Enhanced imaging in the GI tract: spectroscopy and optical coherence tomography.

The American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee provides reviews of new or emerging endoscopic technologies that have the potential to have an impact on the practice of GI endoscopy. Evidence-based methodology is used, using a MEDLINE literature search to identify pertinent preclinical and clinical studies on the topic, and a MAUDE (U.S. Food and Drug Administration Center for Devices and Radiological Health) database search to identify the reported adverse events of a given technology. Both are supplemented by accessing the “related articles” feature of PubMed and by scrutinizing pertinent references cited by the identified studies. Controlled clinical trials are emphasized, but in many cases, data from randomized, controlled trials are lacking. In such cases, large case series, preliminary clinical studies, and expert opinions are used. Technical data are gathered from traditional and Web-based publications, proprietary publications, and informal communications with pertinent vendors. For this review, the MEDLINE database was searched through February 2013 by using the keywords spectroscopy, optical coherence tomography, Raman spectroscopy, gastrointestinal, Barrett’s esophagus, pancreas, bile ducts, and colon. Reports on Emerging Technologies are drafted by 1 or 2 members of the ASGE Technology Committee, reviewed and edited by the committee as a whole, and approved by the Governing Board of the ASGE. These reports are scientific reviews provided solely for educational and informational purposes. Reports on Emerging Technologies are not rules and should not be construed as establishing a legal standard of care or as encouraging, advocating, requiring, or discouraging any particular treatment or payment for such treatment.

[1]  Sarah Cho,et al.  Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field‐of‐view screening method discriminating dysplasia from metaplasia , 2014, Journal of biophotonics.

[2]  Vadim Backman,et al.  Association between rectal optical signatures and colonic neoplasia: potential applications for screening. , 2009, Cancer research.

[3]  Qin Huang,et al.  Three-dimensional endomicroscopy of the human colon using optical coherence tomography. , 2009, Optics express.

[4]  Joseph A Izatt,et al.  Criteria for the diagnosis of dysplasia by endoscopic optical coherence tomography. , 2003, Gastrointestinal endoscopy.

[5]  Xingde Li,et al.  Imaging of subsquamous Barrett's epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study. , 2010, Gastrointestinal endoscopy.

[6]  C Murali Krishna,et al.  Discrimination of normal and malignant mucosal tissues of the colon by Raman spectroscopy. , 2007, Photomedicine and laser surgery.

[7]  P. Arcidiacono,et al.  Intraductal Optical Coherence Tomography for Investigating Main Pancreatic Duct Strictures , 2007, The American Journal of Gastroenterology.

[8]  Detection and identification of Colon Cancer and Rectum Cancer Using Fluorescence and Raman Spectrum , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[9]  Benjamin J Vakoc,et al.  Fourier-domain optical coherence tomography: recent advances toward clinical utility. , 2009, Current opinion in biotechnology.

[10]  B. Dietzek,et al.  Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications. , 2012, Journal of biomedical optics.

[11]  Vadim Backman,et al.  Spectroscopic applications in gastrointestinal endoscopy. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[12]  Irving Itzkan,et al.  Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus , 2010, Nature Medicine.

[13]  J G Fujimoto,et al.  Ultrahigh resolution optical coherence tomography of Barrett’s esophagus: preliminary descriptive clinical study correlating images with histology , 2007, Endoscopy.

[14]  Young L. Kim,et al.  Optical Markers in Duodenal Mucosa Predict the Presence of Pancreatic Cancer , 2007, Clinical Cancer Research.

[15]  O. Moine,et al.  Intraductal optical coherence tomography during endoscopic retrograde cholangiopancreatography for investigation of biliary strictures , 2009, Endoscopy.

[16]  K. Badizadegan,et al.  NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes. , 2002, Cancer research.

[17]  Neil G. Terry,et al.  Angle-resolved low coherence interferometry for detection of dysplasia in Barrett's esophagus. , 2011, Gastroenterology.

[18]  Vadim Backman,et al.  A Fiber Optic Probe Design to Measure Depth- Limited Optical Properties In-vivo with Low- Coherence Enhanced Backscattering (lebs) Spectroscopy References and Links , 2022 .

[19]  Vadim Backman,et al.  Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. , 2012, Cancer research.

[20]  Hugh Barr,et al.  Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia. , 2012, Journal of biomedical optics.

