with superior multiplexing capacity. , 2013, Clinical chemistry.

[26]  Andrew D. Ellington,et al.  Diagnostic Applications of Nucleic Acid Circuits , 2014, Accounts of chemical research.

[27]  Decheng Yang,et al.  MicroRNA: an Emerging Therapeutic Target and Intervention Tool , 2008, International journal of molecular sciences.

[28]  Lei Wang,et al.  Logic gate system with three outputs and three inputs based on switchable electrocatalysis of glucose by glucose oxidase entrapped in chitosan films. , 2015, Chemistry, an Asian journal.

[29]  Kazuhiro Furukawa,et al.  Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates. , 2014, Organic & biomolecular chemistry.

[30]  A. Saghatelian,et al.  DNA-based photonic logic gates: AND, NAND, and INHIBIT. , 2003, Journal of the American Chemical Society.

[31]  Yulia V Gerasimova,et al.  RNA‐Cleaving Deoxyribozyme Sensor for Nucleic Acid Analysis: The Limit of Detection , 2010, Chembiochem : a European journal of chemical biology.

[32]  Kazuo Tanaka,et al.  DNA logic gates. , 2004, Journal of the American Chemical Society.