The trends of last decades in factories towards closer linked processes and more complex machines lead to far reaching consequences for the entire value adding chain, in case of machine break downs. In order to over-come these challenges the importance of maintenance increases. The key here is to improve the target-oriented availability of a machine or equipment considering its failure costs and criticality in the value adding chain. Important part of the solution to achieve this objective is the dynamic adaption of maintenance strategies to the current situation in a factory using the current remaining useful lifetime of critical machine components. The paper presents the integrated approach following the maintenance reference model developed for the SUPREME project. The key steps for deterioration modeling and remaining useful lifetime prediction of critical components and the following dynamic maintenance planning are detailed.