[21]  Xingde Li,et al.  Optical coherence tomography imaging of the pancreas: a needle-based approach. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[22]  G. Gelikonov,et al.  In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa. , 1997, Optics express.

[23]  Qin Huang,et al.  Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos). , 2012, Gastrointestinal endoscopy.

[24]  Amy M. Winkler,et al.  In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model , 2011, Molecular Imaging and Biology.

[25]  Vadim Backman,et al.  Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk. , 2008, Gastroenterology.

[26]  Vadim Backman,et al.  Investigating Population Risk Factors of Pancreatic Cancer by Evaluation of Optical Markers in the Duodenal Mucosa , 2009, Disease markers.

[27]  T Fearn,et al.  Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett’s oesophagus , 2005, Gut.

[28]  Yukihiro Ozaki,et al.  Surface-enhanced Raman scattering: realization of localized surface plasmon resonance using unique substrates and methods , 2009, Analytical and Bioanalytical Chemistry.

[29]  R. D. Ferguson,et al.  Differentiation of pancreatic cysts with optical coherence tomography (OCT) imaging: an ex vivo pilot study , 2011, Biomedical optics express.

[30]  I. Itzkan,et al.  Spectral Imaging With Scattered Light: From Early Cancer Detection to Cell Biology , 2012, IEEE Journal of Selected Topics in Quantum Electronics.

[31]  Photini F S Rice,et al.  Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon. , 2010, Journal of biomedical optics.

[32]  Qin Huang,et al.  Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos). , 2012, Gastrointestinal endoscopy.

[33]  P. Testoni,et al.  Optical coherence tomography for bile and pancreatic duct imaging. , 2009, Gastrointestinal endoscopy clinics of North America.

[34]  Brian C Wilson,et al.  Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps. , 2003, Gastrointestinal endoscopy.

[35]  Hugh Barr,et al.  Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus , 2003, The Journal of pathology.

[36]  G. Gelikonov,et al.  Endoscopic applications of optical coherence tomography. , 1998, Optics express.

[37]  G. Gelikonov,et al.  Optical coherence tomography of the esophagus and proximal stomach in health and disease , 2001, American Journal of Gastroenterology.

[38]  Mari Mino-Kenudson,et al.  Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[39]  Amitabh Chak,et al.  Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: a prospective, double-blinded study. , 2005, Gastrointestinal endoscopy.

[40]  Characterization of dysplastic tissue morphology and biochemistry in Barrett's esophagus using diffuse reflectance and light scattering spectroscopy. , 2003, Gastrointestinal endoscopy clinics of North America.

[41]  Vadim Backman,et al.  Rectal Mucosal Microvascular Blood Supply Increase Is Associated with Colonic Neoplasia , 2009, Clinical Cancer Research.

[42]  J G Fujimoto,et al.  Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation , 2009, Endoscopy.

[43]  Jürgen Popp,et al.  A comparative Raman and CARS imaging study of colon tissue , 2009, Journal of biophotonics.

[44]  M. Sivak,et al.  Image analysis for classification of dysplasia in Barrett’s esophagus using endoscopic optical coherence tomography , 2010, Biomedical optics express.

[45]  Tom Fearn,et al.  Elastic scattering spectroscopy for detection of cancer risk in Barrett's esophagus: experimental and clinical validation of error removal by orthogonal subtraction for increasing accuracy. , 2009, Journal of biomedical optics.

[46]  Brett E Bouma,et al.  Optical coherence tomography of the biliary tree during ERCP. , 2002, Gastrointestinal endoscopy.

[47]  Brett E. Bouma,et al.  Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure , 2012, Nature Medicine.

[48]  M. Manfait,et al.  Identification of Raman spectroscopic markers for the characterization of normal and adenocarcinomatous colonic tissues. , 2009, Critical reviews in oncology/hematology.

[49]  Rui Henrique,et al.  Discriminating adenocarcinoma from normal colonic mucosa through deconvolution of Raman spectra. , 2011, Journal of biomedical optics.

[50]  Stephen G Bown,et al.  Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. , 2006, Gastrointestinal endoscopy.

[51]  Jennifer K. Barton,et al.  Novel focused OCT-LIF endoscope , 2011, Biomedical optics express.

[52]  M Fitzmaurice,et al.  Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy. , 2000, Gastroenterology.